Drug research and evaluation National centre

... Systems: Pyrazolo[5',4':4,5]- and pyrazolo-[3',4':4,5]pyrano[2,3-b]pyridine Derivatives Fabrizio Melani, Lucia Cecchi*, Vittoria Colotta, Giovanna Palazzino and Guido Filacchioni Dipartimento di Scienze Farmaceutiche, Universita' di Firenze, Via Gino Capponi, 9, 50121 Firenze ...

... 1,2,3,4-Tetrahydropyrazolo[4,3-c][ ljbenzazepin-1 -ones as Potential Antitumor Agents Giovanna Palazzino, Lucia Cecchi*, Vittoria Coletta, Fabrizio Metani, and Cuido Filacchioni Dipartimento di Scienze Farmaceutiche, Universita' di Firenze, Via Gino Capponi, 9, 50121 Firenze ...

The phytochemical study of the stem bark and wood of Abuta grandifolia (Mart.) Sandwith led to the identification of four bisbenzylisoquinoline alkaloids (BBIQs), namely (R,S)-2 N-norberbamunine (1), (R,R)-isochondodendrine (2), (S-S)-O4″-methyl, Nb-nor-O6'-demethyl-(+)-curine (3), and (S-S)-O4″-methyl, O6'-demethyl-(+)-curine (4), together with the aporphine alkaloid R-nornuciferine (5), all obtained by countercurrent distribution separation (CCD) and identified on the basis of their spectroscopic data. Alkaloids 3 and 4 were new. All the isolated compounds were tested for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. 1 was the most active against AChE, whereas 3 and 4 were the most potent against BChE. Interestingly, all tested alkaloids are more potent against BChE than against AChE. This selectivity of cholinesterase (ChE) inhibition could be important in order to speculate on their potential therapeutic relevance.

OBIETTIVO Illustrare i risultati di un’indagine condotta nell’agro pontino (Regione Lazio) sull’interesse, la conoscenza ed il reale uso delle piante officinali/ fitoderivati da parte di Veterinari ed Allevatori. Parole chiave: Medicina Veterinaria non Convenzionale (MVnC), fitoterapici, fitoderivati, piante officinali

Equisetum arvense L. is a herbaceous medicinal plant, commonly known as horsetail, whose extracts have been reported to possess diuretic and haemostatic properties. The aim of this study was to evaluate the use of fingerprint chromatographic methods on commercially available raw materials or preparations of E. arvense L. in order to ascertain their quality and identify possible adulterants using HPLC and HPTLC densitometry. Two chromatographic methods were used to determine the chemical fingerprints of E. arvense and other allied species. The first was based on HPTLC identification followed by densitometric measurement at 350 nm. The second was based on HPLC separation. The ease of sample preparation and the possibility of simultaneous analysis of several samples in a short time make HPTLC a method of choice for the comprehensive quality evaluation of herbal products.