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Motion-based DNA detection using catalytic nanomotors
Synthetic nanomotors, which convert chemical energy into autonomous motion, hold considerable promise for diverse applications. In this paper, we show the use of synthetic nanomotors for detecting DNA and bact...
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Article
Open AccessCharacterization of Induced Neural Progenitors from Skin Fibroblasts by a Novel Combination of Defined Factors
Recent reports have demonstrated that somatic cells can be directly converted to other differentiated cell types through ectopic expression of sets of transcription factors, directly avoiding the transition th...
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Article
Open AccessJAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations
Cancer-associated protein tyrosine kinase (PTK) mutations usually are gain-of-function (GOF) mutations that drive tumor growth and metastasis. We have found 50 JAK1 truncating mutations in 36 of 635 gynecologi...
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Open AccessRatiometric electrochemical proximity assay for sensitive one-step protein detection
This work proposes the concept of ratiometric electrochemical proximity assay (REPA), which can be used for one-step, highly sensitive and selective detection of protein. The assay strategy was achieved on a s...
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Article
Chd5 orchestrates chromatin remodelling during sperm development
One of the most remarkable chromatin remodelling processes occurs during spermiogenesis, the post-meiotic phase of sperm development during which histones are replaced with sperm-specific protamines to repacka...
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Open AccessInterleukin-17 inhibits Adult Hippocampal Neurogenesis
Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain ...
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Article
Open AccessIntegrative analysis of 111 reference human epigenomes
The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap...
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Open AccessAnti-Human H1N1pdm09 and swine H1N1 Virus Antibodies among Swine Workers in Guangdong Province, China
To assess the potential transmission for zoonotic influenza, sero-antibodies against two kinds of influenza viruses—classical swine H1N1 and human H1N1pdm09 virus were detected in persons whose profession invo...
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Article
Open AccessRole of Src in Vascular Hyperpermeability Induced by Advanced Glycation End Products
The disruption of microvascular barrier in response to advanced glycation end products (AGEs) stimulation contributes to vasculopathy associated with diabetes mellitus. Here, to study the role of Src and its a...
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Article
Open AccessAssociations between Sleep Duration and Overweight/Obesity: Results from 66,817 Chinese Adolescents
The findings about the shapes of associations between sleep duration and overweight/obesity in adolescents were largely inconsistent in the existing literature. We examined the functional forms of the associat...
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Article
Open AccessThe role, mechanism and potentially novel biomarker of microRNA-17-92 cluster in macrosomia
Macrosomia is one of the most common perinatal complications of pregnancy and has life-long health implications for the infant. microRNAs (miRNAs) have been identified to regulate placental development, yet th...
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Article
Open AccessGinseng alleviates cyclophosphamide-induced hepatotoxicity via reversing disordered homeostasis of glutathione and bile acid
Cyclophosphamide (CP), a chemotherapeutic agent, is restricted due to its side effects, especially hepatotoxicity. Ginseng has often been clinically used with CP in China, but whether and how ginseng reduces t...
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Article
Open AccessFlavone synthases from Lonicera japonica and L. macranthoides reveal differential flavone accumulation
Flavones are important secondary metabolites found in many plants. In Lonicera species, flavones contribute both physiological and pharmaceutical properties. However, flavone synthase (FNS), the key enzyme respon...
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Article
Open AccessModulation of IL-1β reprogrammes the tumor microenvironment to interrupt oral carcinogenesis
Head and neck squamous cell carcinoma (HNSCC) development is a multistage process includes the normal, dysplasia and squamous cell carcinoma (SCC) stages. Recently, increasing evidence has suggested that the t...
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Open AccessGut microbiota-involved mechanisms in enhancing systemic exposure of ginsenosides by coexisting polysaccharides in ginseng decoction
Oral decoctions of traditional Chinese medicines (TCMs) serve for therapeutic and prophylactic management of diseases for centuries. Small molecules and polysaccharides are the dominant chemicals co-occurred i...
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Article
Open AccessA “building block” approach to the new influenza A virus entry inhibitors with reduced cellular toxicities
Influenza A virus (IAV) is a severe worldwide threat to public health and economic development that results in the emergence of drug-resistant or highly virulent strains. Therefore, it is imperative to develop...
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Open AccessImpact of aortocaval shunt flow on cardiac and renal function in unilateral nephrectomized rats
We previously reported significantly enhanced cardiac remodeling post aortocaval fistula (AV) in unilateral nephrectomized (UNX) rats. However, the relationship between the size of the AV and the cardiorenal e...
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Article
Open AccessOverexpression of Arabidopsis NLP7 improves plant growth under both nitrogen-limiting and -sufficient conditions by enhancing nitrogen and carbon assimilation
Nitrogen is essential for plant survival and growth. Excessive application of nitrogenous fertilizer has generated serious environment pollution and increased production cost in agriculture. To deal with this ...
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Open AccessCannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca2+ oscillations in mouse pancreatic acinar cells
Emerging evidence demonstrates that the blockade of intracellular Ca2+ signals may protect pancreatic acinar cells against Ca2+ overload, intracellular protease activation, and necrosis. The activation of cannabi...
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Open AccessNicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms
There is much interest in brain regions that drive nicotine intake in smokers. Interestingly, both the rewarding and aversive effects of nicotine are probably critical for sustaining nicotine addiction. The me...