539 Result(s)
-
Article
Retraction Note: Near Infrared Light-Actuated PEG Wrapping Carbon Nanodots Loaded Cisplatin for Targeted Therapy of Lung Cancer Therapy
-
Article
Open AccessLight-gated integrator for highlighting kinase activity in living cells
Protein kinases are key signaling nodes that regulate fundamental biological and disease processes. Illuminating kinase signaling from multiple angles can provide deeper insights into disease mechanisms and im...
-
Article
Open AccessStudy on the influencing factors of imbibition in tight reservoirs based on molecular dynamics simulation
Nanopores are in dominant positions in tight reservoirs. Recently, global scholars have focused on the role of imbibition in tight reservoirs on the macroscale, which is insufficient for understanding the proc...
-
Article
Characteristics of tandem repeat inheritance and sympathetic nerve involvement in GAA-FGF14 ataxia
Intronic GAA repeat expansion ([GAA] ≥250) in FGF14 is associated with the late-onset neurodegenerative disorder, spinocerebellar ataxia 27B (SCA27B, GAA-FGF14 ataxia). We aim to determine the prevalence of the G...
-
Article
Investigation of infections status in pediatric patients with acute myeloid leukemia during the induction period–a retrospective study in two medical centers
This study aims to investigate the clinical characteristics of infections following induction chemotherapy for acute myeloid leukemia (AML) in children and identify risk factors associated with severe infectio...
-
Article
Open AccessHealth information literacy among children with spinal muscular atrophy and their caregivers
Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease that leads to multiple organ dysfunction. The advent of disease-modifying treatments makes the early diagnosis of SMA critical. Heal...
-
Article
Effects of Different Nitrogen Fertilizer Rates on Soil Magnesium Leaching in Tea Garden
Magnesium (Mg) helps improve tea yield and quality, yet many tea plantations in China commonly exhibit magnesium deficiency. Therefore, studying the mechanisms of Mg2+ leaching in tea plantation soils is of signi...
-
Article
Open AccessLinking morphology, genome, and metabolic activity of uncultured magnetotactic Nitrospirota at the single-cell level
Magnetotactic bacteria (MTB) are a unique group of microorganisms that sense and navigate through the geomagnetic field by biomineralizing magnetic nanoparticles. MTB from the phylum Nitrospirota (previously k...
-
Article
Open AccessEffect of dietary antioxidant quality score on tobacco smoke exposure and asthma in children and adolescents: a cross-sectional study from the NHANES database
Asthma is a common non-communicable disease in children, and airway inflammation is the main pathological change of asthma. Tobacco smoke exposure (TSE) can cause systematic inflammation and oxidative stress, ...
-
Article
Developing a modified textbook outcome for elderly patients with gastric cancer: a multi-center study
Textbook outcome (TO) is widely recognized as a comprehensive prognostic indication for patients with gastric cancer (GC). This study aims to develop a modified TO (mTO) for elderly patients with GC.
-
Article
Open AccessExploring the relationship between gut microbiota and breast cancer risk in European and East Asian populations using Mendelian randomization
Several studies have explored the potential link between gut microbiota and breast cancer; nevertheless, the causal relationship between gut microbiota and breast cancer remains unclear.
-
Article
Open AccessResearch on the rapid tissue breeding technology of the endangered plant Cibotium barometz (L.) J. Sm.
Cibotium barometz (L.) J. Sm., a fern, holds significant value in traditional Chinese medicine. This research aimed to establish a rapid tissue breeding technology for Cibotium barometz (L.) and provide a theoret...
-
Article
Transcranial Alternating Current Stimulation in a Patient with Ataxia-Ocular Apraxia 2: a Case Report
Ataxia-ocular apraxia 2 (AOA2) is a rare neurodegenerative autosomal recessive disorder with no effective treatment. In this study, we present the case of a patient diagnosed with AOA2, who experienced walking...
-
Article
A transformer-based weakly supervised computational pathology method for clinical-grade diagnosis and molecular marker discovery of gliomas
The complex diagnostic criteria for gliomas pose great challenges for making accurate diagnoses with computational pathology methods. There are no in-depth analyses of the accuracy, reliability and auxiliary c...
-
Article
Open AccessCorrection to: Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism
-
Article
Mixing with Schima Superba Enhanced Soil Fertility and Simplified Soil Microbial Community of Eucalyptus Urophylla Forests
This study focuses on how the native broad-leaved tree species, Schima superba (Ss), influence the belowground ecological environment of the long-time pure Eucalyptus culture plantations (PCP) in South China. We ...
-
Article
Open AccessDiagnostic accuracy of low-dose dual-input computed tomography perfusion in the differential diagnosis of pulmonary benign and malignant ground-glass nodules
This study aimed to evaluate the value of low-dose dual-input computed tomography perfusion (CTP) imaging in the differential diagnosis of benign and malignant pulmonary ground-glass opacity nodules (GGO). A r...
-
Article
Open AccessPromoting reactive oxygen species accumulation to overcome tyrosine kinase inhibitor resistance in cancer
In tumor treatment, protein tyrosine kinase inhibitors (TKIs) have been extensively utilized. However, the efficacy of TKI is significantly compromised by drug resistance. Consequently, finding an effective so...
-
Article
Open AccessA positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression
The aberrant expression of phosphofructokinase-platelet (PFKP) plays a crucial role in the development of various human cancers by modifying diverse biological functions. However, the precise molecular mechani...
-
Article
Open AccessProtein SUMOylation promotes cAMP-independent EPAC1 activation
Protein SUMOylation is a prevalent stress-response posttranslational modification crucial for maintaining cellular homeostasis. Herein, we report that protein SUMOylation modulates cellular signaling mediated ...