797 Result(s)
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Article
Open AccessChromosome-level genome assembly of the cashmere goat
The goat, an early domesticated ruminant, is a reliable source of cashmere, meat and milk in global agricultural production. Despite this, the genome of cashmere-rich goats has yet to be characterized. Here, w...
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Open AccessCrop stress detection from UAVs: best practices and lessons learned for exploiting sensor synergies
Detecting and monitoring crop stress is crucial for ensuring sufficient and sustainable crop production. Recent advancements in unoccupied aerial vehicle (UAV) technology provide a promising approach to map ke...
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Article
Tauroursodeoxycholic acid targets HSP90 to promote protein homeostasis and extends healthy lifespan
As the elderly population expands, the pursuit of therapeutics to reduce morbidity and extend lifespan has become increasingly crucial. As an FDA-approved drug for chronic cholestatic liver diseases, taurourso...
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Anisotropic coherence induced nonuniform amplification in N 2 +
The continuous progress in N 2 + lasing recently stimulates a great deal of interest in nonlinear and quantum optics of molecular ions, while a complete description ...
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Article
Open AccessThe temporal and spatial interpretation of China’s health financing: what do Chinese’ government ‘do’ in new healthcare reform?
The analysis of health expenditure and its structure takes on a critical significance in national health policy research, and the public welfare of national health undertakings can be manifested by the governm...
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Improving the Retention Rate of Fat Grafting by Botulinum Toxin A: A Randomized, Self-controlled, Clinical Trial
Botulinum toxin A (BTX-A) can enhance the efficacy of fat grafting. However, most studies conducted animal experiments, lacked objective clinical data, or were non-randomized controlled trials. Thus, objective...
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Article
The hidden influence: how self-concealment shapes the effect of trauma centrality on PTSD symptoms and posttraumatic growth
Although trauma centrality was positively associated with posttraumatic stress disorder (PTSD) and posttraumatic growth (PTG), few studies have examined the factors that may influence the strength of these ass...
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DFT study of defective h-BAs: effective adsorption for radioactive gaseous iodine
The adsorption behavior of iodine molecules on hexagonal boron arsenide (h-BAs), both pristine and defective, has been systematically investigated using first-principles. The maximum adsorption energy of I2 on pr...
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Article
Open AccessA novel M2-like tumor associated macrophages-related gene signature for predicting the prognosis and immunotherapy efficacy in gastric cancer
M2-like tumor-associated macrophages (M2-like TAMs) play key roles in tumor progression and the immune response. However, the clinical significance and prognostic value of M2-like TAMs-associated regulatory ge...
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Immunometabolic profiling related with gestational diabetes mellitus: a nested case-control study of CD4+ T cell phenotypes and glycemic traits
To investigate immunometabolic associations of CD4+ T cell phenotypes with gestational diabetes mellitus (GDM).
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Decoding the fish genome opens a new era in important trait research and molecular breeding in China
Aquaculture represents the fastest-growing global food production sector, as it has become an essential component of the global food supply. China has the world’s largest aquaculture industry in terms of produ...
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Open AccessAssociation between weight change and serum anti-aging protein α-Klotho: a cross-sectional study in middle-aged and older adults
The relationship of weight change has extended to accelerated ageing, yet little is known about the association between weight change and anti-aging protein α-Klotho. This study included 10,972 subjects from t...
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The impact of homocysteine on patients with diabetic nephropathy: a mendelian randomization study
Homocysteine (Hcy) has been associated with an increased risk of diabetic nephropathy (DN) in patients, but there is still controversy. This study aims to investigate the causal relationship between plasma Hcy...
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Microstructure and room temperature fracture toughness of Nb–Si-based alloys with Sr addition
Nb–Si-based alloys show great potential to surpass the widely used Ni-based superalloys. The element Sr is widely applied in aluminum and magnesium alloys, but reports about the effects of Sr on Nb–Si-based al...
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Cysteine Catalyzed Pictet-Spengler Reaction: a Convenient and Mild Method for Synthesis of Spiroindolones
Pictet-Spengler reaction is one of the main ways to synthesize spiroindolones, which widely exists in natural products and pharmaceutical agents. We accidentally discovered bovine serum albumin (BSA) had catal...
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Article
Multi-component Crystal Strategy for Improving Water Solubility and Antifungal Activity of Climbazole
The primary problem with climbazole (CLB), a broad-spectrum imidazole antifungal drug, is its low water solubility. In order to increase its water solubility and antifungal activity, three new multi-component ...
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Article
Family doctors signing service in Dongguan City: what is important factors of family doctors performance?
To explore the influencing factors of family doctors agreement performance rate in Dongguan City, Guangdong Province.
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Article
Molecular design of hydroxamic acid-based derivatives as urease inhibitors of Helicobacter pylori
Helicobacter pylori is the main causative agent of gastric cancer, especially non-cardiac gastric cancers. This bacterium relies on urease producing much ammonia to colonize the host. Herein, the study provides v...
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Efficacy of programmed cell death 1 inhibitor maintenance after chimeric antigen receptor T cells in patients with relapsed/refractory B-cell non-Hodgkin-lymphoma
Chimeric antigen receptor (CAR)-T cells obtained long-term durability in about 30% to 40% of relapsed/refractory (r/r) B-cell non-Hodgkin lymphoma (B-NHL). Maintenance therapy after CAR-T is necessary, and PD1...
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Risk Factors and Predictive Nomogram for Survival in Elderly Patients with Brain Glioma
To determine the factors that contribute to the survival of elderly individuals diagnosed with brain glioma and develop a prognostic nomogram.