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Open AccessMagnetic targeting enhances the neuroprotective function of human mesenchymal stem cell-derived iron oxide exosomes by delivering miR-1228-5p
Treating mitochondrial dysfunction is a promising approach for the treatment of post-stroke cognitive impairment (PSCI). HuMSC-derived exosomes (H-Ex) have shown powerful therapeutic effects in improving mitoc...
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Article
Effect of Gadolinium on Inclusions and Microstructure of an Al-Killed High Sulfur Steel Used for the Connecting Rod of Engines
The effect of the total gadolinium (T.Gd) content on the microstructure, inclusions, and the size of austenite grains of the high sulfur steel was investigated. Primary inclusions in the steel without gadolini...
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Article
Effect of Gadolinium on Inclusions in a High-Sulfur Free-Cutting Steel and Converting Two-Dimensional to Three-Dimensional Morphology of Inclusions Through Matlab Programming
The influence of the various rare earth element gadolinium contents on inclusions, microstructure, and hardness of free-cutting Y15Mn steel was investigated. And the Matlab programming was explored to provide ...
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Article
Open AccessEnhancing gadoxetic acid–enhanced liver MRI: a synergistic approach with deep learning CAIPIRINHA-VIBE and optimized fat suppression techniques
To investigate whether a deep learning (DL) controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA)-volumetric interpolated breath-hold examination (VIBE) technique can improve imag...
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Open AccessAuthor Correction: PLMSearch: Protein language model powers accurate and fast sequence search for remote homology
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Open AccessMRI-based prediction of the need for wide resection margins in patients with single hepatocellular carcinoma
To develop an MRI-based score that enables individualized predictions of the survival benefit of wide over narrow resection margins.
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Article
Effect of Gadolinium on the Deformation of Sulfides and Mechanical Properties of an Al-Killed Resulfurized Steel
The rare earth element Gd was added into a resulfurized steel to enhance its performance. Non-metallic inclusions in the steel, the hardness and the microstructure of the steel were analyzed. The addition of G...
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Article
Open AccessPterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation
Stroke is a type of acute brain damage that can lead to a series of serious public health challenges. Demonstrating the molecular mechanism of stroke-related neural cell degeneration could help identify a more...
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Article
Open AccessRetinal microvascular changes in patients with pancreatitis and their clinical significance
Acute pancreatitis, a common exocrine inflammatory disease affecting the pancreas, is characterized by intense abdominal pain and multiple organ dysfunction. However, the alterations in retinal blood vessels a...
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Article
Development of a dual-template molecularly imprinted electrochemical sensor for the simultaneous detection of depression markers 5-HT and Glu
A dual-template molecularly imprinted electrochemical sensor was developed for the simultaneous detection of serotonin (5-HT) and glutamate (Glu). First, amino-functionalized reduced graphene oxide (NRGO) was ...
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Article
The Cumulative Damage Evolution Law Of Multi-Anchor Circular Piles Reinforced Landslide Under Earthquake Action
To study the cumulative damage evolution law of multi-anchor circular piles (MACP) under earthquake action, data such as acceleration and axial force of anchor cables of MACP were obtained by shaking table tes...
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Article
Open AccessDeep learning-based 3D quantitative total tumor burden predicts early recurrence of BCLC A and B HCC after resection
This study aimed to evaluate the potential of deep learning (DL)-assisted automated three-dimensional quantitative tumor burden at MRI to predict postoperative early recurrence (ER) of hepatocellular carcinoma...
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Article
Open AccessResilience and adaptation: a mixed-methods exploration of COVID-19’s influence on neonatal residency education in China
This study aimed to assess the impact of the pandemic of the coronavirus disease 2019 (COVID-19) on neonatology residency training in a tertiary children’s hospital in Chongqing, located in southwest China. Sp...
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Open AccessCorrection: A methylation‑ and immune‑related lncRNA signature to predict ovarian cancer outcome and uncover mechanisms of chemoresistance
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Open AccessMRI radiomics based on deep learning automated segmentation to predict early recurrence of hepatocellular carcinoma
To investigate the utility of deep learning (DL) automated segmentation-based MRI radiomic features and clinical-radiological characteristics in predicting early recurrence after curative resection of single h...
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Article
Open AccessMicroglia-derived exosomes selective sorted by YB-1 alleviate nerve damage and cognitive outcome in Alzheimer’s disease
Neuroinflammation is a characteristic pathological change of Alzheimer’s Diseases (AD). Microglia have been reported to participate in inflammatory responses within the central nervous system. However, the mec...
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Article
Open AccessMetformin attenuates lung ischemia-reperfusion injury and necroptosis through AMPK pathway in type 2 diabetic recipient rats
Diabetes mellitus (DM) can aggravate lung ischemia-reperfusion (I/R) injury and is a significant risk factor for recipient mortality after lung transplantation. Metformin protects against I/R injury in a varie...
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Article
Effect of oxide inclusions on MnS precipitates and tensile mechanical property of high-strength low-alloy steel
The key role of oxide inclusions on the microstructure and mechanical property of a high-strength low-alloy steel was investigated. The field emission scanning electron microscope equipped with energy-dispersi...
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Article
Open AccessPrognostic MRI features to predict postresection survivals for very early to intermediate stage hepatocellular carcinoma
Contrast-enhanced MRI can provide individualized prognostic information for hepatocellular carcinoma (HCC). We aimed to investigate the value of MRI features to predict early (≤ 2 years)/late (> 2 years) recur...
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Article
High-fat diet impairs gut barrier through intestinal microbiota-derived reactive oxygen species
Gut barrier disruption is a key event in bridging gut microbiota dysbiosis and high-fat diet (HFD)-associated metabolic disorders. However, the underlying mechanism remains elusive. In the present study, by co...
