Diagnosis of equine herpesvirus-1 associated myeloencephalopathy (EHM) can be troublesome, but ea... more Diagnosis of equine herpesvirus-1 associated myeloencephalopathy (EHM) can be troublesome, but early recognition and knowledge of risk factors are essential for prevention and control. The objectives for this study are to (1) describe EHM in France, (2) improve clinical recognition, (3) identify risk factors. Through epidemiosurveillance of acute neurological cases (all considered to be potentially infectious cases) in France (2008-2011), 26 EHM cases were identified and 29 EHM negative control cases. EHM cases were described and compared to controls with univariate, multivariate and classification and regression tree analysis. EHM cases had a 46% fatality rate and were frequently isolated cases. Most showed ataxia, paresis and a cauda equina syndrome, yet presence of other neurological signs was variable. Statistical analysis identified the following variables to be significantly associated to EHM compared to controls: introduction of a new horse to the herd, cauda equina syndrome, larger herd size, saddle horses and month of occurrence. The presence of many isolated cases, and less typical and variable clinical presentations emphasize the difficulty in diagnosing EHM. Nevertheless, history and clinical examination of acute neurological cases can be valuable in recognizing EHM early as well in order to select those cases that need further laboratory testing and infection control measures. Moreover, with a different study format and geographic location, risk factors were found to be similar to previous studies, therefore strengthening their significance to the spread of EHM.
... in poor to normal body condition are particularly prone to the condition and risk factors inc... more ... in poor to normal body condition are particularly prone to the condition and risk factors include cold, damp, frost-free weather ... Dominique Votion, Gaby van Galen, Atypical Myopathy Alert Group, Faculty of Veterinary Medicine, University of Liège, 4000 Liège, Belgium Celia M ...
The emergent nature of atypical myopathy or atypical myoglobinuria (AM) necessitates precise desc... more The emergent nature of atypical myopathy or atypical myoglobinuria (AM) necessitates precise description of its clinical and epidemiologic features. To define key features of AM to help practitioners recognize the disease and to advise owners to take preventive measures. Belgian cases of AM confirmed by histology (CC horses; n = 57) from autumn 2000 to spring 2005 were included in the study. Co-grazing horses (Co-G horses; n = 77) that remained free of any abnormal clinical signs constituted a control group. History, environmental characteristics, clinical signs, and laboratory results associated with AM were determined by a retrospective case series study. Young horses in poor or normal body condition were found to be at risk for AM. Pastures were characterized by poor natural drainage and vegetation of low nutritional value. Features of AM were seasonal occurrence, apparent link with weather conditions (ie, lack of solar radiation with no heavy frost and an excess of precipitation or relative humidity), sudden onset of clinical signs, and rapid death. Evaluation of serum creatine kinase activity indicated severe muscle destruction in CC horses and subclinical disease in a few Co-G horses. The association of AM with specific environmental conditions and individual animals suggests that young horses should not be pastured on bare premises subject to humidity when the weather has been very wet and cold for several days. Management of AM outbreaks should include control of Co-G horses who are apparently healthy.
... Gaby van Galen DVM, MSc, Dipl ECEIM a , Corresponding Author Contact Information , Géraldine ... more ... Gaby van Galen DVM, MSc, Dipl ECEIM a , Corresponding Author Contact Information , Géraldine Bolen DVM, PhD, Dipl ECVDI b , Denis Verwilghen ... 3 DA Jimenez, CR Berry, EA Ferrell and JP Graham, Imaging diagnosischoanal atresia in a dog, Vet Radiol Ultrasound 48 ...
Diagnosis of equine herpesvirus-1 associated myeloencephalopathy (EHM) can be troublesome, but ea... more Diagnosis of equine herpesvirus-1 associated myeloencephalopathy (EHM) can be troublesome, but early recognition and knowledge of risk factors are essential for prevention and control. The objectives for this study are to (1) describe EHM in France, (2) improve clinical recognition, (3) identify risk factors. Through epidemiosurveillance of acute neurological cases (all considered to be potentially infectious cases) in France (2008-2011), 26 EHM cases were identified and 29 EHM negative control cases. EHM cases were described and compared to controls with univariate, multivariate and classification and regression tree analysis. EHM cases had a 46% fatality rate and were frequently isolated cases. Most showed ataxia, paresis and a cauda equina syndrome, yet presence of other neurological signs was variable. Statistical analysis identified the following variables to be significantly associated to EHM compared to controls: introduction of a new horse to the herd, cauda equina syndrome, larger herd size, saddle horses and month of occurrence. The presence of many isolated cases, and less typical and variable clinical presentations emphasize the difficulty in diagnosing EHM. Nevertheless, history and clinical examination of acute neurological cases can be valuable in recognizing EHM early as well in order to select those cases that need further laboratory testing and infection control measures. Moreover, with a different study format and geographic location, risk factors were found to be similar to previous studies, therefore strengthening their significance to the spread of EHM.
... in poor to normal body condition are particularly prone to the condition and risk factors inc... more ... in poor to normal body condition are particularly prone to the condition and risk factors include cold, damp, frost-free weather ... Dominique Votion, Gaby van Galen, Atypical Myopathy Alert Group, Faculty of Veterinary Medicine, University of Liège, 4000 Liège, Belgium Celia M ...
The emergent nature of atypical myopathy or atypical myoglobinuria (AM) necessitates precise desc... more The emergent nature of atypical myopathy or atypical myoglobinuria (AM) necessitates precise description of its clinical and epidemiologic features. To define key features of AM to help practitioners recognize the disease and to advise owners to take preventive measures. Belgian cases of AM confirmed by histology (CC horses; n = 57) from autumn 2000 to spring 2005 were included in the study. Co-grazing horses (Co-G horses; n = 77) that remained free of any abnormal clinical signs constituted a control group. History, environmental characteristics, clinical signs, and laboratory results associated with AM were determined by a retrospective case series study. Young horses in poor or normal body condition were found to be at risk for AM. Pastures were characterized by poor natural drainage and vegetation of low nutritional value. Features of AM were seasonal occurrence, apparent link with weather conditions (ie, lack of solar radiation with no heavy frost and an excess of precipitation or relative humidity), sudden onset of clinical signs, and rapid death. Evaluation of serum creatine kinase activity indicated severe muscle destruction in CC horses and subclinical disease in a few Co-G horses. The association of AM with specific environmental conditions and individual animals suggests that young horses should not be pastured on bare premises subject to humidity when the weather has been very wet and cold for several days. Management of AM outbreaks should include control of Co-G horses who are apparently healthy.
... Gaby van Galen DVM, MSc, Dipl ECEIM a , Corresponding Author Contact Information , Géraldine ... more ... Gaby van Galen DVM, MSc, Dipl ECEIM a , Corresponding Author Contact Information , Géraldine Bolen DVM, PhD, Dipl ECVDI b , Denis Verwilghen ... 3 DA Jimenez, CR Berry, EA Ferrell and JP Graham, Imaging diagnosischoanal atresia in a dog, Vet Radiol Ultrasound 48 ...
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