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Article
Open AccessAssociation of body mass index with mortality of sepsis or septic shock: an updated meta-analysis
The effects of body mass index (BMI) on mortality of sepsis remain unknown, since previous meta-analyses have reported conflicting results. Several observational studies published recently have provided new ev...
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Chapter and Conference Paper
Anchor Link Prediction Based on Trusted Anchor Re-identification
Cross-social network anchor link prediction plays a pivotal role in downstream tasks, such as comprehensively portraying user characteristics, user friend recommendations, and online public opinion analysis, w...
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Chapter and Conference Paper
PTSTEP: Prompt Tuning for Semantic Typing of Event Processes
Giving machines the ability to understand the intent of human actions is a basic goal of Natural Language Understanding. In the context of that, a task called the Multi-axis Event Processes Typing is proposed,...
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Article
Open AccessHistone citrullination: a new target for tumors
As the main protein components of chromatin, histones play central roles in gene regulation as spools of winding DNA. Histones are subject to various modifications, including phosphorylation, acetylation, glyc...
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Chapter and Conference Paper
Robust Retinal Vessel Segmentation from a Data Augmentation Perspective
Retinal vessel segmentation is a fundamental step in screening, diagnosis, and treatment of various cardiovascular and ophthalmic diseases. Robustness is one of the most critical requirements for practical uti...
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Article
Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation. Here, we identify an additional activity of R-2-HG: ...
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Article
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism
Metabolic changes in T cells can affect the genomic methylation status of key transcription factors and regulate the fate decision between induced regulatory T cells and T helper 17 cells.
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Chapter and Conference Paper
The Analysis and Modeling of Intersystem Biases Between GPS and BDS
Receiver hardware delay is one of the error sources which affect ambiguity resolution and positioning. In this contribution, differential receiver hardware delay between GPS and BDS, namely differential phase ...
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Article
Open AccessA small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model
D-2-hydroxyglutaric aciduria (D2HGA) type II is a rare neurometabolic disorder caused by germline gain-of-function mutations in isocitrate dehydrogenase 2 (IDH2), resulting in accumulation of D-2-hydroxyglutarate...