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Article
Inhibition of immunoglobulin E attenuates pulmonary hypertension
Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by pulmonary vascular remodeling. Immunoglobulin E (IgE) is known to participate in aortic vascular remodeling, but whether IgE med...
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Article
P-Selectin Glycoprotein Ligand-1 Deficiency Protects Against Aortic Aneurysm Formation Induced by DOCA Plus Salt
P-selectin glycoprotein ligand-1 (PSGL-1) acts as a crucial regulator for the inflammatory cells infiltration by mediating the adhesion of leukocytes. However, the role of PSGL-1 in aortic aneurysm remains elu...
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Article
Open AccessNovel LTBP3 mutations associated with thoracic aortic aneurysms and dissections
Thoracic aortic aneurysm and dissection (TAAD) is a hidden-onset but life-threatening disorder with high clinical variability and genetic heterogeneity. In recent years, an increasing number of genes have been...
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Article
An interpretation of water recharge in karst trough zone as determined by high-resolution tracer experiments in western Hubei, China
To investigate the hydrogeological characteristics of the karst trough zone in China, two groundwater systems (Yuquandong [YQD] and Migongquan [MGQ]) in Sixi Valley, western Hubei, were discussed. Seven groups...
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Article
Open AccessClinical characteristics and survival of Chinese patients diagnosed with pulmonary arterial hypertension who carry BMPR2 or EIF2KAK4 variants
Variants in the gene encoding bone morphogenetic protein receptor type II (BMPR2) are the most common genetic cause of pulmonary arterial hypertension (PAH), whereas biallelic variants in the eukaryotic translati...
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Article
Open AccessReversible splenial lesion syndrome (RESLES) due to acute intermittent porphyria with a novel mutation in the hydroxymethylbilane synthase gene
Reversible splenial lesion syndrome (RESLES) is a clinico-radiological syndrome characterized by the presence of reversible lesions specifically involving the splenium of the corpus callosum (SCC). The cause o...
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Article
Open AccessExosomal miR-423-5p mediates the proangiogenic activity of human adipose-derived stem cells by targeting Sufu
Human adipose-derived stem cells (hADSCs) are an important source of cells for regenerative medicine. Evidence of extensive interactions with the surrounding microenvironment has led researchers to focus more ...
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Article
Open AccessGenetic analyses in a cohort of 191 pulmonary arterial hypertension patients
Pulmonary arterial hypertension (PAH) is a progressive and fatal disorder associated with high pulmonary artery pressure. Genetic testing enables early diagnosis and offers an opportunity for family screening....