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Article
Open AccessMembrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition
The Bin/Amphiphysin/Rvs (BAR) domain protein FAM92A1 is a multifunctional protein engaged in regulating mitochondrial ultrastructure and ciliogenesis, but its physiological role in the brain remains unclear. H...
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Article
Open AccessPolymer Fiber Rigid Network with High Glass Transition Temperature Reinforces Stability of Organic Photovoltaics
A unique approach is proposed: constructing a polymer fiber rigid network with high glass transition temperature.
Frozen bul...
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Article
Open AccessAuthor Correction: An all-in-one tetrazine reagent for cysteine-selective labeling and bioorthogonal activable prodrug construction
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Article
Open AccessAn all-in-one tetrazine reagent for cysteine-selective labeling and bioorthogonal activable prodrug construction
The prodrug design strategy offers a potent solution for improving therapeutic index and expanding drug targets. However, current prodrug activation designs are mainly responsive to endogenous stimuli, resulti...
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Chapter and Conference Paper
Research on Piano Harmony Automatic Orchestration System Based on Deep Learning
The research of piano harmony auto orchestrator system based on deep learning is to create a method to automatically create music scores from the original data of piano music. The original data includes not on...
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Article
Open AccessIntranasal mask for protecting the respiratory tract against viral aerosols
The spread of many infectious diseases relies on aerosol transmission to the respiratory tract. Here we design an intranasal mask comprising a positively-charged thermosensitive hydrogel and cell-derived micro...
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Article
Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization
The COVID-19 pandemic has fostered major advances in vaccination technologies1–4; however, there are urgent needs for vaccines that induce mucosal immune responses and for single-dose, non-invasive administration
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Article
Open AccessVisualizing the spatial distribution of inflammation in the depressed brain with a targeted MRI nanoprobe in vivo
Depression is a prevalent mental illness that imposes a substantial public health burden. However, the diverse clinical phenotypes observed in patients make it difficult to realize precise diagnosis. Recently,...
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Article
Reducing CO2 emissions from the rebalancing operation of the bike-sharing system in Beijing
With the development of the bike-sharing system (BSS) and the introduction of green and low carbon development, the environmental impacts of BSS had received increasing attention in recent years. However, the ...
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Article
Open AccessStrong, tough, rapid-recovery, and fatigue-resistant hydrogels made of picot peptide fibres
Hydrogels are promising soft materials as tissue engineering scaffolds, stretchable sensors, and soft robotics. Yet, it remains challenging to develop synthetic hydrogels with mechanical stability and durabili...
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Article
Emotive Tonality of the "Youth–Old Age" Dichotomy in Russian and Chinese Media Discourses: The Stage of Psychosemantic Expertise
The issue of attitude to age has the character of social stigma at different stages of human civilization, therefore, the identification of the general and particular in the assessments of the "youth–old age" ...
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Article
Open AccessDNA methylation abnormalities induced by advanced maternal age in villi prime a high-risk state for spontaneous abortion
Advanced maternal age (AMA) has increased in many high-income countries in recent decades. AMA is generally associated with a higher risk of various pregnancy complications, and the underlying molecular mechan...
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Article
Open AccessBrain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys
Integrative analyses of transcriptomic and neuroimaging data have generated a wealth of information about biological pathways underlying regional variability in imaging-derived brain phenotypes in humans, but ...
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Article
The genesis of granite mass in the volcanic area of Litang, Chuanxi province: constraints from rock geochemistry and U–Pb zircon dating
The granite complex in the Maohuo area of Litang County is located in the central and western parts of the Yidun-Shaluri island arc in the Sanjiang area; the intrusion is located in the sand slate of the Tumug...
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Article
Open AccessDual-stimuli responsive smart nanoprobe for precise diagnosis and synergistic multi-modalities therapy of superficial squamous cell carcinoma
Although the promising advancements of current therapeutic approaches is available for the squamous cell carcinoma (SCC) patients, the clinical treatment of SCC still faces many difficulties. The surgical irre...
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Article
Open AccessIdentification and characterization of a novel cell binding and cross-reactive region on spike protein of SARS-CoV-2
Given that COVID-19 continues to wreak havoc around the world, it is imperative to search for a conserved region involved in viral infection so that effective vaccines can be developed to prevent the virus fro...
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Article
Economic policy uncertainty, investor sentiment and financial stability—an empirical study based on the time varying parameter-vector autoregression model
This paper applies the time varying parameter-vector autoregression model to explore the dynamic relationship between economic policy uncertainty, investor sentiment and financial stability in China in differe...
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Article
Open AccessTertiary lymphoid structures are associated with favorable survival outcomes in patients with endometrial cancer
Immunotherapy has experienced remarkable growth recently. Tertiary lymphoid structures (TLSs) and B cells may play a key role in the immune response and have a survival benefit in some solid tumors, but there ...
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Chapter and Conference Paper
Integrated Information Sharing Platform for University Students Based on Data Mining Technology
Through the campus data sharing platform to realize the data sharing of various business systems in universities, so as to provide a comprehensive and accurate data foundation for the school to realize all-rou...
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Article
Open AccessHydrogel tapes for fault-tolerant strong wet adhesion
Fast and strong bio-adhesives are in high demand for many biomedical applications, including closing wounds in surgeries, fixing implantable devices, and haemostasis. However, most strong bio-adhesives rely on...