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2,652 Result(s)
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Article
EVA1A reverses lenvatinib resistance in hepatocellular carcinoma through regulating PI3K/AKT/p53 signaling axis
Lenvatinib is a commonly used first-line drug for the treatment of advanced hepatocellular carcinoma (HCC). However, its clinical efficacy is limited due to the drug resistance. EVA1A was a newly identified tu...
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Insulin-like growth factor binding protein-3 (igfbp-3) and igfbp-5 in yellowtail kingfish (Seriola lalandi): molecular characterization and expression levels under different nutritional status and stocking density
Insulin-like growth factor-binding proteins (IGFBPs) play important roles in regulating growth and development by binding to IGF, where IGFBP-3 and IGFBP-5 are the main binding carriers of IGF in the circulati...
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Open AccessHCMV IE1/IE1mut Therapeutic Vaccine Induces Tumor Regression via Intratumoral Tertiary Lymphoid Structure Formation and Peripheral Immunity Activation in Glioblastoma Multiforme
Glioblastoma multiforme (GBM), a highly malignant invasive brain tumor, is associated with poor prognosis and survival and lacks an effective cure. High expression of the human cytomegalovirus (HCMV) immediate...
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Characterization of adaptive expression regulation of yellowtail kingfish (Seriola lalandi) leptin, receptor, and receptor overlapping transcript genes in response to fasting and re-feeding strategies
Leptins and other related genes have been proven to play vital roles in food intake, weight control, and other life activities. While the function of leptins in yellowtail kingfish (Seriola lalandi) has not yet b...
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Open AccessFlavonoid metabolism plays an important role in response to lead stress in maize at seedling stage
Pb stress, a toxic abiotic stress, critically affects maize production and food security. Although some progress has been made in understanding the damage caused by Pb stress and plant response strategies, the...
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Open AccessEffect of phenylephrine versus ephedrine on the incidence of postoperative delirium in olderly adults undergoing knee arthroplasty under general anesthesia: a single-center trial
In addition to stabilizing blood pressure (BP), ephedrine and phenylephrine have distinct effects on regional cerebral oxygen saturation (rSO2). However, whether its effect on rSO2 affects the occurrence of posto...
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Open AccessVertically stacked skin-like active-matrix display with ultrahigh aperture ratio
Vertically stacked all-organic active-matrix organic light-emitting diodes are promising candidates for high-quality skin-like displays due to their high aperture ratio, extreme mechanical flexibility, and low...
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Open AccessThe sensitivity outcome index system for home care of elderly liver transplant patients was developed based on the Omaha problem classification system
Based on the Omaha problem classification system, a sensitivity outcome index system for home nursing of elderly liver transplant patients was established.
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Successful use of defibrotide to treat allogeneic hematopoietic stem cell transplantation associated thrombotic microangiopathy in pediatric patients: report from Chinese single center
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Open AccessEffects of genetically proxied statins on diabetic nephropathy and retinopathy: a Mendelian randomization study
There is no reliable causal evidence for the effect of statins on diabetic nephropathy (DN) and diabetic retinopathy (DR), and the results of previous observational studies are contradictory. Genetic variants ...
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Open AccessDistinct sources of uncertainty in simulations of the ocean biological carbon pump at different depths
Model uncertainty in simulating the biological carbon pump was quantified and partitioned using 14 models from the Coupled Model Intercomparison Project Phase 6. Uncertainty increases with depth. On the global...
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Open AccessNur77 improves ovarian function in reproductive aging mice by activating mitophagy and inhibiting apoptosis
Reproductive aging not only affects the fertility and physical and mental health of women but also accelerates the aging process of other organs. There is an urgent need newfor novel mechanisms, targets, and d...
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Article
Structure-Preserving Algorithm and Its Error Estimate for the Relativistic Charged-Particle Dynamics Under the Strong Magnetic Field
This paper investigates the numerical algorithm and its error estimates for the dynamics of relativistic charged particles under a strong maximal ordering scaling magnetic field. To maintain the fundamental pr...
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Disintegration of Cav-1/β-catenin complex attenuates neuronal death after ischemia–reperfusion injury by promoting β-catenin nuclear translocation
The roles of Caveolin-1 (Cav-1) and the Wnt/β-catenin signaling pathways in cerebral ischemia–reperfusion (I/R) injury are well established. The translocation of β-catenin into the nucleus is critical for regu...
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Extraction of Cynaroside from Honeysuckle by Nonionic Surfactant-Mediated Aqueous Extraction with Cloud Point Enrichment and Purification by Metal Complexation
Honeysuckle is rich in cynaroside (Cy), but its extraction and purification are difficult due to its poor solubility in water. Therefore, nonionic surfactants were used to extract Cy from honeysuckle plants, e...
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Open AccessHuman-induced warming accelerates local evapotranspiration and precipitation recycling over the Tibetan Plateau
The Tibetan Plateau faces changing precipitation and environmental conditions affecting alpine ecosystems and downstream freshwater sustainability. While aerosol influence has been highlighted, how human-induc...
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Nonexistence of quantum black and white hole horizons in an improved dynamic approach
In this paper, we study the quantum geometric effects near the locations where classical black hole horizons used to appear in Einstein’s classical theory, within the framework of an improved dynamic approach,...
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Open AccessProlonged administration of the granisetron transdermal delivery system reduces capecitabine plus oxaliplatin regimen induced nausea and vomiting
To evaluate the safety and efficacy of the granisetron transdermal delivery system (GTDS) combined with Dexamethasone for preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving Capeci...
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Open AccessRevolutionizing anemia detection: integrative machine learning models and advanced attention mechanisms
This study addresses the critical issue of anemia detection using machine learning (ML) techniques. Although a widespread blood disorder with significant health implications, anemia often remains undetected. T...
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Open AccessSynchronous Eurasian heat extremes tied to boreal summer combined extratropical intraseasonal waves
Heat extremes frequently hit different regions synchronously during boreal summer over the Eurasian continent. A remarkable coupling is first revealed between Eurasian heat extreme occurrence and individual ex...