118 Result(s)
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Open AccessThe new advance of exosome-based liquid biopsy for cancer diagnosis
Liquid biopsy is a minimally invasive method that uses biofluid samples instead of tissue samples for cancer diagnosis. Exosomes are small extracellular vesicles secreted by donor cells and act as mediators of...
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Aerosol in the subarctic region impacts on Atlantic meridional overturning circulation under global warming
The Atlantic Meridional Overturning Circulation (AMOC) is a crucial system influencing regional and even global climate changes, with the Subpolar North Atlantic (SPNA) being a key region affecting this system...
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Open AccessExosomal miR-4745-5p/3911 from N2-polarized tumor-associated neutrophils promotes gastric cancer metastasis by regulating SLIT2
Tumor cells remodel the phenotype and function of tumor microenvironment (TME) cells to favor tumor progression. Previous studies have shown that neutrophils in TME are polarized to N2 tumor-associated neutrop...
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Open AccessA cross-sectional study of optimal exercise combinations for type 2 diabetes
The currently recommended exercise methods for patients with diabetes require strict physical fitness and are not suitable for all diabetic patients. This study aims to explore the best exercise combination fo...
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Open AccessAssessment of Arctic sea ice simulations in cGENIE model and projections under RCP scenarios
Simulating and predicting Arctic sea ice accurately remains an academic focus due to the complex and unclear mechanisms of Arctic sea ice variability and model biases. Meanwhile, the relevant forecasting and m...
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Open AccessAssociation Between Myopia and Pupil Diameter in Preschoolers: Evidence from a Machine Learning Approach Based on a Real-World Large-Scale Dataset
Previous studies have explored the connections between various ocular biological parameters with myopia. Our previous study also found that pupil data can predict the myopic progression during the intervention...
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Open AccessOptimal ICSI timing on immature oocytes for low prognosis patients under the POSEIDON classification
The optimal timing of performing ICSI on immature oocytes for POSEIDON patients is still unknown to get better early embryonic development outcomes. The purpose of this study was to implore the most appropriat...
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Salivary iodine concentration in pregnant women and its association with iodine status and thyroid function
There have been no reports on the application of salivary iodine concentration (SIC) in evaluating iodine nutrition in pregnant women. This study aimed to clarify the relationship between SIC and indicators of...
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Open AccessRole of the sigma factor AlgU in regulating growth, virulence, motility, exopolysaccharide production, and environmental stress adaptation of Pseudomonas syringae pv. actinidiae QSY6
The extracytoplasmic function (ECF) sigma factor AlgU is involved in the regulation of various virulence-related pathways in Pseudomonas syringae, especially alginate biosynthesis and motility, and the role of Al...
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Open AccessComparative genomic analyses provide insight into the pathogenicity of three Pseudomonas syringae pv. actinidiae strains from Anhui Province, China
Pseudomonas syringae pv. actinidiae (Psa) is an important bacterial plant pathogen that causes severe damage to the kiwifruit industry worldwide. Three Psa strains were recently obtained from different kiwifruit ...
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Correction: Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer
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Visual impairment burden in retinopathy of prematurity: trends, inequalities, and improvement gaps
Retinopathy of prematurity (ROP) is an important cause of avoidable childhood visual impairment, and the increase in number and survival of premature infants may inflate its burden globally. We aimed to compre...
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Intermittent fasting shifts the diurnal transcriptome atlas of transcription factors
Intermittent fasting remains a safe and effective strategy to ameliorate various age-related diseases, but its specific mechanisms are not fully understood. Considering that transcription factors (TFs) determi...
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Open AccessAssociation between body stature with ocular biometrics and refraction among Chinese preschoolers
To evaluate the association of body stature with ocular biometrics and refraction in preschool children.
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Mechanism of multi-organ compensation under different iodine intake in pregnant rats: results from a repeated-measures study of iodine metabolism
This study aimed to explore the differences in iodine metabolism and expression of NIS and Pendrin in pregnant rats under different iodine nutritional status.
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Open AccessSingle-cell RNA sequencing reveals roles of unique retinal microglia types in early diabetic retinopathy
The pathophysiological mechanisms of diabetic retinopathy (DR), a blinding disease, are intricate. DR was thought to be a microvascular disease previously. However, growing studies have indicated that the reti...
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Open AccessCuprotosis clusters predict prognosis and immunotherapy response in low-grade glioma
Cuprotosis, an emerging mode of cell death, has recently caught the attention of researchers worldwide. However, its impact on low-grade glioma (LGG) patients has not been fully explored. To gain a deeper insi...
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Comparison of clinical effectiveness of conbercept and ranibizumab for treating retinopathy of prematurity: a meta-analysis
Conbercept and ranibizumab have been used to treat retinopathy of prematurity (ROP). However, the clinical effectiveness of conbercept and ranibizumab remains controversial.
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Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer
Peritoneal metastasis (PM) is an important factor contributing to poor prognosis in patients with gastric cancer (GC). Transcriptomic sequencing has been used to explore the molecular changes in metastatic can...
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Open AccessAutologous non-invasively derived stem cells mitochondria transfer shows therapeutic advantages in human embryo quality rescue
The decline in the quantity and quality of mitochondria are closely associated with infertility, particularly in advanced maternal age. Transferring autologous mitochondria into the oocytes of infertile female...