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Open AccessLow-frequency ERK and Akt activity dynamics are predictive of stochastic cell division events
Understanding the dynamics of intracellular signaling pathways, such as ERK1/2 (ERK) and Akt1/2 (Akt), in the context of cell fate decisions is important for advancing our knowledge of cellular processes and d...
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Article
Open AccessOpen-Source System for Real-Time Functional Assessment of In Vitro Filtration Barriers
The integrity of the barrier between blood and the selective filtrate of solutes is important for homeostasis and its disruption contributes to many diseases. Microphysiological systems that incorporate synthe...
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Article
Open AccessNetwork inference from perturbation time course data
Networks underlie much of biology from subcellular to ecological scales. Yet, understanding what experimental data are needed and how to use them for unambiguously identifying the structure of even small netwo...
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Article
Open AccessRelating individual cell division events to single-cell ERK and Akt activity time courses
Biochemical correlates of stochastic single-cell fates have been elusive, even for the well-studied mammalian cell cycle. We monitored single-cell dynamics of the ERK and Akt pathways, critical cell cycle prog...
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Article
Open AccessValidating Antibodies for Quantitative Western Blot Measurements with Microwestern Array
Fluorescence-based western blots are quantitative in principal, but require determining linear range for each antibody. Here, we use microwestern array to rapidly evaluate suitable conditions for quantitative ...
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Article
Drug response consistency in CCLE and CGP