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Article
Open Accessi-CRISPR: a personalized cancer therapy strategy through cutting cancer-specific mutations
Developing a strategy to specifically kill cancer cells without inducing obvious damage to normal cells may be of great clinical significance for cancer treatment. In the present study, we developed a new prec...
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Article
Open AccessOptimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge
Cas9 RNA functions as a miRNA sponge.
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Article
Treat-to-target strategies aiming at additional ultrasound remission is associated with better control of disease activity and less flare in rheumatoid arthritis
Treat-to-target (T2T) strategy has greatly improved the prognosis of rheumatoid arthritis (RA). However, the additional benefit of targeting ultrasound (US) remission in addition to clinical remission has been...
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Chapter and Conference Paper
BOUNCE: An Efficient Selective Enumeration Approach for Nested Named Entity Recognition
The scenario that one entity contains other entities is known as nested entities. Nested named entity recognition is a fundamental and challenging task in various NLP applications. The state-of-the-art nested ...
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Article
Open AccessThe agreement between ultrasound-determined joint inflammation and clinical signs in patients with rheumatoid arthritis
Ultrasound (US) is sensitive for detecting joint and tendon inflammation in patients with rheumatoid arthritis (RA). So far, which grade of abnormalities on US corresponds to clinical manifestations is unclear...
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Article
Open AccessExploitation of heterosis loci for yield and yield components in rice using chromosome segment substitution lines
We constructed 128 chromosome segment substitution lines (CSSLs), derived from a cross between indica rice (Oryza sativa L.) 9311 and japonica rice Nipponbare, to investigate the genetic mechanism of heterosis. T...