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Article
Open AccessAssociations between epigenetic aging and diabetes mellitus in a Swedish longitudinal study
Diabetes mellitus type 2 (T2D) is associated with accelerated biological aging and the increased risk of onset of other age-related diseases. Epigenetic changes in DNA methylation levels have been found to ser...
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Article
Open AccessAutomated molecular structure segmentation from documents using ChemSAM
Chemical structure segmentation constitutes a pivotal task in cheminformatics, involving the extraction and abstraction of structural information of chemical compounds from text-based sources, including patent...
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Article
Open AccessHigh-Resolution Simulation of the Near-Field Pollutant Dispersion in a Nuclear Power Plant Community with High-Performance Computing
This study aims to employ numerical simulations to understand the dynamics of wind fields and air pollutant dispersion in the proximity of a nuclear plant, situated within a specified urban environment. By lev...
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Article
Chlorine-induced mixed valence of CuOx/C to promote the electroreduction of carbon dioxide to ethylene
Electrochemical conversion of CO2 (CO2RR) into high-value fuel is identified as one of the promising approaches to achieve carbon neutrality. The synthesis of high-efficiency CO2 reduction electrocatalysts with h...
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Article
Open AccessRepurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study
Despite increasing therapeutic options to treat rheumatoid arthritis (RA), many patients fail to reach treatment targets. The use of antidiabetic drugs like thiazolidinediones has been associated with lower RA...
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Article
Open AccessLongitudinal associations between use of antihypertensive, antidiabetic, and lipid-lowering medications and biological aging
Aging is a major risk factor for many chronic diseases. This study aimed to examine the effects of antihypertensive, lipid-lowering, and antidiabetic drugs on biological aging. We included 672 participants and...
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Chapter and Conference Paper
Balance Control for Inverted Pendulum System via SGCMG
It is crucial to study the self-balance problem of an inverted pendulum with non-holonomic constraints. For the balance control of inverted pendulum systems, there are now issues with insufficient robustness, ...
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Article
Sequential Enhancement for Compressed Video Using Deep Convolutional Generative Adversarial Network
Compression artifacts cause negative visual perception and are tough to reduce because of the balance between compressibility and fidelity. Despite extensive research on traditional methods, they take insuffic...
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Article
Open AccessDynamic patterns of blood lipids and DNA methylation in response to statin therapy
Statins are lipid-lowering drugs and starting treatment has been associated with DNA methylation changes at genes related to lipid metabolism. However, the longitudinal pattern of how statins affect DNA methyl...
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Article
Open AccessA genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome
The link underlying abnormal glucose metabolism, type 2 diabetes and polycystic ovary syndrome (PCOS) that is independent of BMI remains unclear in observational studies. We aimed to clarify this association u...
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Reference Work Entry In depth
Aging and Alzheimer’s Disease
Artificial intelligence (AI) implies the use of a machine with limited human interference to model intelligent actions. It covers a broad range of research studies from machine intelligence for computer vision...
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Chapter
Generative AI Models for Drug Discovery
A drug-like-molecule library can contain 1023–1060 molecules, among which only approximately 1012 molecules may be synthesized in labs. However, it is still challenging for researchers to find the most promising ...
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Living Reference Work Entry In depth
Ageing and Alzheimer’s Disease
Artificial intelligence (AI) implies the use of a machine with limited human interference to model intelligent actions. It covers a broad range of research studies from machine intelligence for computer vision...
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Article
Open AccessMajor depressive disorder and cardiometabolic diseases: a bidirectional Mendelian randomisation study
Observational studies have shown a bidirectional association between major depressive disorder (MDD) and cardiometabolic diseases. We conducted a two-sample bidirectional Mendelian randomisation (MR) study to ...
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Article
Open AccessA self-attention based message passing neural network for predicting molecular lipophilicity and aqueous solubility
Efficient and accurate prediction of molecular properties, such as lipophilicity and solubility, is highly desirable for rational compound design in chemical and pharmaceutical industries. To this end, we buil...
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Chapter and Conference Paper
Characteristics Extraction of Behavior of Multiplayers in Video Football Game
In the process of behavior recognition of multiplayers for soccer game video, various features of athletes need to be extracted. In this paper, color moments extracted by using color classification learning se...