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Article
Open AccessRab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness
Liver kinase B1 (LKB1) is frequently mutated in lung adenocarcinoma, and its loss contributes to tumor progression.
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Article
Evidence for d-wave superconductivity of infinite-layer nickelates from low-energy electrodynamics
The discovery of superconductivity in infinite-layer nickelates established another category of unconventional superconductors that shares structural and electronic similarities with cuprates. However, key iss...
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Article
Open AccessThe development of a novel zeolite-based assay for efficient and deep plasma proteomic profiling
Plasma proteins are considered the most informative source of biomarkers for disease diagnosis and monitoring. Mass spectrometry (MS)-based proteomics has been applied to identify biomarkers in plasma, but the...
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Article
Open AccessCordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway
To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC).
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Article
Open AccessChemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis
Malaria remains a global health burden, and the emergence and increasing spread of drug resistance to current antimalarials poses a major challenge to malaria control. There is an urgent need to find new drugs...
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Article
Open AccessDopamine modification of glycolytic enzymes impairs glycolysis: possible implications for Parkinson’s disease
Parkinson’s disease (PD), a chronic and severe neurodegenerative disease, is pathologically characterized by the selective loss of nigrostriatal dopaminergic neurons. Dopamine (DA), the neurotransmitter produc...
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Article
Open AccessChirality manipulation of ultrafast phase switches in a correlated CDW-Weyl semimetal
Light engineering of correlated states in topological materials provides a new avenue of achieving exotic topological phases inaccessible by conventional tuning methods. Here we demonstrate a light control of ...
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Article
Benign Metastasizing Leiomyoma: Is “Wait and Watch” Strategy Feasible?
Benign metastasizing leiomyoma (BML) is a rare disease that affects women with a history of uterine leiomyoma. The aim of this study is to investigate the clinical characteristics and outcome patterns. We coll...
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Article
Open AccessTargeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy
Imaging-guided photothermal therapy (PTT) for cancers recently gathered increasing focus thanks to its precise diagnosis and potent therapeutic effectiveness. Croconaine (CR) dyes demonstrate potential in expa...
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Article
Open AccessAb-initio simulations of coherent phonon-induced pumping of carriers in zirconium pentatelluride
Laser-driven coherent phonons can act as modulated strain fields and modify the adiabatic ground state topology of quantum materials. Here we use time-dependent first-principles and effective model calculation...
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Article
Open AccessCryo-EM structure of severe fever with thrombocytopenia syndrome virus
The severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne human-infecting bunyavirus, which utilizes two envelope glycoproteins, Gn and Gc, to enter host cells. However, the structure and o...
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Article
Open AccessMultifunctional nanozyme-reinforced copper-coordination polymer nanoparticles for drug-resistance bacteria extinction and diabetic wound healing
Drug-resistant bacterial infections in chronic wounds are a persistent issue, as they are resistant to antibiotics and can cause excessive inflammation due to generation of reactive oxygen species (ROS). An ef...
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Article
Open AccessResearch progress on the role of extracellular vesicles in neurodegenerative diseases
Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease, affect millions of people worldwide. Tremendous efforts have been put into...
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Article
Cholesterol modulates the physiological response to nanoparticles by changing the composition of protein corona
Nanoparticles (NPs) in biological fluids form a layer of biomolecules known as the protein corona. The protein corona has been shown to determine the biological identity and in vivo fate of NPs, but whether an...
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Article
Open AccessBeyond canonical PROTAC: biological targeted protein degradation (bioTPD)
Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential to modulate disease-associated proteins that have previously been considered undruggable, by employing the host destruc...
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Article
Open AccessVisualizing heterogeneous dipole fields by terahertz light coupling in individual nano-junctions
The challenge underlying superconducting quantum computing is to remove materials bottleneck for highly coherent quantum devices. The nonuniformity and complex structural components in the underlying quantum c...
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Article
The neuroprotective effects of peracetylated chitosan oligosaccharides against β-amyloid-induced cognitive deficits in rats
Chitosan oligosaccharides (COSs) have been reported to possess a broad range of activities such as antitumor, antioxidant and neuroprotective activities. In this study, the protective effects and mechanisms of...
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Article
Open AccessSingle-cell transcriptome analysis reveals liver injury induced by glyphosate in mice
Glyphosate (GLY), as the active ingredient of the most widely used herbicide worldwide, is commonly detected in the environment and living organisms, including humans. Its toxicity and carcinogenicity in mamma...
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Chapter and Conference Paper
Simplifying Aspect-Sentiment Quadruple Prediction with Cartesian Product Operation
Aspect sentiment quad prediction (ASQP) is an emerging subtask of aspect-based sentiment analysis, which seeks to predict the sentiment quadruplets of aspect terms, aspect categories, associated sentiment pola...
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Article
Open AccessCDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin
It is highly desirable to develop new therapeutic strategies for gastric cancer given the low survival rate despite improvement in the past decades. Cadherin 17 (CDH17) is a membrane protein highly expressed i...