Evolution has provided plants with sophisticated defensive strategies to &quo... more Evolution has provided plants with sophisticated defensive strategies to "perceive" attack by pathogens and insects, and to translate that "perception" into an appropriate adaptive response. Plant innate immunity is based on a surprisingly complex response that is highly flexible in its capacity to recognize and respond to the invader encountered. In the past years, we explored Arabidopsis as a model
The building blocks of bacterial flagella, flagellin monomers, are potent stimulators of host inn... more The building blocks of bacterial flagella, flagellin monomers, are potent stimulators of host innate immune systems. Recognition of flagellin monomers occurs by flagellin-specific pattern-recognition receptors, such as Toll-like receptor 5 (TLR5) in mammals and flagellin-sensitive 2 (FLS2) in plants. Activation of these immune systems via flagellin leads eventually to elimination of the bacterium from the host. In order to prevent immune activation and thus favor survival in the host, bacteria secrete many proteins that hamper such recognition. In our search for Toll like receptor (TLR) antagonists, we screened bacterial supernatants and identified alkaline protease (AprA) of Pseudomonas aeruginosa as a TLR5 signaling inhibitor as evidenced by a marked reduction in IL-8 production and NF-kB activation. AprA effectively degrades the TLR5 ligand monomeric flagellin, while polymeric flagellin (involved in bacterial motility) and TLR5 itself resist degradation. The natural occurring alk...
ABSTRACT Cadmium (Cd) is a widespread, naturally occurring element present in soil, rock, water, ... more ABSTRACT Cadmium (Cd) is a widespread, naturally occurring element present in soil, rock, water, plants and animals. Cd is a non-essential element for plants and is toxic at higher concentrations. Transcript profiles of roots of Arabidopsis thaliana (Arabidopsis) and Thlaspi caerulescens plants exposed to Cd and zinc (Zn) are examined, with the main aim to determine the differences in gene expression between the Cd-tolerant Zn-hyperaccumulator T. caerulescens and the Cd-sensitive non-accumulator Arabidopsis.
Molecular Aspects of Plant Disease Resistance, 2008
... Sjoerd van der Ent,* Annemart Koornneef,* Jurriaan ... See text for details. a more complex r... more ... Sjoerd van der Ent,* Annemart Koornneef,* Jurriaan ... See text for details. a more complex reality which can partially be explained by differences in experimental conditions, thereby making predictions about the outcome of such tripartite interactions difficult (Stout et al., 2006). ...
Evolution has provided plants with sophisticated defensive strategies to &quo... more Evolution has provided plants with sophisticated defensive strategies to "perceive" attack by pathogens and insects, and to translate that "perception" into an appropriate adaptive response. Plant innate immunity is based on a surprisingly complex response that is highly flexible in its capacity to recognize and respond to the invader encountered. In the past years, we explored Arabidopsis as a model
The building blocks of bacterial flagella, flagellin monomers, are potent stimulators of host inn... more The building blocks of bacterial flagella, flagellin monomers, are potent stimulators of host innate immune systems. Recognition of flagellin monomers occurs by flagellin-specific pattern-recognition receptors, such as Toll-like receptor 5 (TLR5) in mammals and flagellin-sensitive 2 (FLS2) in plants. Activation of these immune systems via flagellin leads eventually to elimination of the bacterium from the host. In order to prevent immune activation and thus favor survival in the host, bacteria secrete many proteins that hamper such recognition. In our search for Toll like receptor (TLR) antagonists, we screened bacterial supernatants and identified alkaline protease (AprA) of Pseudomonas aeruginosa as a TLR5 signaling inhibitor as evidenced by a marked reduction in IL-8 production and NF-kB activation. AprA effectively degrades the TLR5 ligand monomeric flagellin, while polymeric flagellin (involved in bacterial motility) and TLR5 itself resist degradation. The natural occurring alk...
ABSTRACT Cadmium (Cd) is a widespread, naturally occurring element present in soil, rock, water, ... more ABSTRACT Cadmium (Cd) is a widespread, naturally occurring element present in soil, rock, water, plants and animals. Cd is a non-essential element for plants and is toxic at higher concentrations. Transcript profiles of roots of Arabidopsis thaliana (Arabidopsis) and Thlaspi caerulescens plants exposed to Cd and zinc (Zn) are examined, with the main aim to determine the differences in gene expression between the Cd-tolerant Zn-hyperaccumulator T. caerulescens and the Cd-sensitive non-accumulator Arabidopsis.
Molecular Aspects of Plant Disease Resistance, 2008
... Sjoerd van der Ent,* Annemart Koornneef,* Jurriaan ... See text for details. a more complex r... more ... Sjoerd van der Ent,* Annemart Koornneef,* Jurriaan ... See text for details. a more complex reality which can partially be explained by differences in experimental conditions, thereby making predictions about the outcome of such tripartite interactions difficult (Stout et al., 2006). ...
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