-
Article
Open AccessNRP1 interacts with endoglin and VEGFR2 to modulate VEGF signaling and endothelial cell sprouting
Endothelial cells express neuropilin 1 (NRP1), endoglin (ENG) and vascular endothelial growth factor receptor 2 (VEGFR2), which regulate VEGF-A-mediated vascular development and angiogenesis. However, the link...
-
Article
Ultrasound radiomics-based nomogram to predict lymphovascular invasion in invasive breast cancer: a multicenter, retrospective study
To develop and validate an ultrasound (US) radiomics-based nomogram for the preoperative prediction of the lymphovascular invasion (LVI) status in patients with invasive breast cancer (IBC).
-
Article
Enhanced adsorption and visible-light photocatalysis on TiO2 with in situ formed carbon quantum dots
Carbon quantum dots (CQDs) can be used to modify TiO2 to extend the light absorption threshold and enhance its photocatalytic efficiency. In this study, different amounts of CQDs modified TiO2 (CQDs-x/TiO2) were ...
-
Article
Open AccessDevelopment of whole-cell catalyst system for sulfide biotreatment based on the engineered haloalkaliphilic bacterium
Microorganisms play an essential role in sulfide removal. Alkaline absorption solution facilitates the sulfide’s dissolution and oxidative degradation, so haloalkaliphile is a prospective source for environmen...
-
Article
Open AccessINPP4B protects from metabolic syndrome and associated disorders
A high fat diet and obesity have been linked to the development of metabolic dysfunction and the promotion of multiple cancers. The causative cellular signals are multifactorial and not yet completely understo...
-
Article
Open AccessAndrogen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells
There is mounting evidence of androgen receptor signaling inducing genome instability and changing DNA repair capacity in prostate cancer cells. Expression of genes associated with base excision repair (BER) i...
-
Article
Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity
Activation and transcriptional reprogramming of AR in advanced prostate cancer frequently coincides with the loss of two tumor suppressors, INPP4B and PTEN, which are highly expressed in human and mouse prosta...
-
Protocol
Techniques for Evaluation of AR Transcriptional Output and Recruitment to DNA
Steroid receptors are ligand activated transcription factors whose promoter specificity is regulated by a broad set of coregulators and pioneer factors. Corepressors and coactivators determine receptors’ recru...
-
Article
Steroidal Glycosides from the Fruits of Tribulus terrestris
Four new steroidal saponins were isolated from the fruits of Tribulus terrestris. Their structures were established by spectroscopic and chemical analysis as (25R)-26-O-β-D-glucopyranosyl-5α-furost-3β,22α,26- ...