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Open AccessBispecific immune molecule PD1-IL2v: a new therapeutic strategy for pancreatic ductal adenocarcinoma
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Open AccessFAP senescence: a critical event in muscle regeneration
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Open AccessKetogenic diet: new avenues to overcome colorectal cancer
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Open AccessImprovement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages
Pro-inflammatory activation of adipose tissue macrophages (ATMs) is causally linked to obesity and obesity-associated disorders. A number of studies have demonstrated the crucial role of mitochondrial metaboli...
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Lipid Metabolism in Tumor-Associated Macrophages
Macrophages are essential components of the immune system in tumors. It can be recruited and educated to two mainly polarized subpopulations (M1-like and M2-like) of tumor-associated macrophages (TAMs) to disp...
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Open AccessDietary fats suppress the peritoneal seeding of colorectal cancer cells through the TLR4/Cxcl10 axis in adipose tissue macrophages
Peritoneal carcinomatosis (PC) of colorectal cancer (CRC) is a terminal phase of malignancy with no effective strategies for the prevention of this condition. Here we established PC models in mice by intraperi...
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Open AccessTargeting metabolic/epigenetic pathways: a potential strategy for cancer therapy in diffuse intrinsic pontine gliomas
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Open AccessDietary intervention, a promising adjunct for cancer therapy
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Open AccessCorrection: Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessLymphopenia predicts disease severity of COVID-19: a descriptive and predictive study
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Open AccessThe Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages
Lipid metabolic reprogramming plays an essential role in regulating the progression of colorectal cancer (CRC). However, the effect of lysophosphatidic acid (LPA) metabolism on CRC development is incompletely ...
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Open AccessCordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents
The pathological mechanisms of radiation ulcer remain unsolved and there is currently no effective medicine. Here, we demonstrate that persistent DNA damage foci and cell senescence are involved in radiation u...
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Open AccessTranscriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect
The human positive cofactor 4 (PC4) is initially identified as a transcriptional cofactor and has an important role in embryonic development and malignant transformation. However, the clinical significance and...
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Open AccessMonoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
Metabolic reprogramming greatly contributes to the regulation of macrophage activation. However, the mechanism of lipid accumulation and the corresponding function in tumor-associated macrophages (TAMs) remain...
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Article
Open AccessNF-κB potentiates tumor growth by suppressing a novel target LPTS
Chronic inflammation is causally linked to the carcinogenesis and progression of most solid tumors. LPTS is a well-identified tumor suppressor by inhibiting telomerase activity and cancer cell growth. However,...
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Open AccessMacrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
Metabolic reprogramming in stromal cells plays an essential role in regulating tumour growth. The metabolic activities of tumour-associated macrophages (TAMs) in colorectal cancer (CRC) are incompletely charac...
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Open AccessStearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes
The biomechanics stress and chronic inflammation in obesity are causally linked to osteoarthritis. However, the metabolic factors mediating obesity-related osteoarthritis are still obscure. Here we scanned and...
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FOXO1 involvement in insulin resistance-related pro-inflammatory cytokine production in hepatocytes
Low-grade inflammation from hepatocytes plays a causal role in hepatic and systemic insulin resistance (IR). We aimed to explore whether and how FOXO1 was involved in IR-related inflammation in hepatocytes.