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Article
Open AccessChromosome-level genome assembly and annotation of a potential model organism Gossypium arboreum ZB-1
Recent advancements in plant regeneration and synthetic polyploid creation have been documented in Gossypium arboreum ZB-1. These developments make ZB-1 a potential model within the Gossypium genus for investigat...
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Article
Open AccessA syrup containing l-arabinose and d-xylose appears superior to PEG-4000 as a bowel cleansing agent
Adequate bowel cleansing is crucial for endoscopic diagnosis and treatment, and the recovery of gut microbiota after intestinal cleansing is also important. A hypertonic syrup predominantly comprising l-arabinose...
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Article
A MYB transcription factor GhTT2 of Gossypium hirsutum regulates proanthocyanidin accumulation and improves osmotic tolerance in Arabidopsis
Several MYB transcription factors have been identified as the regulators of proanthocyanidin biosynthesis in plants. However, limited research has been conducted on the functional characterization of MYBs invo...
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Article
Open AccessAn insight into the gene expression evolution in Gossypium species based on the leaf transcriptomes
Gene expression pattern is associated with biological phenotype and is widely used in exploring gene functions. Its evolution is also crucial in understanding species speciation and divergence. The genus Gossy...
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Article
Open AccessSerum metabolomics of hyperbilirubinemia and hyperuricemia in the Tibetan plateau has unique characteristics
Few studies have provided data on the metabolomics characteristics of metabolic diseases such as hyperuricemia and hyperbilirubinemia in the Tibetan plateau. In the current study, we sought to investigate the ...
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Article
Sef1, rapid-cycling Brassica napus for large-scale functional genome research in a controlled environment
We demonstrated a short-cycle B. napus line, Sef1, with a highly efficient and fast transformation system, which has great potential in large-scale functional gene analysis in a controlled environment.
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Article
Open AccessThe landscape of the long non-coding RNAs in developing mouse retinas
The long non-coding RNAs (lncRNAs) are critical regulators of diverse biological processes. Nevertheless, a global view of its expression and function in the mouse retina, a crucial model for neurogenesis stud...
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Article
Identification and Functional Analysis of the Promoter of a Leucoanthocyanidin Reductase Gene from Gossypium hirsutum
Leucoanthocyanidin reductase (LAR) is the critical enzyme in the synthesis pathway of proanthocyanidins, which are the primary pigments in brown cotton fibers. Our previous study has revealed significant diffe...
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Article
Open AccessComparison of fully coated anti-reflux metal stenting and per-oral endoscopic myotomy in patients with achalasia: a propensity score-matched retrospective study
Achalasia is a rare primary esophageal motility disorder disease. It is reported that the long-term effect of fully coated anti-reflux metal stent (FCARMS) implantation is satisfactory. Operated by a skilled a...
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Article
Plant regeneration via somatic embryogenesis in diploid cultivated cotton (Gossypium arboreum L.)
The diploid cotton species G. arboreum offers a better opportunity to elucidate gene structure and function as opposed to the allotetraploid cotton species. As a prerequisite for this, a reliable and efficient me...
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Article
Identification and functional analysis of a pollen fertility-associated gene GhGLP4 of Gossypium hirsutum L.
Cotton male fertility-associated gene GhGLP4, encoding a germin-like protein, is essential for anthers development by keeping ROS homeostasis through reducing H2O2 level.
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Article
Open AccessGATA3 maintains the quiescent state of cochlear supporting cells by regulating p27kip1
Haplo-insufficiency of the GATA3 gene causes hypoparathyroidism, sensorineural hearing loss, and renal disease (HDR) syndrome. Previous studies have shown that Gata3 is required for the development of the prosens...
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Article
Open AccessSystematic review and meta-analysis of video-assisted thoracoscopic surgery segmentectomy versus lobectomy for stage I non–small cell lung cancer
Whether video-assisted thoracoscopic surgery (VATS) segmentectomy and VATS lobectomy provide similar perioperative and oncological outcomes in stage I non–small cell lung cancer (NSCLC) is still controversial.
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Article
Open AccessGenome-wide identification of cold responsive transcription factors in Brassica napus L
Cold stress is one of the primary environmental factors that affect plant growth and productivity, especially for crops like Brassica napus that live through cold seasons. Till recently, although a number of gene...
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Article
Open AccessSystematic identification of intergenic long-noncoding RNAs in mouse retinas using full-length isoform sequencing
A great mass of long noncoding RNAs (lncRNAs) have been identified in mouse genome and increasing evidences in the last decades have revealed their crucial roles in diverse biological processes. Nevertheless, ...
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Article
Open AccessPmiRDiscVali: an integrated pipeline for plant microRNA discovery and validation
MicroRNAs (miRNAs) constitute a well-known small RNA (sRNA) species with important regulatory roles. To date, several bioinformatics tools have been developed for large-scale prediction of miRNAs based on high...
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Article
Open AccessGefitinib provides similar effectiveness and improved safety than erlotinib for east Asian populations with advanced non–small cell lung cancer: a meta-analysis
The first-generation epidermal growth factor receptor tyrosine kinase inhibitors gefitinib and erlotinib have both been proven effective for treating advanced non–small cell lung cancer (NSCLC), especially in ...
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Article
Evidence of the genetic diversity and clonal population structure of Oenococcus oeni strains isolated from different wine-making regions of China
Studies of the genetic diversity and population structure of Oenococcus oeni (O. oeni) strains from China are lacking compared to other countries and regions. In this study, amplified fragment length polymorphism...
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Article
Transcriptome-wide identification and characterization of the copper and cadmium stress-responsive small RNAs and their targets in Arabidopsis thaliana
Copper (Cu) and cadmium (Cd) are toxic to plants at high levels. The current situation that many crops are growing on the farmlands with Cu or Cd contamination leads to a big threat to food safety.
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Open AccessBioinformatics resources for deciphering the biogenesis and action pathways of plant small RNAs
The next-generation sequencing (NGS) technology has revolutionized our previous understanding of the plant genomes, relying on its innate advantages, such as high throughput and deep sequencing depth. In addit...