Injuries to the tendon include large part of orthopedic activities in animals. Flexor tendons inj... more Injuries to the tendon include large part of orthopedic activities in animals. Flexor tendons injuries can occur in a number of ways, most of them are trauma. The purpose of this study was to use the skin instead of tendon in cases of tendon gap in dogs via an in-vivo experimental study. Five Iranian adult indigenous mix dogs of both sexes were selected. The superficial digital flexor tendon of the left hind limb was exposed under general anesthesia and 3 cm of middle one third of tendon was cut and removed. Then a piece of the shaved skin of the surgical site of the same animal was cut and was replaced for the tendon gap by locking loop suture pattern. The tendon samples were collected from the site of operation on 21st postoperative day for histomorphological evaluation. Histomorphologic study showed transformation of skin structures to tendon by showing degeneration of hair follicles and sebaceous glands and development of fibrous structure. This study reviled that skin transplan...
Bone Morphogenic Protein (BMP) can cause molecular and cellular impulses and induce rapid bone he... more Bone Morphogenic Protein (BMP) can cause molecular and cellular impulses and induce rapid bone healing process. Therefore, it is good for cases of delayed or non-union fractures as well as filling up of intervertebral gaps by osteogenic activity. The bovine long bone were collected and processed through defating, grinding, decalcification, degreasing, protein extraction, dialyzing, purification and lyophilizatioan. The extracted BMP was kept in the refrigerator. Ten adult horses of both sex were used and divided randomely into 2 equal groups. The right metetarsus was prepared and anesthesia was induced by xylazin, diazepam and ketamin Hcl and maintained with halothane 2%. All horses were handled according to Shiraz University regulation for animal rights. Under general anesthesia a window defect was made through midmetatarsal region by electric osteotom in all horses. The horses of the first group received BMP that was injected at the window site of metatarsal bone. The wound was cl...
Background: Osteoporosis represents a bone mass loss unassociated with other chronic diseases and... more Background: Osteoporosis represents a bone mass loss unassociated with other chronic diseases and is related to estrogen deficiency and aging. Bone status can be described by measuring bone mineral density. Silymarin is a purified extract from milk thistle (Silybum marianun). Estrogenic effects of SIL have been observed in ovariectomized (OVX) rats. To evaluate the effect of Silymarin alone and in combination with calcium on bone formation, reabsorbtion and turnover, ninety virgin female rats (120–150g) aged twelve weeks, were randomized into nine groups of ten rats each. Eight groups were ovariohysterectomized under standard anesthesia and one group left intact as an un-operated-control group. After surgery 3 operated groups received silymarin, calcium and combination of both from day five post-op and 3 operated groups received the same treatment 4 weeks after surgery; two operated groups were considered as sham and control operated groups. Treatment continued for 4 weeks in each g...
The aim of this study was to investigate the ultra-structure of the photoreceptor layer of male r... more The aim of this study was to investigate the ultra-structure of the photoreceptor layer of male rats under the effect of methanol intoxication and protective effect of silymarin against the methanol toxicity. Fifteen adult male rats were divided into three groups: Control group, Experimental group I (received 4g/kg methanol by intraperitoneal injection for five days), Experimental group II (received 4 g/kg methanol by intraperitoneal injection for five days and received 250 mg/kg silymarin orally for three months). At the end of the experiment, the eyes were removed; retina was separated near the optic disc and studied by transmission electron microscope. Results showed that the retina in the experimental group I exhibited loss of outer segments and disorganization in inner segment. Increased extra cellular space, disappearance of outer limiting membrane and pyknotic nuclei were seen in this group. But normal outer segment, organized inner segment and normal outer limiting membrane ...
Injuries to the tendon include large part of orthopedic activities in animals. Flexor tendons inj... more Injuries to the tendon include large part of orthopedic activities in animals. Flexor tendons injuries can occur in a number of ways, most of them are trauma. The purpose of this study was to use the skin instead of tendon in cases of tendon gap in dogs via an in-vivo experimental study. Five Iranian adult indigenous mix dogs of both sexes were selected. The superficial digital flexor tendon of the left hind limb was exposed under general anesthesia and 3 cm of middle one third of tendon was cut and removed. Then a piece of the shaved skin of the surgical site of the same animal was cut and was replaced for the tendon gap by locking loop suture pattern. The tendon samples were collected from the site of operation on 21st postoperative day for histomorphological evaluation. Histomorphologic study showed transformation of skin structures to tendon by showing degeneration of hair follicles and sebaceous glands and development of fibrous structure. This study reviled that skin transplan...
Abstract: Milk thistle is native to the Mediterranean region. The plant's leaves and seeds h... more Abstract: Milk thistle is native to the Mediterranean region. The plant's leaves and seeds have been used continuously since, at least Greco-Roman days for treating many ailments particularly those that affect the liver. Silymarin and silybin used so far mostly as ...
ABSTRACT To assess the effect of magnetic field in experimental tendon injuries, ten clinically h... more ABSTRACT To assess the effect of magnetic field in experimental tendon injuries, ten clinically healthy adult indigenous dogs were divided into two equal groups (control and experimental). The left superficial digital flexor tendon was exposed and three windows of 6 mm thickness, 3 mm length, and 2 mm intervals were made under general anesthesia. In the experimental group, the dogs were subjected to a magnetic field of 6 × 800 G for 30 days. The tendon biopsy was collected from the site of operation on the postoperative day 30. Histomorphological changes indicated low rate of inflammatory cells, high rate of mature fibroblast, and increased normal collagen fibers, and these were better in the experimental group. The biomechanical test revealed that the tendons of the dogs in the experimental group were more resistant than tendons of the dogs in the control group. The result of this study indicated that magnetic field therapy reduced edema and local swelling, enhanced proliferation of fibroblasts, and regulated arrangement of collagen fibers, providing a good noninvasive physical therapy for tendinous injuries.
Injuries to the tendon include large part of orthopedic activities in animals. Flexor tendons inj... more Injuries to the tendon include large part of orthopedic activities in animals. Flexor tendons injuries can occur in a number of ways, most of them are trauma. The purpose of this study was to use the skin instead of tendon in cases of tendon gap in dogs via an in-vivo experimental study. Five Iranian adult indigenous mix dogs of both sexes were selected. The superficial digital flexor tendon of the left hind limb was exposed under general anesthesia and 3 cm of middle one third of tendon was cut and removed. Then a piece of the shaved skin of the surgical site of the same animal was cut and was replaced for the tendon gap by locking loop suture pattern. The tendon samples were collected from the site of operation on 21st postoperative day for histomorphological evaluation. Histomorphologic study showed transformation of skin structures to tendon by showing degeneration of hair follicles and sebaceous glands and development of fibrous structure. This study reviled that skin transplan...
Bone Morphogenic Protein (BMP) can cause molecular and cellular impulses and induce rapid bone he... more Bone Morphogenic Protein (BMP) can cause molecular and cellular impulses and induce rapid bone healing process. Therefore, it is good for cases of delayed or non-union fractures as well as filling up of intervertebral gaps by osteogenic activity. The bovine long bone were collected and processed through defating, grinding, decalcification, degreasing, protein extraction, dialyzing, purification and lyophilizatioan. The extracted BMP was kept in the refrigerator. Ten adult horses of both sex were used and divided randomely into 2 equal groups. The right metetarsus was prepared and anesthesia was induced by xylazin, diazepam and ketamin Hcl and maintained with halothane 2%. All horses were handled according to Shiraz University regulation for animal rights. Under general anesthesia a window defect was made through midmetatarsal region by electric osteotom in all horses. The horses of the first group received BMP that was injected at the window site of metatarsal bone. The wound was cl...
Background: Osteoporosis represents a bone mass loss unassociated with other chronic diseases and... more Background: Osteoporosis represents a bone mass loss unassociated with other chronic diseases and is related to estrogen deficiency and aging. Bone status can be described by measuring bone mineral density. Silymarin is a purified extract from milk thistle (Silybum marianun). Estrogenic effects of SIL have been observed in ovariectomized (OVX) rats. To evaluate the effect of Silymarin alone and in combination with calcium on bone formation, reabsorbtion and turnover, ninety virgin female rats (120–150g) aged twelve weeks, were randomized into nine groups of ten rats each. Eight groups were ovariohysterectomized under standard anesthesia and one group left intact as an un-operated-control group. After surgery 3 operated groups received silymarin, calcium and combination of both from day five post-op and 3 operated groups received the same treatment 4 weeks after surgery; two operated groups were considered as sham and control operated groups. Treatment continued for 4 weeks in each g...
The aim of this study was to investigate the ultra-structure of the photoreceptor layer of male r... more The aim of this study was to investigate the ultra-structure of the photoreceptor layer of male rats under the effect of methanol intoxication and protective effect of silymarin against the methanol toxicity. Fifteen adult male rats were divided into three groups: Control group, Experimental group I (received 4g/kg methanol by intraperitoneal injection for five days), Experimental group II (received 4 g/kg methanol by intraperitoneal injection for five days and received 250 mg/kg silymarin orally for three months). At the end of the experiment, the eyes were removed; retina was separated near the optic disc and studied by transmission electron microscope. Results showed that the retina in the experimental group I exhibited loss of outer segments and disorganization in inner segment. Increased extra cellular space, disappearance of outer limiting membrane and pyknotic nuclei were seen in this group. But normal outer segment, organized inner segment and normal outer limiting membrane ...
Injuries to the tendon include large part of orthopedic activities in animals. Flexor tendons inj... more Injuries to the tendon include large part of orthopedic activities in animals. Flexor tendons injuries can occur in a number of ways, most of them are trauma. The purpose of this study was to use the skin instead of tendon in cases of tendon gap in dogs via an in-vivo experimental study. Five Iranian adult indigenous mix dogs of both sexes were selected. The superficial digital flexor tendon of the left hind limb was exposed under general anesthesia and 3 cm of middle one third of tendon was cut and removed. Then a piece of the shaved skin of the surgical site of the same animal was cut and was replaced for the tendon gap by locking loop suture pattern. The tendon samples were collected from the site of operation on 21st postoperative day for histomorphological evaluation. Histomorphologic study showed transformation of skin structures to tendon by showing degeneration of hair follicles and sebaceous glands and development of fibrous structure. This study reviled that skin transplan...
Abstract: Milk thistle is native to the Mediterranean region. The plant's leaves and seeds h... more Abstract: Milk thistle is native to the Mediterranean region. The plant's leaves and seeds have been used continuously since, at least Greco-Roman days for treating many ailments particularly those that affect the liver. Silymarin and silybin used so far mostly as ...
ABSTRACT To assess the effect of magnetic field in experimental tendon injuries, ten clinically h... more ABSTRACT To assess the effect of magnetic field in experimental tendon injuries, ten clinically healthy adult indigenous dogs were divided into two equal groups (control and experimental). The left superficial digital flexor tendon was exposed and three windows of 6 mm thickness, 3 mm length, and 2 mm intervals were made under general anesthesia. In the experimental group, the dogs were subjected to a magnetic field of 6 × 800 G for 30 days. The tendon biopsy was collected from the site of operation on the postoperative day 30. Histomorphological changes indicated low rate of inflammatory cells, high rate of mature fibroblast, and increased normal collagen fibers, and these were better in the experimental group. The biomechanical test revealed that the tendons of the dogs in the experimental group were more resistant than tendons of the dogs in the control group. The result of this study indicated that magnetic field therapy reduced edema and local swelling, enhanced proliferation of fibroblasts, and regulated arrangement of collagen fibers, providing a good noninvasive physical therapy for tendinous injuries.
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