부갑상샘 호르몬

PTH
사용 가능한 구조
PDB	동원체 검색: PDBe RCSB
PDB ID 코드 목록
	1BWX, 1ET1, 1FVY, 1HPH, 1HPY, 1HTH, 1ZWA, 1ZWB, 1ZWD, 1ZWE, 1ZWF, 1ZWG, 2L1X, 3C4M
식별자
다른 이름	PTH, PTH1, parathyroid hormone, Parathyroid hormone, FIH1
외부 ID	OMIM: 168450 MGI: 97799 HomoloGene: 266 GeneCards: PTH
유전자 위치 (인간)
염색체	11번 염색체
끝	13,496,181 bp
유전자 위치 (쥐)
염색체	7번 염색체 (쥐)
끝	112,987,777 bp
RNA 발현 패턴
	최상위 발현
	고환; ; 망막색소상피세포; ; 근육 조직; ; body of stomach; ; fundus; ; 배; ; 나팔관; ; 민무늬근; ; ganglionic eminence; ; 젖샘;
	최상위 발현
	기관; ; 부갑상샘; ; 식도; ; 위둔덕; ; 숨뇌; ; 이자; ; 턱밑샘; ; 상실배; ; 가슴샘; ; gastrula;
	추가 참조 발현 데이터
	추가 참조 발현 데이터
유전자 온톨로지
분자 함수	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; hormone activity; parathyroid hormone receptor binding; type 1 parathyroid hormone receptor binding; protein N-terminus binding; receptor ligand activity; peptide hormone receptor binding; DNA-binding transcription factor activity, RNA polymerase II-specific; 단백질 결합;
세포 성분	intracellular anatomical structure; 세포밖공간; 세포 바깥쪽;
생물학적 과정	positive regulation of signal transduction; positive regulation of cell proliferation in bone marrow; positive regulation of osteoclast proliferation; response to fibroblast growth factor; hormone-mediated apoptotic signaling pathway; cAMP metabolic process; response to ethanol; response to parathyroid hormone; skeletal system development; positive regulation of ossification; response to lead ion; 영양 수준에 반응; G protein-coupled receptor signaling pathway; response to vitamin D; negative regulation of apoptotic process in bone marrow cell; negative regulation of transcription by RNA polymerase II; cellular macromolecule biosynthetic process; cellular calcium ion homeostasis; homeostasis of number of cells within a tissue; response to cadmium ion; Rho protein signal transduction; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; bone resorption; positive regulation of bone mineralization; 유전자 발현의 조절; positive regulation of transcription by RNA polymerase II; cell-cell signaling; activation of phospholipase C activity; negative regulation of chondrocyte differentiation; positive regulation of inositol phosphate biosynthetic process; negative regulation of bone mineralization involved in bone maturation; 신호전달 수용체 활성의 조절; adenylate cyclase-activating G protein-coupled receptor signaling pathway; calcium ion transport; magnesium ion homeostasis; bone mineralization; phosphate ion homeostasis; calcium ion homeostasis; negative regulation of calcium ion transport;
	출처: Amigo / QuickGO
동원체
	5741
	19226
	ENSG00000152266
	ENSMUSG00000059077
	P01270
	Q9Z0L6
	NM_000315; NM_001316352
	NM_020623
	NP_000306; NP_001303281
	NP_065648
	위키데이터
인간 보기/편집	쥐 보기/편집

부갑상샘 호르몬(영어: parathyroid hormone, PTH, parathormone, parathyrin)은 뼈, 장기, 소장에 대한 영향을 통해 혈청 칼슘 농도를 조절하는 부갑상샘에 의해 분비되는 펩타이드 호르몬이다.^[5]

PTH는 시간이 지남에 따라 골조직이 골흡수되고 골형성되는 과정인 뼈 리모델링(Bone remodeling)에 영향을 준다. PTH는 낮은 혈청 칼슘(Ca²⁺) 수준에 반응하여 분비된다.

각주

↑ ^가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000152266 - 앙상블, May 2017
↑ ^가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000059077 - 앙상블, May 2017
↑ “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ Coetzee M, Kruger MC (May 2004). “Osteoprotegerin-receptor activator of nuclear factor-kappaB ligand ratio: a new approach to osteoporosis treatment?”. 《Southern Medical Journal》 97 (5): 506–11. doi:10.1097/00007611-200405000-00018. PMID 15180028. S2CID 45131847.

외부 링크

위키미디어 공용에 부갑상샘 호르몬 관련 미디어 분류가 있습니다.
Parathyroid hormone: analyte monograph - the Association for Clinical Biochemistry and Laboratory Medicine
모든 구조 정보의 개요는 유니프롯의 PDB로 볼 수 있습니다: P01270 (Parathyroid hormone) - PDBe-KB.

[refGRCh38Ensembl-1] 가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000152266 - 앙상블, May 2017

[refGRCm38Ensembl-2] 가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000059077 - 앙상블, May 2017

[3] “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[4] “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[pmid15180028-5] Coetzee M, Kruger MC (May 2004). “Osteoprotegerin-receptor activator of nuclear factor-kappaB ligand ratio: a new approach to osteoporosis treatment?”. 《Southern Medical Journal》 97 (5): 506–11. doi:10.1097/00007611-200405000-00018. PMID 15180028. S2CID 45131847.

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