Books by Burcu Alparslan
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Drafts by Burcu Alparslan
Demirsoy U, Alparslan B, Şen MC, Anık Y, Akansel G, Görür G, Gürel B, Aksu G, Çorapçıoğlu F. More... more Demirsoy U, Alparslan B, Şen MC, Anık Y, Akansel G, Görür G, Gürel B, Aksu G, Çorapçıoğlu F. More than Ophelia syndrome: Multiple paraneoplastic syndromes in pediatric Hodgkin lymphoma. Turk J Pediatr 2019; 61: 139-141. Paraneoplastic syndromes in Hodgkin lymphoma (HL) can be seen with different symptoms and organ findings within a significant time before definite diagnosis of the primary disease. Achalasia, Holmes-Adie pupil, and limbic encephalitis are rarely reported paraneoplastic components in pediatric HL. In this report, we present an 11-year-old girl who had all these three paraneoplastic components synchronously before HL was identified.
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Papers by Burcu Alparslan
Journal of neurosciences in rural practice, Apr 25, 2024
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Turkish Journal of Trauma and Emergency Surgery
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Auris Nasus Larynx, Dec 1, 2021
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Soft Computing
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Uludağ Üniversitesi, 2013
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Neuro-Oncology, Sep 1, 2021
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>BACKGROUND</j... more <jats:title>Abstract</jats:title> <jats:sec> <jats:title>BACKGROUND</jats:title> <jats:p>The aim of the systematic review was to assess recently published studies on diagnostic test accuracy of glioblastoma treatment response monitoring biomarkers in adults, developed through machine learning (ML).</jats:p> </jats:sec> <jats:sec> <jats:title>MATERIAL AND METHODS</jats:title> <jats:p>PRISMA methodology was followed. Articles published 09/2018-01/2021 (since previous reviews) were searched for using MEDLINE, EMBASE, and the Cochrane Register by two reviewers independently. Included study participants were adult patients with high grade glioma who had undergone standard treatment (maximal resection, radiotherapy with concomitant and adjuvant temozolomide) and subsequently underwent follow-up imaging to determine treatment response status (specifically, distinguishing progression/recurrence from progression/recurrence mimics - the target condition). Risk of bias and applicability was assessed with QUADAS 2. A third reviewer arbitrated any discrepancy. Contingency tables were created for hold-out test sets and recall, specificity, precision, F1-score, balanced accuracy calculated. A meta-analysis was performed using a bivariate model for recall, false positive rate and area-under the receiver operator characteristic curve (AUC).</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>Eighteen studies were included with 1335 patients in training sets and 384 in test sets. To determine whether there was progression or a mimic, the reference standard combination of follow-up imaging and histopathology at re-operation was applied in 67% (13/18) of studies. The small numbers of patient included in studies, the high risk of bias and concerns of applicability in the study designs (particularly in relation to the reference standard and patient selection due to confounding), and the low level of evidence, suggest that limited conclusions can be drawn from the data. Ten studies (10/18, 56%) had internal or external hold-out test set data that could be included in a meta-analysis of monitoring biomarker studies. The pooled sensitivity was 0.77 (0.65–0.86). The pooled false positive rate (1-specificity) was 0.35 (0.25–0.47). The summary point estimate for the AUC was 0.77.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSION</jats:title> <jats:p>There is likely good diagnostic performance of machine learning models that use MRI features to distinguish between progression and mimics. The diagnostic performance of ML using implicit features did not appear to be superior to ML using explicit features. There are a range of ML-based solutions poised to become treatment response monitoring biomarkers for glioblastoma. To achieve this, the development and validation of ML models require large, well-annotated datasets where the potential for confounding in the study design has been carefully considered. Therefore, multidisciplinary efforts and multicentre collaborations are necessary.</jats:p> </jats:sec>
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BMJ Case Reports
A man in his 70s was admitted to our hospital with complaints of fatigue, loss of appetite and fe... more A man in his 70s was admitted to our hospital with complaints of fatigue, loss of appetite and fever. His neurological examination was normal. He had a medical history of diabetes mellitus for 25 years. Urine analysis showed many leucocytes. Empirical antibiotic treatment was started for urinary system infection. Three days later, his mental status worsened with confusion and disorientation. MRI of the brain was normal. Two days later, the patient was intubated because of respiratory insufficiency. MRI showed restricted diffusion in bilateral thalamic nuclei. Encephalitis and ischaemia were considered in the differential diagnosis. Cerebrospinal fluid IgM antibody for West Nile virus was positive. Sixteen days later, cranial nerve reflexes were lost. MRI showed restricted diffusion and increased T2 signal intensity in the dorsal medulla and increased T2 signal intensity without diffusion restriction in bilateral substantia nigra and dentate nuclei. He died of cardiac arrest 40 days ...
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Çalışmamızın amacı stent hücre geometrisinin karotis stentlemenin orta dönem sonuçlarına etkisini... more Çalışmamızın amacı stent hücre geometrisinin karotis stentlemenin orta dönem sonuçlarına etkisinin olup olmadığını araştırmaktır. 2010-2012 yılları arasında, ortalama yaşı 66 olan 43 ü kadın, 132 si erkek toplam 155 hasta (175 olguya) KAS yapıldı. Non-randomize, retrospektif çalışmamızda 91 açık, 84 kapalı hücreli stent kullanıldı. Işlem sırasında ve 30 gün sonrasında oluşan komplikasyonlar periprosedural komplikasyonlar olarak kabul edildi. Klinik takip bulguları modifiye Rankin skalası kullanarak gruplanan muayene bulgularıyla belirlendi. Restenoz oranları işlem sonrası 6. aydan başlayarak yapılan çok detektörlü bilgisayarlı tomografi anjiografiyle saptandı. Periprosedural dönemde, geçici iskemik atak (GİA) ve tüm inme oranı açık hücreli grupta %3,3 iken kapalı hücreli grupta %3,6 ve ölüm oranları sırasıyla %3,7 ve %3,1 dir. Klinik takipte hiç inme saptanmadı. Her iki grupta sekiz GİA ve iki intrakraniyal kanama (İKK) tanılı olgu vardı. Kapalı hücreli grupta bir hasta miyokard inf...
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Kocaeli Üniversitesi Sağlık Bilimleri Dergisi, 2022
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Poster: "ECR 2012 / C-2495 / Intraabdominal Active Bleeding: Helical CT , MDCT (64-slice), D... more Poster: "ECR 2012 / C-2495 / Intraabdominal Active Bleeding: Helical CT , MDCT (64-slice), DSA and Homeostatic Embolization Findings" by: "B. ALPARSLAN1, N. YILDIRIM1, B. Hakyemez2, A. Ozer1, G. Savci1; 1Bursa/TR, 2Turkiye/Bursa/TR"
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Turkish Neurosurgery, 2021
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Rhinology journal, 2017
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The Turkish Journal of Pediatrics, 2019
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Machine Learning in Clinical Neuroimaging and Radiogenomics in Neuro-oncology, 2020
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Frontiers in Oncology, 2022
ObjectiveMonitoring biomarkers using machine learning (ML) may determine glioblastoma treatment r... more ObjectiveMonitoring biomarkers using machine learning (ML) may determine glioblastoma treatment response. We systematically reviewed quality and performance accuracy of recently published studies.MethodsFollowing Preferred Reporting Items for Systematic Reviews and Meta-Analysis: Diagnostic Test Accuracy, we extracted articles from MEDLINE, EMBASE and Cochrane Register between 09/2018–01/2021. Included study participants were adults with glioblastoma having undergone standard treatment (maximal resection, radiotherapy with concomitant and adjuvant temozolomide), and follow-up imaging to determine treatment response status (specifically, distinguishing progression/recurrence from progression/recurrence mimics, the target condition). Using Quality Assessment of Diagnostic Accuracy Studies Two/Checklist for Artificial Intelligence in Medical Imaging, we assessed bias risk and applicability concerns. We determined test set performance accuracy (sensitivity, specificity, precision, F1-sc...
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CardioVascular and Interventional Radiology, 2015
The aim of this study was to investigate the effect of stent cell geometry on midterm results of ... more The aim of this study was to investigate the effect of stent cell geometry on midterm results of carotid artery stenting (CAS). One hundred fifty-five patients underwent CAS between February 2010 and December 2012. Ninety-one open- and 84 closed-cell stents were used in this non-randomized, retrospective study. Periprocedural complications were defined as the ones happened during the procedure or within 30 days afterwards. Starting from the 6th month after the procedure, in-stent restenosis was detected with multidetector computed tomography angiography and classified into four groups from focal restenosis to occlusion. Eleven complications were encountered in the periprocedural period (four on the open- and seven on the closed-cell group). Total complication rate was 6.3 % (11/175). No significant difference was detected in terms of periprocedural complications between two groups (p = 0.643). There was statistically significant difference between stent design groups in regard to radiological findings (p = 0.002). Sixteen of open-cell stents and three of closed-cell stents had focal restenosis. One closed-cell stent had diffuse proliferative restenosis and one open-cell stent had total occlusion. In-stent restenosis was more common in open-cell stent group, which have larger free cell area than closed-cell stents. Although our radiologic findings promote us to use closed-cell design if &amp;amp;#39;possible&amp;amp;#39;, no difference was detected in terms of clinical outcomes.
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Interventionelle Radiologie Scan
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Papers by Burcu Alparslan