Our cross-sectional study seeks to propose how to evaluate indirectly serotonin and von Willebrand factor (vWF) concentrations in unstable angina (UA) patients and examine the degree of their impact on diagnostic parameters. We examined... more
Our cross-sectional study seeks to propose how to evaluate indirectly serotonin and von Willebrand factor (vWF) concentrations in unstable angina (UA) patients and examine the degree of their impact on diagnostic parameters. We examined 102 UA patients in total and divided them on the type of UA (progressive or new-onset). Recorded parameters included clinical, anamnestic, hemodynamic, and electrocardiographic findings. The serum vWF was measured by ELISA method. Ion exchange chromatography combined with fluorescence spectrophotometry was used to measure the content of serum serotonin. A multivariable linear regression model was created for indirect assessment of serotonin (adj.R2= 68.1%, p<0.001) included age (β=-3.819, p<0.001), smoking (β=-2.871, p<0.001), pulse pressure (β=-1.036, p=0.001), ST-depression (β=-0.489, p=0.001), while the model with UA type (β=0.807, p=0.004) and pulse pressure (β=0.519, p=0.001) increases quality of serotonin assessment by 18.6%. For evaluation of vWF (adj.R2 = 65.2%, p<0.001) optimal model included age (r=0.522, p<0.001), sex (r=-0.330, p=0.020), smoking (r=0.296, p=0.040), body mass index (BMI) (r=0.438, p=0.010), UA type (r=-0.397, p=0.020), ST-segment depression (r=0.601, p<0.001), and Sokolow-Lyon index (r=-0.359, p=0.001). In accordance to our findings, age, sex, BMI, smoking history, ST depression, pulse pressure are critical predictors of vWF concentration in UA patients. The UA type is an essential independent predictor of serotonin quantitation.
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Postural Orthostatic Tachycardia Syndrome (POTS) is a complex disorder characterized by an abnormal increase in heart rate upon assuming an upright position. While POTS primarily affects the cardiovascular system, it also exerts... more
Postural Orthostatic Tachycardia Syndrome (POTS) is a complex disorder characterized by an abnormal increase in heart rate upon assuming an upright position. While POTS primarily affects the cardiovascular system, it also exerts significant repercussions on physical limitations and cognitive functioning. This research aims to explore the multifaceted impact of POTS on these aspects. In terms of physical limitations, POTS patients commonly experience exercise intolerance, rendering them unable to engage in physical activities or exercise for extended periods without triggering distressing symptoms, including dizziness, rapid heart rate, fatigue, and lightheadedness. Furthermore, orthostatic intolerance poses a challenge for POTS patients as they frequently encounter symptoms such as lightheadedness, dizziness, and fainting when standing upright. Consequently, tasks that necessitate prolonged standing become arduous, thus impinging on activities of daily living and work-related activities. Additionally, chronic fatigue, a prevalent Journal of Contemporary Healthcare Analytics 112 manifestation among POTS patients, further curtails their physical capabilities, as even simple tasks can be exhaustive, often necessitating frequent rest or periods of inactivity to manage symptoms. In the realm of cognitive impairment, POTS patients frequently report experiencing cognitive symptoms colloquially known as "brain fog." These symptoms encompass difficulties with concentration, memory problems, mental fatigue, and slowed information processing. Such cognitive impairments substantially impact daily functioning, work productivity, and academic performance. POTS patients may encounter challenges in maintaining attention and focus, making it difficult to complete tasks requiring sustained concentration or engage in activities demanding cognitive effort. The chronic nature of POTS, coupled with the associated physical limitations and cognitive impairments, can have a profound impact on the mental health of affected individuals. Psychological distress, including anxiety and depression, frequently manifests due to the challenges posed by POTS. These mental health challenges further contribute to cognitive difficulties, exacerbating impairments in attention, memory, and overall cognitive performance.
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Засновник-Національний медичний університет імені О.О.Богомольця МОЗ України Періодичність виходу 4 рази на рік. Журнал внесено до переліку фахових видань. Галузі наук: медичні, фармацевтичні. (наказ МОН України 09.03.2016 № 241)... more
Засновник-Національний медичний університет імені О.О.Богомольця МОЗ України Періодичність виходу 4 рази на рік. Журнал внесено до переліку фахових видань. Галузі наук: медичні, фармацевтичні. (наказ МОН України 09.03.2016 № 241) Реєстраційне свідоцтво КВ № 17028-5798ПР. Рекомендовано Вченою Радою НМУ імені О.О.Богомольця (протокол № 2 від 30.08.2022 р.) Усі права стосовно опублікованих статей залишено за редакцією. Відповідальність за добір та викладення фактів у статтях несуть автори, а за зміст рекламних матеріалів-рекламодавці. Передрук можливий за згоди редакції та з посиланням на джерело. До друку приймаються наукові матеріали, які відповідають вимогам до публікації в даному виданні Founder-Bogomolets National Medical University Ministry of Health of Ukraine Publication frequency-4 times a year. The Journal is included in the list of professional publications in Medical and pharmaceutical Sciences (order MES Ukraine 09.03.2016 № 241) Registration Certificate КВ № 17028-5798ПР.
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The peculiarity of alteration in platelet indices among other physiological changes on adaptation to high altitude is controversial. This review has revealed insufficient information about how changes in platelet indices can be attributed... more
The peculiarity of alteration in platelet indices among other physiological changes on adaptation to high altitude is controversial. This review has revealed insufficient information about how changes in platelet indices can be attributed as a consequence of high-altitude terrain. Further clinical trials are necessary to understand the potential relation between high altitude and changes in thrombocytes and their activity.