Istituto Superiore di Sanità
Drug research and evaluation National centre
The isolation, (13)C-NMR and CD data of two 7-epimer oxindole alkaloids, 10,11-dimethoxyisomitraphylline (1) and 10,11-dimethoxymitraphylline (2) from Cabucala cryptophlebia are reported.
The Curculigo pilosa total extract, its butanolic fraction (0.5 microg-100 mg/kg) and the most active in vitro compound structurally similar to adrenaline, pilosidine (10 ng-l mg/kg), caused a reversible and dose-dependent increase in... more
... III. Fabrizio Melani, Lucia Cecchi, Giovanna Palazzino and Guido Filacchioni* Dipartimento di Scienze Farmaceutiche, Via Gino Capponi, 9, 50121 Firenze, Italy Received November 5, 1984 The synthesis of... more
... 1984,27, 564. (6) Cecchi, L.; Melani, F ... Ariel Ewenson,f Ralph Laufer,s Michael Chorev,ll Zvi Selinger,t and Chaim Gilon*f Departments of Organic Chemistry, Biological Chemistry, and Pharmaceutical Chemistry, The Hebrew University... more
A series of 1,3-diarylpyrazolo[4,5-c]- and -[5,4-c]quinolin-4-ones were prepared and tested for their ability to displace [3H]flunitrazepam from bovine brain membranes. While the 1,3-diarylpyrazolo[4,5-c]quinoline derivatives showed... more
Some 1-aryl-3-methylpyrazolo[4,5-c]quinolin-4-ones, were prepared and tested for their ability to displace specific [3H]flunitrazepam binding from bovine brain membranes. The 1-meta-aryl derivatives were the compounds that bound with the... more
Herbal species different from the official bearberry, Arctostaphylos uva-ursi, are sold through conventional markets and also through non-controlled Internet websites, putting consumer safety at risk owing to the lack of quality control.... more
Four new polyketides, (R)-4-hydroxyeleutherin, eleuthone, eleutherinol-8-O-β-D-glucoside and isoeleuthoside C (dihydroisoeleutherin-5-O-β-D-gentiobioside) were isolated from the bulbs of Eleutherine bulbosa, to join eleutherin,... more