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Open AccessCorrection: Anti-CD5 CAR-T cells with a tEGFR safety switch exhibit potent toxicity control
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Bioaccumulation mediated by water solubility leads to differences in the acute toxicity of organophosphorus insecticides to zebrafish (Danio rerio)
The use of some organophosphate insecticides is restricted or even banned in paddy fields due to their high toxicity to aquatic organisms. The aim of this study is to elucidate the main pathways and target org...
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Article
Preference detection of the humanoid robot face based on EEG and eye movement
The face of a humanoid robot can affect the user experience, and the detection of face preference is particularly important. Preference detection belongs to a branch of emotion recognition that has received mu...
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Open AccessAnti-CD5 CAR-T cells with a tEGFR safety switch exhibit potent toxicity control
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Rethinking the Encoder–decoder Structure in Medical Image Segmentation from Releasing Decoder Structure
Medical image segmentation has witnessed rapid advancements with the emergence of encoder–decoder based methods. In the encoder–decoder structure, the primary goal of the decoding phase is not only to restore ...
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A decoder-free feature aggregation network for medical image segmentation
Encoder-decoder structured networks have recently become dominant in medical image segmentation, primarily due to their straightforward architecture. However, their extensive use of up-sampling operations, aim...
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Methods for Analysis of Extracellular Vesicle Functions
Extracellular vesicles (EVs) are nanoscale vesicles that are secreted by virtually all cells and are involved in numerous biological processes. Studies of EV function have necessitated the development of vario...
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Residue dissipation dynamics and dietary risk assessment of emamectin benzoate, chlorantraniliprole, chlorfenapyr, and lufenuron in cabbage
Emamectin benzoate (EB), chlorantraniliprole (CTP), chlorfenapyr (CFP), and lufenuron (LFR) are widely used to control Spodoptera exigua on cabbage. This study is aimed at establishing a universal, sensitive, acc...
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Open AccessA novel tumor purity and immune infiltration-related model for predicting distant metastasis-free survival in prostate cancer
umor cells, immune cells and stromal cells jointly modify tumor development and progression. We aim to explore the potential effects of tumor purity on the immune microenvironment, genetic landscape and progno...
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Open AccessVemurafenib inhibits necroptosis in normal and pathological conditions as a RIPK1 antagonist
Necroptosis, a programmed cell death with necrotic-like morphology, has been recognized as an important driver in various inflammatory diseases. Inhibition of necroptosis has shown potential promise in the the...
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Open AccessPreclinical development and evaluation of nanobody-based CD70-specific CAR T cells for the treatment of acute myeloid leukemia
Acute myeloid leukemia (AML) treatment remains challenging. CD70 was reported as a promising AML-specific antigen. Preclinically, CAR T-cell with single-chain-variable fragment (scFv) or truncated CD27 targeti...
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Ecotoxicological risk assessment of 14 pesticides and corresponding metabolites to groundwater and soil organisms using China-PEARL model and RQ approach
Global use of pesticides brings uncertain risks to human and nontarget species via environmental matrix. Currently, various models for exposure risk assessment are developed and widely used to forecast the imp...
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Open AccessRadiotherapy combined with anti-CEACAM1 immunotherapy to induce survival advantage in glioma
We aimed to observe the effect of radiotherapy on the expression of immune checkpoint molecule CEACAM1 in patients with glioma and the therapeutical effect of radiotherapy combined with blockade of CEACAM1 in ...
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Open AccessTransarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)
There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...
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Article
Residual analysis of QoI fungicides in multiple (six) types of aquatic organisms by UPLC-MS/MS under acutely toxic conditions
In view of the significance of food safety and the possible relationship between residual enrichment and acute toxicity for pesticides in different aquatic organisms, it is essential to establish a sensitive a...
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Article
Optimal time point of response assessment for predicting survival is associated with tumor burden in hepatocellular carcinoma receiving repeated transarterial chemoembolization
Objective response rate (ORR) under mRECIST criteria after transarterial chemoembolization (TACE) is a well-perceived surrogate endpoint of overall survival (OS). However, its optimal time point remains contro...
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Open AccessA Global Building Occupant Behavior Database
This paper introduces a database of 34 field-measured building occupant behavior datasets collected from 15 countries and 39 institutions across 10 climatic zones covering various building types in both commer...
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Open AccessHigh-throughput production of functional prototissues capable of producing NO for vasodilation
Bottom-up synthesis of prototissues helps us to understand the internal cellular communications in the natural tissues and their functions, as well as to improve or repair the damaged tissues. The existed prot...
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Article
Open AccessT cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape
Bispecific chimeric antigen receptor T-cell (CAR-T) therapies have shown promising results in clinical trials for advanced B-cell malignancies. However, it is challenging to broaden the success of bispecific C...
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Simultaneous detection of ten kinds of insecticide residues in honey and pollen using UPLC-MS/MS with graphene and carbon nanotubes as adsorption and purification materials
An analytical method of simultaneous detection of ten insecticide residues in honey and pollen was established. The samples were purified with QuEChERS approach using new adsorbents and analyzed with UPLC-MS/M...