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Article
Open AccessComparison of manual and artificial intelligence-automated choroidal thickness segmentation of optical coherence tomography imaging in myopic adults
Myopia affects 1.4 billion individuals worldwide. Notably, there is increasing evidence that choroidal thickness plays an important role in myopia and risk of developing myopia-related conditions. With the adv...
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Article
Open AccessGenetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells
The A3 adenosine receptor (AR) is an important inflammatory and immunological target. However, the underlying mechanisms are not fully understood. Here, we report the gene regulation in HL-60 cells treated acutel...
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Chapter
Digital Spatial Game Development and Practice Analysis in the Home Setting
Drawing on Conceptual PlayWorld characteristics (Fleer M., Early Years 39(1):1–22, 2018, 2018), this research focused on designing digital games to support children’s spatial development in the home setting. D...
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Article
Open AccessThe PD-1- and LAG-3-targeting bispecific molecule tebotelimab in solid tumors and hematologic cancers: a phase 1 trial
Tebotelimab, a bispecific PD-1×LAG-3 DART molecule that blocks both PD-1 and LAG-3, was investigated for clinical safety and activity in a phase 1 dose-escalation and cohort-expansion clinical trial in patient...
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Article
Open AccessAlk1 acts in non-endothelial VE-cadherin+ perineurial cells to maintain nerve branching during hair homeostasis
Vascular endothelial (VE)-cadherin is a well-recognized endothelial cell marker. One of its interacting partners, the TGF-β receptor Alk1, is essential in endothelial cells for adult skin vasculature remodelin...
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Article
Open AccessNeuroLINCS Proteomics: Defining human-derived iPSC proteomes and protein signatures of pluripotency
The National Institute of Health (NIH) Library of integrated network-based cellular signatures (LINCS) program is premised on the generation of a publicly available data resource of cell-based biochemical resp...
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Article
Open AccessA multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses
The phenotype of a cell and its underlying molecular state is strongly influenced by extracellular signals, including growth factors, hormones, and extracellular matrix proteins. While these signals are normal...
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Article
Direct antiviral therapy for hepatitis C cirrhotic patients in liver transplantation settings: a systematic review
Hepatitis C (HCV)-induced decompensated cirrhosis warrants liver transplantation (LT) as the only ultimate solution. These patients experience liver deterioration, while on the transplant waitlist. However, de...
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Article
2D3D-MVPNet: Learning cross-domain feature descriptors for 2D-3D matching based on multi-view projections of point clouds
Robust local cross-domain feature descriptors of 2D images and 3D point clouds play an important role in 2D and 3D vision applications, e.g. augmented Reality (AR) and robot navigation. Essentially, the robust...
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Article
GIS-based spatial prediction of landslide using road factors and random forest for Sichuan-Tibet Highway
Accurate evaluation of landslide susceptibility is very important to ensure the safe operation of mountain highways. The Sichuan-Tibet Highway, which traverses the east of the Tibetan Plateau, frequently encou...
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Article
Open AccessAnswer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines
Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and smartphone data from over ...
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Chapter and Conference Paper
A Multi-task Learning Framework for Semantic Segmentation in MLS Point Clouds
We study a multi-task learning framework for semantic segmentation in Mobile Laser Scanning (MLS) point clouds. The existing methods on semantic segmentation of point cloud rely on a large number of annotation...
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Chapter
Best Practices in Lung Cancer Screening
This chapter reviews the best practices in lung cancer screening (LCS), including a review of the evidence base for LCS and patient selection, the benefits and harms of LCS, specialty society recommendations, ...
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Article
Open AccessSpatial evolution path of Gulangyu Island historical international community: from the perspective of actor-network theory
Gulangyu Island is a special case of social development and changes since modern China. In the past, Chinese and foreign people lived together and Chinese and Western cultures coexisted, resulting in an intern...
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Article
Open AccessMauritia flexuosa palm trees airborne mapping with deep convolutional neural network
Accurately mapping individual tree species in densely forested environments is crucial to forest inventory. When considering only RGB images, this is a challenging task for many automatic photogrammetry proces...
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Chapter
Asthma, Hay Fever, Pollen, and Climate Change
Climate change is known as one of the biggest health threats since the beginning of the twenty-first century. There has been a dramatic increase in pollen and atmospheric concentrations of greenhouse gases, in...
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Article
Open AccessAtomic-scale phase separation induced clustering of solute atoms
Dealloying typically occurs via the chemical dissolution of an alloy component through a corrosion process. In contrast, here we report an atomic-scale nonchemical dealloying process that results in the cluste...
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Article
Classification of hyperspectral images based on a convolutional neural network and spectral sensitivity
In recent years, deep learning methods have gradually come to be used in hyperspectral imaging domains. Because of the peculiarity of hyperspectral imaging, a mass of information is contained in the spectral d...
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Article
Understanding urban structures and crowd dynamics leveraging large-scale vehicle mobility data
A comprehensive understanding of city structures and urban dynamics can greatly improve the efficiency and quality of urban planning and management, while the traditional approaches of which, such as manual su...
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Article
Open AccessAntibodies to a CA 19-9 Related Antigen Complex Identify SOX9 Expressing Progenitor Cells In Human Foetal Pancreas and Pancreatic Adenocarcinoma
The Sialyl Lewis A antigen, or CA 19-9, is the prototype serum biomarker for adenocarcinoma of the pancreas. Despite extensive clinical study of CA 19-9 in gastrointestinal malignancies, surprisingly little is...