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Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms
Smc5/6 is a member of the eukaryotic structural maintenance of chromosomes (SMC) family of complexes with important roles in genome maintenance and viral restriction. However, limited structural understanding ...
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Article
Open AccessSmc5/6’s multifaceted DNA binding capacities stabilize branched DNA structures
Smc5/6 is an evolutionarily conserved SMC complex with roles in DNA replication and repair, as well as in viral DNA restriction. Understanding its multiple functions has been hampered by a lack of mechanistic ...