707 Result(s)
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Article
Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission
Autoimmune myocarditis (AM) is characterized by an intricate inflammatory response within the myocardium. Dynamin-related protein 1 (Drp1), a pivotal modulator of mitochondrial fission, plays a role in the pat...
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Open AccessTuft cells act as regenerative stem cells in the human intestine
In mice, intestinal tuft cells have been described as a long-lived, postmitotic cell type. Two distinct subsets have been identified: tuft-1 and tuft-2 (ref. 1). By combining analysis of primary human intestinal ...
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Open AccessDevelopment and validation of machine learning models for diagnosis and prognosis of lung adenocarcinoma, and immune infiltration analysis
The aim of our study was to develop robust diagnostic and prognostic models for lung adenocarcinoma (LUAD) using machine learning (ML) techniques, focusing on early immune infiltration. Feature selection was p...
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Open AccessDecoding Missense Variants by Incorporating Phase Separation via Machine Learning
Computational models have made significant progress in predicting the effect of protein variants. However, deciphering numerous variants of uncertain significance (VUS) located within intrinsically disordered ...
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Open AccessEZH2 mutation is associated with the development of visceral metastasis by enhancing proliferation and invasion and inhibiting apoptosis in breast cancer cells
The prognosis of breast cancer patients with visceral metastasis (VM) is significantly worse than that of patients without VM. We aimed to evaluate EZH2 (enhancer of zeste homolog 2) mutation as a biomarker as...
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Microcavity assisted graphene pressure sensor for single-vessel local blood pressure monitoring
Dynamic monitoring of blood pressure (BP) is beneficial to obtain comprehensive cardiovascular information of patients throughout the day. However, the clinical BP measurement method relies on wearing a bulky ...
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Article
Open AccessCarotid artery vascular stenosis causes the blood-CSF barrier damage and neuroinflammation
The choroid plexus (ChP) helps maintain the homeostasis of the brain by forming the blood-CSF barrier via tight junctions (TJ) at the choroid plexus epithelial cells, and subsequently preventing neuroinflammat...
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Open AccessOncological outcomes of minimally invasive surgery in non-endometrioid endometrial Cancer patients with varying prognostic risks: a retrospective cohort study based on the ESGO/ESTRO/ESP 2020 guidelines
Non-endometrioid endometrial carcinomas (NEEC) are characterized by their rarity and adverse prognoses. This study evaluates the outcomes of open versus minimally invasive surgery (MIS) in NEEC patients strati...
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Open AccessHyper-recombination in ribosomal DNA is driven by long-range resection-independent RAD51 accumulation
Ribosomal DNA (rDNA) encodes the ribosomal RNA genes and represents an intrinsically unstable genomic region. However, the underlying mechanisms and implications for genome integrity remain elusive. Here, we u...
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Article
Open AccessStructural basis for the evolution and antibody evasion of SARS-CoV-2 BA.2.86 and JN.1 subvariants
The Omicron subvariants of SARS-CoV-2, especially for BA.2.86 and JN.1, have rapidly spread across multiple countries, posing a significant threat in the ongoing COVID-19 pandemic. Distinguished by 34 addition...
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Article
The Footprints of Mitochondrial Fission and Apoptosis in Fluoride-Induced Renal Dysfunction
Fluoride (F) is widely distributed in the environment and poses serious health risks to humans and animals. Although a good body of literature demonstrates a close relationship between F content and renal syst...
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Open AccessSuperior detection of low-allele burden Janus kinase 2 V617F mutation and monitoring clonal evolution in myeloproliferative neoplasms using chip-based digital PCR
The JAK2 V617F is a prevalent driver mutation in Philadelphia chromosome-negative myeloproliferative neoplasms (Ph−MPNs), significantly affecting disease progression, immunophenotype, and patient outcomes. The Wo...
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Article
Open AccessmTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancer
Cyclic GMP–AMP synthase (cGAS), a cytosolic DNA sensor that initiates a STING-dependent innate immune response, binds tightly to chromatin, where its catalytic activity is inhibited; however, mechanisms underl...
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Open AccessPasteurella multocida infection induces blood–brain barrier disruption by decreasing tight junctions and adherens junctions between neighbored brain microvascular endothelial cells
Meningitis induced by Pasteurella multocida has been substantially described in clinical practice in both human and veterinary medicine, but the underlying mechanisms have not been previously reported. In this st...
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Article
The relationship between sleep quality and suicidal ideation in college students: the longitudinal mediating role of negative affect and the neural basis of this relationship
Studies have shown that sleep quality is a critical predictor of suicidal ideation. However, the mechanisms by which sleep quality affects suicidal ideation remain largely unknown. We aimed to examine the long...
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Article
Superhydrophobic melamine sponge prepared by radiation-induced grafting technology for efficient oil–water separation
This paper presents a superhydrophobic melamine (ME) sponge (ME-g-PLMA) prepared via high-energy radiation-induced in situ covalent grafting of long-alkyl-chain dodecyl methacrylate (LMA) onto an ME sponge for...
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Article
Open AccessUltrasound-responsive theranostic platform for the timely monitoring and efficient thrombolysis in thrombi of tPA resistance
There is no effective and noninvasive solution for thrombolysis because the mechanism by which certain thrombi become tissue plasminogen activator (tPA)-resistant remains obscure. Endovascular thrombectomy is ...
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Article
Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses
Increasing evidence implicates the tumor microbiota as a factor that can influence cancer progression. In patients with colorectal cancer (CRC), we found that pre-resection antibiotics targeting anaerobic bact...
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Storm Liquefaction Deposits: A Possibility of Time Reversal in Sedimentary Strata of an Estuarial Coastal Area
In the sedimentary strata dating of estuarial coastal areas, it is often found that there is phenomenon of time-reversal in strata. The seabed sediments could be liquefied under storm waves. A laboratory wave ...
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Electro-driven cycling Fenton catalysis through two-dimensional electroresponsive metal–organic frameworks for water purification
The electro-Fenton process is a promising technology for eliminating emerging organic pollutants from water. However, its potential is hindered by the lack of cathode materials with the essential cycling catal...