Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM)
ABSTRAK Umbi porang memiliki kadar glukomanan tinggi, sehingga berpotensi untuk dikembangkan menj... more ABSTRAK Umbi porang memiliki kadar glukomanan tinggi, sehingga berpotensi untuk dikembangkan menjadi produk yang bermanfaat dalam menjaga kolesterol. Namun, selama ini hasil pertanian umbi porang belum diolah dan langsung dijual ke pengepul dengan harga yang sangat murah. Masyarakat juga enggan memanfaatkannya karena kandungan kalsium oksalat yang ada di porang menyebabkan gatal dan iritasi pada kulit. Oleh karena itu, kegiatan pengabdian kepada masyarakat (PkM) ini dilakukan untuk memberikan penyuluhan manfaat porang bagi kesehatan, pelatihan pengolahan umbi porang menjadi pangan fungsional yaitu gummy jelly, jelly drink, dan jelly siap seduh, serta pendampingan digital marketing agar produk yang dihasilkan dapat dipasarkan dengan baik dan luas. Peserta yang mengikuti kegiatan ini adalah sebanyak 22 orang dari PKK Pekon Bumiayu, Kabupaten Pringsewu, Provinsi Lampung. Setelah mengikuti kegiatan, 100% peserta memiliki peningkatan pengetahuan terkait cara pengolahan porang dan pembuat...
Sampo merupakan salah satu sediaan kosmetik yang digunakan untuk keramas sehingga membuat rambut ... more Sampo merupakan salah satu sediaan kosmetik yang digunakan untuk keramas sehingga membuat rambut menjadi bersih dan mudah untuk diatur. Sediaan sampo terdiri dari berbagai komponen, dengan surfaktan merupakan kunci dari pembersihan rambut karena memiliki struktur molekul yang terdiri dari bagian hidrofilik dan lipofilik dengan kemampuan menurunkan tegangan permukaan antara air dan kotoran sehingga tersuspensi dalam fase air. Penelitian ini dilakukan untuk melihat pengaruh variasi sodium lauril sulfat (SLS) terhadap karakteristik sifat fisik sampo cair (organoleptik, pH, viskositas, dan bobot jenis). Sampo dibuat dengan metode emulsifikasi menggunakan minyak serai wangi (Cymbopogon nardus (L.) Rendle) dan ekstrak lidah buaya (Aloe vera) sebagai zat aktif. Pada awal formulasi, HPMC dikembangkan terlebih dahulu kemudian dicampurkan dengan fase air lain (berupa SLS, aloe vera, cocomide DEA, propil paraben, metil paraben, mentol, akuades). Fase air dan fase minyak (minyak serai wangi) di...
We developed a facile preparation method of oil-in-water (O/ W) Pickering emulsion in an emollien... more We developed a facile preparation method of oil-in-water (O/ W) Pickering emulsion in an emollient formulation using basil extract (Ocimum americanum L.) as a solid particle stabilizer by fine-tuning the concentration and mixing steps of common cosmetic formulas, such as humectants (hexylene glycol and glycerol), surfactant (Tween 20), and moisturizer (urea). The hydrophobicity of the main phenolic compounds of basil extract (BE), namely, salvigenin, eupatorin, rosmarinic acid, and lariciresinol, supported high interfacial coverage to prevent coalescence of globules. Meanwhile, the presence of carboxyl and hydroxyl groups of these compounds provides active sites for stabilizing the emulsion using urea through the formation of hydrogen bonds. Addition of humectants directed the in situ synthesis of colloidal particles during emulsification. In addition, the presence of Tween 20 can simultaneously reduce the surface tension of the oil but tends to inhibit the adsorption of solid particles at high concentrations, which otherwise formed colloidal particles in water. The level of urea and Tween 20 determined the stabilization system of the O/W emulsion, whether interfacial solid adsorption (Pickering emulsion, PE) or colloidal network (CN). Variation of the partition coefficient of the phenolic compounds present in basil extract facilitated the formation of a mixed PE and CN system with better stability. The addition of excess urea induced interfacial solid particle detachment, which caused the oil droplet enlargement. The choice of stabilization system determined the control of antioxidant activity, diffusion through lipid membranes, and cellular antiaging effects in UV-B-irradiated fibroblasts. Particle sizes of less than 200 nm were found in both stabilization systems, which is beneficial for maximizing their effects. In conclusion, this study provides a technological platform to realize the demand for natural dermal cosmetic and pharmaceutical products with strong antiaging effects.
We developed a facile preparation method of oil-in-water (O/ W) Pickering emulsion in an emollien... more We developed a facile preparation method of oil-in-water (O/ W) Pickering emulsion in an emollient formulation using basil extract (Ocimum americanum L.) as a solid particle stabilizer by fine-tuning the concentration and mixing steps of common cosmetic formulas, such as humectants (hexylene glycol and glycerol), surfactant (Tween 20), and moisturizer (urea). The hydrophobicity of the main phenolic compounds of basil extract (BE), namely, salvigenin, eupatorin, rosmarinic acid, and lariciresinol, supported high interfacial coverage to prevent coalescence of globules. Meanwhile, the presence of carboxyl and hydroxyl groups of these compounds provides active sites for stabilizing the emulsion using urea through the formation of hydrogen bonds. Addition of humectants directed the in situ synthesis of colloidal particles during emulsification. In addition, the presence of Tween 20 can simultaneously reduce the surface tension of the oil but tends to inhibit the adsorption of solid particles at high concentrations, which otherwise formed colloidal particles in water. The level of urea and Tween 20 determined the stabilization system of the O/W emulsion, whether interfacial solid adsorption (Pickering emulsion, PE) or colloidal network (CN). Variation of the partition coefficient of the phenolic compounds present in basil extract facilitated the formation of a mixed PE and CN system with better stability. The addition of excess urea induced interfacial solid particle detachment, which caused the oil droplet enlargement. The choice of stabilization system determined the control of antioxidant activity, diffusion through lipid membranes, and cellular antiaging effects in UV-B-irradiated fibroblasts. Particle sizes of less than 200 nm were found in both stabilization systems, which is beneficial for maximizing their effects. In conclusion, this study provides a technological platform to realize the demand for natural dermal cosmetic and pharmaceutical products with strong antiaging effects.
Sambung Nyawa leaves ( Gynura procumbens (Lour.) Merr has been widely used as herbal medicine whi... more Sambung Nyawa leaves ( Gynura procumbens (Lour.) Merr has been widely used as herbal medicine which requires a quality improvement of the dry extract for industrial production. Extraction solvent optimization is one key factor which determines the quality. This research aims was to find out the optimal ethanol-water composition as extraction solvent by using Simplex Lattice Design (SLD) method of which the total phenolics, total flavonoids and DPPH radical scavenging activity were used as quality parameters. Dried leaves as raw materials were pulverized and screened at Mesh 60, macerated (1:5) with ethanol-water compositition as 1:0; 0.7:0.3; and 0.5:0.5 v/v, shaked for 24 h, filtered. The procedure was repeated twice. Filtrates were collected of which lactose were added (1:2)w/w and spray dried at 100C for 30 min. Dried extracts yielded were evaluated the quality by using SLD method of which the total phenolics, total flavonoids as well as DPPH radical scavenging activity were used...
Sambung Nyawa leaves ( Gynura procumbens (Lour.) Merr has been widely used as herbal medicine whi... more Sambung Nyawa leaves ( Gynura procumbens (Lour.) Merr has been widely used as herbal medicine which requires a quality improvement of the dry extract for industrial production. Extraction solvent optimization is one key factor which determines the quality. This research aims was to find out the optimal ethanol-water composition as extraction solvent by using Simplex Lattice Design (SLD) method of which the total phenolics, total flavonoids and DPPH radical scavenging activity were used as quality parameters. Dried leaves as raw materials were pulverized and screened at Mesh 60, macerated (1:5) with ethanol-water compositition as 1:0; 0.7:0.3; and 0.5:0.5 v/v, shaked for 24 h, filtered. The procedure was repeated twice. Filtrates were collected of which lactose were added (1:2)w/w and spray dried at 100C for 30 min. Dried extracts yielded were evaluated the quality by using SLD method of which the total phenolics, total flavonoids as well as DPPH radical scavenging activity were used...
Background and Aim An antimicrobial delivery in the form of surface-modified lectin of lipid nano... more Background and Aim An antimicrobial delivery in the form of surface-modified lectin of lipid nanoparticles was proposed to improve cellular accumulation. ArtinM, an active toll-like receptor 2 (TLR2) agonist lectin isolated from cempedak (Arthocarpus integrifolia) seeds, was selected to induce cellular engulfment of nanoparticles within infected host cells. Materials and Methods Lipid nanoparticles were prepared using the emulsification technique before electrostatic adsorption of artinM. The formula comprising of rifampicin, soy phospholipid, and polysorbate 80 was optimized by Box-Behnken design to produce the desired particle size, entrapment efficiency, and drug loading. The optimum formula was characterized for morphology, in vitro release, and cellular transport. Results and Discussion Soy phospholipid showed a profound effect on controlling drug loading and entrapment efficiency. Owing to its surface activity, polysorbate 80 contributed significantly to reduce particle size; ...
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM)
ABSTRAK Umbi porang memiliki kadar glukomanan tinggi, sehingga berpotensi untuk dikembangkan menj... more ABSTRAK Umbi porang memiliki kadar glukomanan tinggi, sehingga berpotensi untuk dikembangkan menjadi produk yang bermanfaat dalam menjaga kolesterol. Namun, selama ini hasil pertanian umbi porang belum diolah dan langsung dijual ke pengepul dengan harga yang sangat murah. Masyarakat juga enggan memanfaatkannya karena kandungan kalsium oksalat yang ada di porang menyebabkan gatal dan iritasi pada kulit. Oleh karena itu, kegiatan pengabdian kepada masyarakat (PkM) ini dilakukan untuk memberikan penyuluhan manfaat porang bagi kesehatan, pelatihan pengolahan umbi porang menjadi pangan fungsional yaitu gummy jelly, jelly drink, dan jelly siap seduh, serta pendampingan digital marketing agar produk yang dihasilkan dapat dipasarkan dengan baik dan luas. Peserta yang mengikuti kegiatan ini adalah sebanyak 22 orang dari PKK Pekon Bumiayu, Kabupaten Pringsewu, Provinsi Lampung. Setelah mengikuti kegiatan, 100% peserta memiliki peningkatan pengetahuan terkait cara pengolahan porang dan pembuat...
Sampo merupakan salah satu sediaan kosmetik yang digunakan untuk keramas sehingga membuat rambut ... more Sampo merupakan salah satu sediaan kosmetik yang digunakan untuk keramas sehingga membuat rambut menjadi bersih dan mudah untuk diatur. Sediaan sampo terdiri dari berbagai komponen, dengan surfaktan merupakan kunci dari pembersihan rambut karena memiliki struktur molekul yang terdiri dari bagian hidrofilik dan lipofilik dengan kemampuan menurunkan tegangan permukaan antara air dan kotoran sehingga tersuspensi dalam fase air. Penelitian ini dilakukan untuk melihat pengaruh variasi sodium lauril sulfat (SLS) terhadap karakteristik sifat fisik sampo cair (organoleptik, pH, viskositas, dan bobot jenis). Sampo dibuat dengan metode emulsifikasi menggunakan minyak serai wangi (Cymbopogon nardus (L.) Rendle) dan ekstrak lidah buaya (Aloe vera) sebagai zat aktif. Pada awal formulasi, HPMC dikembangkan terlebih dahulu kemudian dicampurkan dengan fase air lain (berupa SLS, aloe vera, cocomide DEA, propil paraben, metil paraben, mentol, akuades). Fase air dan fase minyak (minyak serai wangi) di...
We developed a facile preparation method of oil-in-water (O/ W) Pickering emulsion in an emollien... more We developed a facile preparation method of oil-in-water (O/ W) Pickering emulsion in an emollient formulation using basil extract (Ocimum americanum L.) as a solid particle stabilizer by fine-tuning the concentration and mixing steps of common cosmetic formulas, such as humectants (hexylene glycol and glycerol), surfactant (Tween 20), and moisturizer (urea). The hydrophobicity of the main phenolic compounds of basil extract (BE), namely, salvigenin, eupatorin, rosmarinic acid, and lariciresinol, supported high interfacial coverage to prevent coalescence of globules. Meanwhile, the presence of carboxyl and hydroxyl groups of these compounds provides active sites for stabilizing the emulsion using urea through the formation of hydrogen bonds. Addition of humectants directed the in situ synthesis of colloidal particles during emulsification. In addition, the presence of Tween 20 can simultaneously reduce the surface tension of the oil but tends to inhibit the adsorption of solid particles at high concentrations, which otherwise formed colloidal particles in water. The level of urea and Tween 20 determined the stabilization system of the O/W emulsion, whether interfacial solid adsorption (Pickering emulsion, PE) or colloidal network (CN). Variation of the partition coefficient of the phenolic compounds present in basil extract facilitated the formation of a mixed PE and CN system with better stability. The addition of excess urea induced interfacial solid particle detachment, which caused the oil droplet enlargement. The choice of stabilization system determined the control of antioxidant activity, diffusion through lipid membranes, and cellular antiaging effects in UV-B-irradiated fibroblasts. Particle sizes of less than 200 nm were found in both stabilization systems, which is beneficial for maximizing their effects. In conclusion, this study provides a technological platform to realize the demand for natural dermal cosmetic and pharmaceutical products with strong antiaging effects.
We developed a facile preparation method of oil-in-water (O/ W) Pickering emulsion in an emollien... more We developed a facile preparation method of oil-in-water (O/ W) Pickering emulsion in an emollient formulation using basil extract (Ocimum americanum L.) as a solid particle stabilizer by fine-tuning the concentration and mixing steps of common cosmetic formulas, such as humectants (hexylene glycol and glycerol), surfactant (Tween 20), and moisturizer (urea). The hydrophobicity of the main phenolic compounds of basil extract (BE), namely, salvigenin, eupatorin, rosmarinic acid, and lariciresinol, supported high interfacial coverage to prevent coalescence of globules. Meanwhile, the presence of carboxyl and hydroxyl groups of these compounds provides active sites for stabilizing the emulsion using urea through the formation of hydrogen bonds. Addition of humectants directed the in situ synthesis of colloidal particles during emulsification. In addition, the presence of Tween 20 can simultaneously reduce the surface tension of the oil but tends to inhibit the adsorption of solid particles at high concentrations, which otherwise formed colloidal particles in water. The level of urea and Tween 20 determined the stabilization system of the O/W emulsion, whether interfacial solid adsorption (Pickering emulsion, PE) or colloidal network (CN). Variation of the partition coefficient of the phenolic compounds present in basil extract facilitated the formation of a mixed PE and CN system with better stability. The addition of excess urea induced interfacial solid particle detachment, which caused the oil droplet enlargement. The choice of stabilization system determined the control of antioxidant activity, diffusion through lipid membranes, and cellular antiaging effects in UV-B-irradiated fibroblasts. Particle sizes of less than 200 nm were found in both stabilization systems, which is beneficial for maximizing their effects. In conclusion, this study provides a technological platform to realize the demand for natural dermal cosmetic and pharmaceutical products with strong antiaging effects.
Sambung Nyawa leaves ( Gynura procumbens (Lour.) Merr has been widely used as herbal medicine whi... more Sambung Nyawa leaves ( Gynura procumbens (Lour.) Merr has been widely used as herbal medicine which requires a quality improvement of the dry extract for industrial production. Extraction solvent optimization is one key factor which determines the quality. This research aims was to find out the optimal ethanol-water composition as extraction solvent by using Simplex Lattice Design (SLD) method of which the total phenolics, total flavonoids and DPPH radical scavenging activity were used as quality parameters. Dried leaves as raw materials were pulverized and screened at Mesh 60, macerated (1:5) with ethanol-water compositition as 1:0; 0.7:0.3; and 0.5:0.5 v/v, shaked for 24 h, filtered. The procedure was repeated twice. Filtrates were collected of which lactose were added (1:2)w/w and spray dried at 100C for 30 min. Dried extracts yielded were evaluated the quality by using SLD method of which the total phenolics, total flavonoids as well as DPPH radical scavenging activity were used...
Sambung Nyawa leaves ( Gynura procumbens (Lour.) Merr has been widely used as herbal medicine whi... more Sambung Nyawa leaves ( Gynura procumbens (Lour.) Merr has been widely used as herbal medicine which requires a quality improvement of the dry extract for industrial production. Extraction solvent optimization is one key factor which determines the quality. This research aims was to find out the optimal ethanol-water composition as extraction solvent by using Simplex Lattice Design (SLD) method of which the total phenolics, total flavonoids and DPPH radical scavenging activity were used as quality parameters. Dried leaves as raw materials were pulverized and screened at Mesh 60, macerated (1:5) with ethanol-water compositition as 1:0; 0.7:0.3; and 0.5:0.5 v/v, shaked for 24 h, filtered. The procedure was repeated twice. Filtrates were collected of which lactose were added (1:2)w/w and spray dried at 100C for 30 min. Dried extracts yielded were evaluated the quality by using SLD method of which the total phenolics, total flavonoids as well as DPPH radical scavenging activity were used...
Background and Aim An antimicrobial delivery in the form of surface-modified lectin of lipid nano... more Background and Aim An antimicrobial delivery in the form of surface-modified lectin of lipid nanoparticles was proposed to improve cellular accumulation. ArtinM, an active toll-like receptor 2 (TLR2) agonist lectin isolated from cempedak (Arthocarpus integrifolia) seeds, was selected to induce cellular engulfment of nanoparticles within infected host cells. Materials and Methods Lipid nanoparticles were prepared using the emulsification technique before electrostatic adsorption of artinM. The formula comprising of rifampicin, soy phospholipid, and polysorbate 80 was optimized by Box-Behnken design to produce the desired particle size, entrapment efficiency, and drug loading. The optimum formula was characterized for morphology, in vitro release, and cellular transport. Results and Discussion Soy phospholipid showed a profound effect on controlling drug loading and entrapment efficiency. Owing to its surface activity, polysorbate 80 contributed significantly to reduce particle size; ...
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