articles by SOURAVI BARDHAN
Advances in Natural Sciences: Nanoscience and Nanotechnology, IOP, 2020
The persistent dissemination of resistant bacterial strains is a grave contemporary global impedi... more The persistent dissemination of resistant bacterial strains is a grave contemporary global impediment in hospital-acquired infections which needs to be mitigated with immediate effect. In particular, infections from pathogenic multidrug-resistant (MDR) Gram-positive bacteria (like Enterococcus faecalis) which are resistant to conventional antibiotic therapy are attracting immediate global attention. Here we report the synthesis of nanoscale hydroxyapatites (HAPs), which are the well known biomimetic ceramic material having needle shaped morphologies. We have encapsulated vancomycin (VAN) within these nanoparticles and have conjugated the targeting ligand (folic acid) by a facile synthesis process in order to enhance the therapeutic efficacy against MDR E. faecalis. These functionalised HAPs are thoroughly characterised by employing field emission scanning electron microscopy (FESEM), powder x-ray diffraction (PXRD), ultraviolet-visible spectroscopy (UV-Vis) and dynamic light-scattering (DLS) techniques. Our results suggest that these functionalised HAPs could successfully transport vancomycin across the cell wall of MDR E. faecalis through endocytosis. The determination of selective antibacterial activity has been envisaged with the help of extensive in-vitro assays like the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and the generation of reactive oxygen species (ROS). This study vividly establishes that this folic acid conjugated HAPs are promising antibacterial agents against MDR E. faecalis and related pathogenic resistant bacterial strains.
Materials Today: Proceedings, 2020
The large scale amplification of industrial discharge in the modern era is resulting in widesprea... more The large scale amplification of industrial discharge in the modern era is resulting in widespread water pollution, especially from various industrial effluents and wastewater containing heavy metals, posing a severe threat to our environment. In order to combat such problems, this work aims on Multifunctional Fluorescent Nano-Sensor (MFNS) mediated simultaneous detection and removal of hexavalent chromium from real life wastewater which further converts it into an energy harvesting material, namely, ''Waste capacitor". This smart material can detect the presence of the targeted heavy metal (Cr(VI)) in the wastewater and can entrap it by using a facile adsorption process. Thereafter, it will change its microstructure which further enhances its dielectric properties. Morphology, microstructure and optical properties of the synthesized material have been studied thoroughly and a turn-off based fluorescence sensing has been reported herein. Photoinduced electron transfer (PET) based fluorescence quenching is mainly responsible for this sensing mechanism. The selectivity and sensitivity of the material during fluorescence sensing have also been studied by using standard Stern-Volmer method showing that the synthesized material is tremendously selective and sensitive towards the specific target ion. High surface area with slit-like porous structure enhances the adsorption based removal of the contaminant. Nearly 76% of contaminants have been removed by using this smart material. After adsorbing specified target, this MFNS changes its microstructure and results in superior dielectric constant with a minimal tangent loss. Tremendous sensitivity (in nM range), selectivity towards the specific contaminant and adsorption of toxic heavy metal and converting it into a green energy harvesting material (waste capacitor) makes this smart multifunctional material a real waste to wealth converter.
Papers by SOURAVI BARDHAN
Dalton Transactions
Piezocatalytic bismuth ferrite nanoparticles (BFO) were used for the degradation of organic dye (... more Piezocatalytic bismuth ferrite nanoparticles (BFO) were used for the degradation of organic dye (RhB) and pathogenic bacteria (E. coli), then extracted using external magnetic stimulation after the successful operation.
Journal of Materials Chemistry C
Energy demand is increasing exponentially nowadays, which primarily causes the burning of fossil ... more Energy demand is increasing exponentially nowadays, which primarily causes the burning of fossil fuels creating enormous amounts of environmental degradation. To arrest this, the need for clean and green technologies...
Journal of Materials Science: Materials in Electronics
This article reports the fluorometric detection of toxic hexavalent chromium Cr (VI)) in wastewat... more This article reports the fluorometric detection of toxic hexavalent chromium Cr (VI)) in wastewater and Cr (VI) contaminated living cells using in-situ grown carbon quantum dots into the goethite (α-FeOOH) nano-matrix. The synthesized nano-hybrid shows enormous potential in determining the chromium contamination levels in various types of water samples. This selective fluorometric probe is enormously sensitive (LOD 81nM) towards hexavalent chromium, which makes it a dedicated chromium sensor. Moreover, the sensing mechanism has been assessed using Stern-Volmer’s equation and fluorescence lifetime experiments showing the simultaneous occurrence of photoinduced electron transfer and inner filter effect. This chromium sensor has also been employed to assess the contamination level in real-life industrial wastewater. The performance of this probe in real-life wastewater sample is quite commendable. Further, this biocompatible fluorometric probe has been used to demonstrate the in-vitro ...
Nanotechnology for Biomedical Applications
Journal of Materials Science: Materials in Electronics
This article reports size fractionation of a natural clay namely kaolinite for fabricating cost-e... more This article reports size fractionation of a natural clay namely kaolinite for fabricating cost-effective green separator material for energy storage devices. kaolinite is reportedly biocompatible and abundantly available in nature, which makes it cost-effective. Such a low-cost clay is found to be in the nano regime when treated in a ball-milling machine for a prolonged duration (12 h). The enhancement in porosity and surface area have also been observed in the treated nano-clay, which subsequently renders it’s dielectric constant (~ 5000 at 40 Hz frequency) remarkably. Henceforth, it can be argued that crystallinity and aspect ratio (S/V) has a prominent impact on the electrical properties of this natural clay. Cyclic voltammetry and galvanostatic charging–discharging measurements depict high specific capacitance (~ 185 F g−1) in the nano-clay sample without the presence of any redox peak making it a good separator material. The slow electrical discharge rate also approves the storage property of this clay sample quite effectively. Abundance, augmented permittivity with a relatively low tangent loss, high specific capacitance and significant resistivity through the material make this nano-clay material a promising ‘green’ dielectric separator for energy storage applications.
Materials Today: Proceedings
Abstract The large scale amplification of industrial discharge in the modern era is resulting in ... more Abstract The large scale amplification of industrial discharge in the modern era is resulting in widespread water pollution, especially from various industrial effluents and wastewater containing heavy metals, posing a severe threat to our environment. In order to combat such problems, this work aims on Multifunctional Fluorescent Nano-Sensor (MFNS) mediated simultaneous detection and removal of hexavalent chromium from real life wastewater which further converts it into an energy harvesting material, namely, “Waste capacitor”. This smart material can detect the presence of the targeted heavy metal (Cr(VI)) in the wastewater and can entrap it by using a facile adsorption process. Thereafter, it will change its microstructure which further enhances its dielectric properties. Morphology, microstructure and optical properties of the synthesized material have been studied thoroughly and a turn-off based fluorescence sensing has been reported herein. Photoinduced electron transfer (PET) based fluorescence quenching is mainly responsible for this sensing mechanism. The selectivity and sensitivity of the material during fluorescence sensing have also been studied by using standard Stern-Volmer method showing that the synthesized material is tremendously selective and sensitive towards the specific target ion. High surface area with slit-like porous structure enhances the adsorption based removal of the contaminant. Nearly 76% of contaminants have been removed by using this smart material. After adsorbing specified target, this MFNS changes its microstructure and results in superior dielectric constant with a minimal tangent loss. Tremendous sensitivity (in nM range), selectivity towards the specific contaminant and adsorption of toxic heavy metal and converting it into a green energy harvesting material (waste capacitor) makes this smart multifunctional material a real waste to wealth converter.
Journal of Alloys and Compounds
Abstract In this article, nanostructures of boehmite (γ-AlOOH) have been successfully synthesized... more Abstract In this article, nanostructures of boehmite (γ-AlOOH) have been successfully synthesized in a time varied, facile and cost effective hydrothermal route. The samples have been characterized by using X-Ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM) and Fourier Transform Infrared (FTIR) spectroscopy. Our samples exhibit remarkably high photoluminescence emission intensity and dielectric constant (3.71 × 106 for BH12 sample) with a nominal dielectric tangent loss. A detailed growth mechanism including the nucleation and self assembly of our nanomaterial has been discussed. Moreover, we are the first to report here the electrical properties of the boehmite nanoparticles. Present investigation also explores temperature dependent dielectric property and ac conductivity of these samples. The role of crystallinity in the optical and electrical enhancement of our samples has been illustrated with proper analytical details. Not only high emission intensity in the blue and green region of the spectrum makes our sample a strong candidate for bio-imaging and bio-sensing applications, but also high dielectric constant makes them desirable for cost-effective energy storing devices, such as supercapacitors and solar cells.
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Dalton Transactions
Among several forms of water pollutants, common pesticides, herbicides, organic dyes and heavy me... more Among several forms of water pollutants, common pesticides, herbicides, organic dyes and heavy metals present serious and persistent threat to human health due to their severe toxicity. Recently, piezocatalysis based...
Journal of Electronic Materials
Sensors and Actuators B: Chemical
Dalton Transactions
This work reports a C-dot loaded natural microcline based selective and sensitive dual fluorescen... more This work reports a C-dot loaded natural microcline based selective and sensitive dual fluorescent probe for hazardous Fe3+ and Cr6+ detection in water along with its effects in real-life water samples.
ACS Applied Materials & Interfaces
In modern society, massive industrialization escalates environmental degradation that liberates v... more In modern society, massive industrialization escalates environmental degradation that liberates various contaminants in the environment. Hexvalent chromium is a heavy metal that is being discharged from tannery and other industries resulting in various carcinogenic diseases. This study reports a carbon dot (cdot) based fluorometric probe to detect hexavalent chromium in water. This is for the very first time when cdot is tailored over the boehmite nanoparticle’s surface by using an in situ approach. Validation of formation of the nanocomposite has been discussed in detail employing Rietveld refinement based x-ray crystallography method. Vibrational spectroscopy and electron microscopy of the sample authenticates the nucleation process and the growth mechanism. The Stern-Volmer approach and time resolved fluorescence measurements justify the sensitivity of the sensor (~58 nM) and selectivity is analyzed by exposing the material in different ionic environments. Density functional theory (DFT) is applied herein to analyze the origin of fluorescence and sensing mechanism of the probe, which shows photoinduced electron transfer (PET) is responsible for turn-off based sensing of Cr(VI). The molecular docking simulation is carried out to ensure the binding of cdot into the binding pocket of glutathione enzyme, which is responsible for treating ROS (Reactive Oxygen Species) mediated DNA damage due to the elements like hexavalent chromium. Time dependent density functional calculations (TDDFT) show the fluorometric probe is capable of detecting Cr(VI) in living cells making it an early stage chromium mediated carcinogen detector.
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articles by SOURAVI BARDHAN
Papers by SOURAVI BARDHAN