Solubility Enhancement Techniques
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Recent papers in Solubility Enhancement Techniques
This paper evaluated the performance of an envelope enhancement (EE) algorithm subjectively by children with auditory processing disorder (APD), and objectively through computational models. Speech intelligibility data was collected from... more
The solubility enhancement process of hydrophobic drugs is crucial in formulation development to achieve the bioavailability and therapeutic action of the drug at the target site. About 40% of the new chemical entities that have been... more
Introduction: Amorphous solid dispersions are considered as one of the most powerful strategies to formulate poorly soluble drugs. They are made up of an active pharmaceutical ingredient (API) dispersed at the molecular level in an... more
Context: Drug solubility is one of the most important physicochemical properties for the development of new pharmaceutical products, which, in our study, is a new synthetic molecule, which has been shown to have a potential... more
Vapor pressure of aqueous methyldiethanolamine (MDEA) mixed with various concentrations of 1-butyl-3-methyl-imidazolium tetrafluoroborate ([bmim][BF4]) and 1-butyl-3-methyl-imidazoliumdicyanamide ([bmim][DCA]) have been measured and... more
Curcumin (CUR) is highly lipophilic drug that shows degradation at alkaline pH which restricts its oral bioavailability. The aim of the present study was to enhance the oral bioavailability of CUR by increasing its solubility and... more
A Liquisolid system is the one of the novel technique to enhance solubility and dissolution rate of poorly water soluble drug such as Itraconazole. In this technique liquisolid system refers to formulation of formed by water insoluble... more
Introduction: As a consequence of the target and drug candidate identification process, drugs with higher hydrophobicity and/or lipophilicity are being selected for further development, leading to solubility and dissolution rate limited... more
A strategy for adaptive control and energetic optimization of aerobic fermentors was implemented, with both air flow and agitation speed as manipulated variables. This strategy is separable in its components: control, optimization,... more
The present study was aimed to improve the water solubility and bioavailability of telmisartan by solid dispersion technique. Telmisartan is 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'- yl)methyl]-[1,1'-biphenyl]-2-carboxylic... more
tThe need for development of better surface active agents for upstream oil and gas industry whichcan survive harsh condition of salinity are in great demand, particularly for the applications related toimproved/enhanced oil recovery, flow... more
Ionic liquids are ideal absorbents for vapour absorption refrigeration systems because of their low volatility, and good solubility with different natural refrigerants such as ammonia, water, carbon dioxide, etc. However, the high... more
In this study, the physical solubility and diffusivity of N2O in aqueous MDEA+[bmim][BF4] solutions were measured over a range of temperatures of 303–333K and [bmim][BF4] concentrations of 0–2.0molL−1 at atmospheric pressure. The total... more
In this study, the physical solubility and diffusivity of N 2O in aqueous MDEA+[bmim][BF 4] solutions were measured over a range of temperatures of 303-333K and [bmim][BF 4] concentrations of 0-2.0molL -1 at atmospheric pressure. The... more
Liquisolid compact technique is a novel concept for delivery of drug through oral route. This approach of delivering drug is mostly suitable for lipophilic drug and poorly or water insoluble drugs. The main objective of present study was... more
New protocol for screening efficient and environmentally friendly solvents was proposed and experimentally verified. The guidance for solvent selection comes from computed solubility via COSMO-RS approach. Furthermore, solute-solvent... more
The microstructure of pharmaceutical semi-crystalline solid dispersions has attracted extensive attention due to its complexity that might result in the diversity in physical stability, dissolution behavior, and pharmaceutical performance... more
PREPARATION AND CHARECTERIZATION OF ZOTEPINE SOLID DISPERSIONS BY CYCLODEXTRIN COMPLEXATION Carmen Popescu1, Prashanth Manda2, Abhishek Juluri2, Leon Zhou1, Michael A. Repka2, S.Narasimha Murthy2. 1Roquette America, Inc, 2211Innovation... more
Context: Pharmacological properties and studies of methods of extraction of mangiferin have been reported, but there are not studies related to the solubility of mangiferin in the solvents used in the pharmaceutical industry. Aims: Study... more
Context: The use of quercetin as a potential active pharmaceutical ingredient is limited by low aqueous solubility leading to low bioavailability. A spray-dried solid dispersion technique is used to increase the solubility and dissolution... more
Sustained release biodegradable solid lipid microparticles: Formulation, evaluation and statistical optimization by response surface methodology For preparing nebivolol loaded solid lipid microparticles (SLMs) by the solvent evaporation... more
In this work, successful efforts have been performed for solubility enhancement of acyclovir. pH-sensitive b-Cyclodextrin-g-poly methacrylic acid (MAA) hydrogel microparticles were developed. b-Cyclodextrin, MAA, N,N-methylene... more
In the present study amount of Cefixime and amount of Metronidazole solubilised using PEG 6 K, PEG 20 K, PVP K 30, Brij 30 and Sodium lauryl sulphate alone and in combinations was investigated. Study results showed that drug amount... more
Sustained release biodegradable solid lipid microparticles: Formulation, evaluation and statistical optimization by response surface methodology For preparing nebivolol loaded solid lipid microparticles (SLMs) by the solvent evaporation... more
Introduction: Direct compression is the process of choice for tablet manufacturing due to its simplicity and lesser steps involved. For direct compression, the material of interest should have compressibility and compactibility. The aim... more
In this study, the solubility of sodium chloride in 16 imidazolium-, pyrrolidinium-, pyridinium-, and ammonium-based ionic liquids at different temperatures was measured. The solubility of sodium chloride was found to increase with... more
The primary aim of this review was to improve the solubility and Bioavailability of BCS Class-II drugs because of their low solubility and dissolution rate. Solubility is one of the imp parameter to achieve desired concentration of drug... more
A comprehensive experimental and theoretical screening was performed for identification of curcumin solubilizers. Experimental data led to formulation of a non-linear QSPR model correlating molecular descriptors with measured... more