1,852 Result(s)
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EVA1A reverses lenvatinib resistance in hepatocellular carcinoma through regulating PI3K/AKT/p53 signaling axis
Lenvatinib is a commonly used first-line drug for the treatment of advanced hepatocellular carcinoma (HCC). However, its clinical efficacy is limited due to the drug resistance. EVA1A was a newly identified tu...
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Open AccessOxaliplatin-induced upregulation of exosomal miR-424-3p derived from human bone marrow mesenchymal stem cells attenuates progression of gastric cancer cells
Chemotherapy, particularly with oxaliplatin, is a key treatment for advanced gastric cancer (GC), and exosomes derived from human bone marrow mesenchymal stem cells (hBM-MSCs) play a vital role in the tumor mi...
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Clinical application potential of large language model: a study based on thyroid nodules
Limited data indicated the performance of large language model (LLM) taking on the role of doctors. We aimed to investigate the potential for ChatGPT-3.5 and New Bing Chat acting as doctors using thyroid nodul...
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Open AccessTrends in the antimicrobial susceptibility among Chinese neonates from 2012 to 2021: a multicenter study
Antibiotic resistance is a serious global public health issue. However, there are few reports on trends in antimicrobial susceptibility in Chinese neonates, and most of the existing evidence has been derived f...
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A soft gripper driven by conical dielectric elastomer actuator to achieve displacement amplification and compliant grips
Flexible dielectric elastomeric actuators (DEAs) have become significant in soft robots with intelligent systems. They overcome the shortcomings of traditional rigid systems, thereby expanding their applicatio...
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Open AccessEffect of force direction and impaction angulation during dilaceration impacted central incisor traction: a finite element analysis
The effects of traction forces at different angles on impacted central incisors(ICI)with varying inverted angles (IA) may be different. The objective of this study was to analyze the biomechanical effects of d...
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Open AccessTransplantation of human endometrial perivascular stem cells with hydroxy saffron yellow A promotes uterine repair in rats
Intrauterine adhesions (IUAs) jeopardise uterine function in women, which is a great challenge in the clinic. Previous studies have shown that endometrial perivascular cells (En-PSCs) can improve the healing o...
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Efficacy and safety of dual renin–angiotensin system (RAS) blockade for non-elderly diabetic kidney disease patients with preserved eGFR
Although sodium glucose cotransporter2 inhibitor (SGLT-2I) is widely used in clinical practice, sufficient renin–angiotensin system (RAS) inhibition remains the cornerstone of diabetic kidney disease (DKD) tre...
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Open AccessHMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage
Drug-induced organic damage encompasses various intricate mechanisms, wherein HMGB1, a non-histone chromosome-binding protein, assumes a significant role as a pivotal hub gene. The regulatory functions of HMGB...
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Open AccessDoes bilateral Wilms’ tumor involving the collecting system in children have a worse prognosis?
The literature on nephron-sparing surgery (NSS) in children with bilateral Wilms’ tumors (BWT) involving the collection system is mostly comprised of case reports. The present study aimed to summarize the clin...
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Open AccessSelective anti-tumor activity of glutathione-responsive abasic site trapping agent in anaplastic thyroid carcinoma
Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive thyroid cancer with poor prognosis. Killing cancer cells by inducing DNA damage or blockage of DNA repair is a promising strategy for chemothe...
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Open AccessEvaluating three internal fixation techniques for Pauwels III femoral neck fractures via finite element analysis
The selection of implants for fixing unstable femoral neck fractures (FNF) remains contentious. This study employs finite element analysis to examine the biomechanics of treating Pauwels type III femoral neck ...
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Open AccessEstablishment and characterization of a novel multidrug-resistant pancreatic ductal adenocarcinoma cell line, PDAC-X1
Drug resistance remains a significant challenge in the treatment of pancreatic cancer. The development of drug-resistant cell lines is crucial to understanding the underlying mechanisms of resistance and devel...
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Open AccessCorrection: Sorcin regulate pyroptosis by interacting with NLRP3 inflammasomes to facilitate the progression of hepatocellular carcinoma
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Open AccessSinus rhythm restoration reverses tricuspid regurgitation in patients with atrial fibrillation: a systematic review and meta-analysis
Tricuspid regurgitation (TR) is a common valvular heart disease worldwide, and current guidelines for TR treatment are relatively conservative, as well as with detrimental outcomes. Restoration of sinus rhythm...
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Open AccessA retrospective study of adjuvant albumin-bound paclitaxel plus S-1 after D2 gastrectomy versus oxaliplatin plus S-1 in gastric cancer
Adjuvant oxaliplatin plus S-1 (SOX) chemotherapy for gastric cancer (GC) after D2 gastrectomy has been proven effective. There has yet to be a study that evaluates adjuvant nanoparticle albumin-bound paclitaxe...
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Retraction Note: Do the academician independent directors promote green innovation in enterprises?
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Constantly optimized mean teacher for semi-supervised 3D MRI image segmentation
The mean teacher model and its variants, as important methods in semi-supervised learning, have demonstrated promising performance in magnetic resonance imaging (MRI) data segmentation. However, the superior p...
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Three-dimensional motion vector translation for geometric partitioning mode in panoramic video coding using H.266/VVC
Geometric partitioning mode (GPM) is introduced into H.266/versatile video coding (VVC) as a new inter-frame prediction technology, in which one block can be divided into two non-rectangular blocks to increase...
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Bracket-type Vertical Load Transfer System for Heavy-load Column Strengthening: Design and Application
In the column strengthening under the beam support, for the columns with large section size, heavy load, and defects, a new type of load transfer system (LTS) was proposed: the bracket-type vertical load trans...