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261 Result(s)
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Open AccessGenotype-phenotype spectrum and correlation of PHARC Syndrome due to pathogenic ABHD12 variants
A comprehensive understanding of the genetic basis of rare diseases and their regulatory mechanisms is essential for human molecular genetics. However, the genetic mutant spectrum of pathogenic genes within th...
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Theory of Lipid Metabolism Disorders in Rhinitis and Asthma (Lipid Droplets)
Lipid droplets are important for the storage of neutral lipids in cells; moreover, they participate in a variety of activities in cells and are multifunctional organelles. In the past few decades, lipid drople...
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Open AccessPublisher Correction: Amplified positive effects on air quality, health, and renewable energy under China’s carbon neutral target
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Establishing and Validating an Innovative Focal Adhesion-Linked Gene Signature for Enhanced Prognostic Assessment in Endometrial Cancer
Studies have highlighted the significant role of focal adhesion signaling in cancer. Nevertheless, its specific involvement in the pathogenesis of endometrial cancer and its clinical significance remains uncer...
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Open AccessOptimal scheduling model using the IGDT method for park integrated energy systems considering P2G–CCS and cloud energy storage
To enhance the energy efficiency and financial gains of the park integrated energy system (PIES). This paper constructs a bi-level optimization model of PIES-cloud energy storage (CES) based on source-load unc...
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Open AccessMxene-bpV plays a neuroprotective role in cerebral ischemia-reperfusion injury by activating the Akt and promoting the M2 microglial polarization signaling pathways
Studies have shown that the inhibition of phosphatase and tensin homolog deleted on chromosome 10 (PTEN)was neuroprotective against ischemia/reperfusion(I/R) injury. Bisperoxovanadium (bpV), a derivative of va...
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Pharmacologic Analgesia for Cesarean Section: An Update in 2024
With the increasing prevalence of cesarean section globally, the importance of perioperative analgesia for cesarean section is becoming increasingly evident. This article provides an overview and update on the...
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Association between sleep quality and living environment among Chinese older persons: a cross-sectional study
Sleep quality significantly affects the quality of life of older persons. Therefore, this study explored the relationship between sleep quality and living environment of older persons in China to provide a the...
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Open AccessClinical risk factors and cancer risk of thyroid imaging reporting and data system category 4 A thyroid nodules
Beyond the Thyroid Imaging Reporting and Data System (TIRADS) classification of thyroid nodules, additional factors must be weighed in the decision to perform fine needle aspiration (FNA). In this study, we ai...
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Open AccessBOLERO-5: a phase II study of everolimus and exemestane combination in Chinese post-menopausal women with ER + /HER2- advanced breast cancer
The global BOLERO-2 trial established the efficacy and safety of combination everolimus (EVE) and exemestane (EXE) in the treatment of estrogen receptor positive (ER +), HER2-, advanced breast cancer (ABC). BO...
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Open AccessSocial support, psychological capital, multidimensional job burnout, and turnover intention of primary medical staff: a path analysis drawing on conservation of resources theory
Job burnout is a prevalent and emerging challenge in the primary medical system, causing mass turnover, especially of primary medical staff. Little attention has been paid to the different dimensions of job bu...
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Open AccessEfficacy and safety of anti-PD-1/PD-L1-based dual immunotherapies versus PD-1/PD-L1 inhibitor alone in patients with advanced solid tumor: a systematic review and meta-analysis
Numerous randomized controlled trials (RCTs) have investigated PD-1/PD-L1 inhibitor-based combination therapies. The debate surrounding the potential additive clinical benefits of combination of two immune-onc...
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Open AccessProjected patterns of land uses in Africa under a warming climate
Land-use change is a direct driver of biodiversity loss, projection and future land use change often consider a topical issue in response to climate change. Yet few studies have projected land-use changes over...
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Open AccessClinical and genetic analysis of methylmalonic aciduria in 60 patients from Southern China: a single center retrospective study
Methylmalonic aciduria (MMA) is a group of rare genetic metabolic disorders resulting from defects in methylmalonyl coenzyme A mutase (MCM) or intracellular cobalamin (cbl) metabolism. MMA patients show divers...
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Open AccessAdipose tissue-derived metabolite risk scores and risk for type 2 diabetes in South Asians
South Asians are at higher risk for type 2 diabetes (T2D) than many other race/ethnic groups. Ectopic adiposity, specifically hepatic steatosis and visceral fat may partially explain this. Our objective was to...
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Open AccessAmplified positive effects on air quality, health, and renewable energy under China’s carbon neutral target
China pledged to achieve carbon neutrality by 2060 to combat global climate change, yet the resulting multi-aspect domestic impacts are not fully analysed due to an incomplete understanding of the underlying a...
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Open AccessAuthor Correction: Determining protein structures in cellular lamella at pseudo-atomic resolution by GisSPA
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Room-temperature ferrimagnetism and size-modulated electronic structures in two-dimensional cluster-based metal-organic frameworks
Cluster-assembled materials have attracted particular attention for their complex hierarchical structures and unique properties. However, the majority of cluster-based assemblies developed so far are either no...
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Open AccessCost-effectiveness uncertainty may bias the decision of coal power transitions in China
A transition away from coal power always maintains a high level of complexity as there are several overlapping considerations such as technical feasibility, economic costs, and environmental and health impacts...
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Co-benefits of transport demand reductions from compact urban development in Chinese cities
Transport is a major contributor to carbon emissions and air pollution in China. Ongoing urbanization provides a unique opportunity for Chinese cities to abate emissions by reducing transport demand via compac...