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Article
Open AccessThe combined treatment with ketogenic diet and metformin slows tumor growth in two mouse models of triple negative breast cancer
Many tumors contain hypoxic microenvironments caused by inefficient tumor vascularization. Hypoxic tumors have been shown to resist conventional cancer therapies. Hypoxic cancer cells rely on glucose to meet t...
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Article
Open AccessGut microbiome remodeling and metabolomic profile improves in response to protein pacing with intermittent fasting versus continuous caloric restriction
The gut microbiome (GM) modulates body weight/composition and gastrointestinal functioning; therefore, approaches targeting resident gut microbes have attracted considerable interest. Intermittent fasting (IF)...
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Article
Targeted metabolomics reveals plasma biomarkers and metabolic alterations of the aging process in healthy young and older adults
With the exponential growth in the older population in the coming years, many studies have aimed to further investigate potential biomarkers associated with the aging process and its incumbent morbidities. Age...
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Article
Open AccessBiomass smoke inhalation promotes neuroinflammatory and metabolomic temporal changes in the hippocampus of female mice
Smoke from wildland fires has been shown to produce neuroinflammation in preclinical models, characterized by neural infiltrations of neutrophils and monocytes, as well as altered neurovascular endothelial phe...
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Article
Open AccessMulti-omic assessment shows dysregulation of pulmonary and systemic immunity to e-cigarette exposure
Electronic cigarette (Ecig) use has become more common, gaining increasing acceptance as a safer alternative to tobacco smoking. However, the 2019 outbreak of Ecig and Vaping-Associated Lung Injury (EVALI) ale...
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Article
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration
Astrocytes provide key neuronal support, and their phenotypic transformation is implicated in neurodegenerative diseases. Metabolically, astrocytes possess low mitochondrial oxidative phosphorylation (OxPhos) ...
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Article
Open AccessAssociation of food insecurity on gut microbiome and metabolome profiles in a diverse college-based sample
Voluntary caloric restriction (e.g., eating disorders) often results in alterations in the gut microbiota composition and function. However, these findings may not translate to food insecurity, where an indivi...
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Article
Open AccessMicrobiome and metabolome profiles of high screen time in a cohort of healthy college students
As screens are increasingly integrated into every facet of modern life, there is growing concern over the potential effects of high screen time. Previous studies have largely utilized self-report data on mood ...
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Article
Open AccessCadmium exposure modulates the gut-liver axis in an Alzheimer’s disease mouse model
The human Apolipoprotein E4 (ApoE4) variant is the strongest known genetic risk factor for Alzheimer’s disease (AD). Cadmium (Cd) has been shown to impair learning and memory at a greater extent in humanized A...
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Article
Evaluation of potential metabolomic-based biomarkers of protein, carbohydrate and fat intakes using a controlled feeding study
Objective biomarkers of dietary exposure are needed to establish reliable diet-disease associations. Unfortunately, robust biomarkers of macronutrient intakes are scarce. We aimed to assess the utility of ser...
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Open AccessProtocol of the Snuggle Bug/Acurrucadito Study: a longitudinal study investigating the influences of sleep-wake patterns and gut microbiome development in infancy on rapid weight gain, an early risk factor for obesity
Overweight, obesity, and associated comorbidities are a pressing global issue among children of all ages, particularly among low-income populations. Rapid weight gain (RWG) in the first 6 months of infancy con...
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Protocol
Metabolomics Analysis of Viral Therapeutics
Virotherapy, enabled by recent advances in the transdisciplinary field of biotechnology, has emerged as a powerful tool for use in anticancer treatment, gene therapy, immunotherapy, etc. Examining the effects ...
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Article
Identification of major malate export systems in an engineered malate-producing Escherichia coli aided by substrate similarity search
Optimization of export mechanisms for valuable extracellular products is important for the development of efficient microbial production processes. Identification of the relevant export mechanism is the prereq...
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Article
Open AccessGlucose promotes cell growth by suppressing branched-chain amino acid degradation
Glucose and branched-chain amino acids (BCAAs) are essential nutrients and key determinants of cell growth and stress responses. High BCAA level inhibits glucose metabolism but reciprocal regulation of BCAA me...
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Article
Altered metabolite levels and correlations in patients with colorectal cancer and polyps detected using seemingly unrelated regression analysis
Metabolomics technologies enable the identification of putative biomarkers for numerous diseases; however, the influence of confounding factors on metabolite levels poses a major challenge in moving forward wi...
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Article
Open AccessMetabolic Effects of Clenbuterol and Salbutamol on Pork Meat Studied Using Internal Extractive Electrospray Ionization Mass Spectrometry
Direct mass spectrometry analysis of metabolic effects of clenbuterol and salbutamol on pork quality at the molecular level is incredibly beneficial for food regulations, public health and the development of n...
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Article
Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett’s esophagus, and high-grade dysplasia/esophageal adenocarcinoma
Incidence of esophageal adenocarcinoma (EA), an often fatal cancer, has increased sharply over recent decades. Several important risk factors (reflux, obesity, smoking) have been identified for EA and its prec...
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Article
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition
For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types. Recently, it has been recognized that embryonic st...
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Article
Targeted serum metabolite profiling and sequential metabolite ratio analysis for colorectal cancer progression monitoring
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and a major cause of human morbidity and mortality. In addition to early detection, close monitoring of disease progression in CRC can be ...
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Article
Open AccessQuantitative detection of nitric oxide in exhaled human breath by extractive electrospray ionization mass spectrometry
Exhaled nitric oxide (eNO) is a useful biomarker of various physiological conditions, including asthma and other pulmonary diseases. Herein a fast and sensitive analytical method has been developed for the qua...