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Article
An MP-Newton method for finding orthogonal-max type critical points and its application for calculating multiple solutions of semilinear elliptic equations: part I—method
ln Li and Zhou (SIAM J Sci Comput 23:840–865, 2001), a minimax method for computing multiple solutions of semilinear elliptic equation by calculating critical points of its energy function is presented. But, t...
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Article
Open AccessSilk fibroin hydrogel adhesive enables sealed-tight reconstruction of meniscus tears
Despite orientationally variant tears of the meniscus, suture repair is the current clinical gold treatment. However, inaccessible tears in company with re-tears susceptibility remain unresolved. To extend men...
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Article
Identification of biomarkers and potential therapeutic targets of kidney stone disease using bioinformatics
Kidney stone disease (KSD) is a common urological disease, but its pathogenesis remains unclear. In this study, we screened KSD-related hub genes using bioinformatic methods and predicted the related pathways ...
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Open AccessPiezo channels in the urinary system: Correspondence
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Article
Synthetic bone grafting with preserved cartilage flap via a medial malleolus osteotomy approach to treat osteochondral lesion of the talus: technical note and preliminary clinical results
Although various surgical procedures are available for osteochondral lesion of the talus (OLT), there is still no consensus on its best treatment. The purposes of this study were to describe a new surgical tec...
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Article
Deletion of DYRK1A Accelerates Osteoarthritis Progression Through Suppression of EGFR-ERK Signaling
Dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) signaling is involved in the dynamic balance of catabolism and anabolism in articular chondrocytes. This study aimed to investigate the ro...
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Primary malignant lymphoma of the ureter: a case report
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Perioperative change of circulating tumor cells in cytoreductive radical prostatectomy for oligometastatic hormone-sensitive prostate cancer: the preliminary safety evidence from long-term oncologic outcomes
Surgical manipulation has a risk of triggering the shedding of circulating tumor cells (CTCs) in patients with malignancies, However, perioperative change of circulating tumor cells in cytoreductive radical pr...
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Article
Effect of tumor CD276 expression on infiltrating immune cells and clinicopathological features of prostate cancer
Advanced prostate cancer (PCa) is often resistant to immunotherapy. In this study, we examined the role of CD276 in mediating immunotherapeutic effects through changes in immune cell infiltration.
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Article
Open AccesspiRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination
Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tiss...
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Open AccessHigh-resolution aging niche of human adipose tissues
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Open Accessm6A regulator-mediated methylation modification patterns and immune microenvironment infiltration characterization in osteoarthritis
Osteoarthritis (OA) is a common disease in orthopedics. RNA N6-methyladenosine (m6A) exerts an essential effect in a variety of biological processes in the eukaryotes. In this study, we determined the effect o...
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Article
Open AccessHypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis
Early studies indicated that the androgen receptor (AR) could promote renal cell carcinoma (RCC) development and metastasis, but its linkage to RCC progression under hypoxia, remains unclear.
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Article
Open AccessGeneration of ring-shaped human iPSC-derived functional heart microtissues in a Möbius strip configuration
Although human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been used for disease modeling and drug discovery, clinically relevant three-dimensional (3D) functional myocardial microtis...
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Article
Open AccessSFRP4+ stromal cell subpopulation with IGF1 signaling in human endometrial regeneration
Our understanding of full-thickness endometrial regeneration after injury is limited by an incomplete molecular characterization of the cell populations responsible for the organ functions. To help fill this k...
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Article
Open AccessDiagnostic biomolecules and combination therapy for pre-eclampsia
Pre-eclampsia (PE), associated with placental malperfusion, is the primary reason for maternal and perinatal mortality and morbidity that can cause vascular endothelial injury and multi-organ injury. Despite c...
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Article
Open AccessTransfection with Plasmid-Encoding lncRNA-SLERCC nanoparticle-mediated delivery suppressed tumor progression in renal cell carcinoma
The accumulating evidence confirms that long non-coding RNAs (lncRNAs) play a critical regulatory role in the progression of renal cell carcinoma (RCC). But, the application of lncRNAs in gene therapy remains ...
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Article
Open AccessUrological cancer organoids, patients' avatars for precision medicine: past, present and future
Urological cancers are common malignant cancers worldwide, with annually increasing morbidity and mortality rates. For decades, two-dimensional cell cultures and animal models have been widely used to study th...
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Article
Open AccessDistant metastasis without regional progression in non-muscle invasive bladder cancer: case report and pooled analysis of literature
Non-muscle invasive bladder cancer (NMIBC) represents the majority of bladder neoplasms. It is unusual for NMIBC metastasizing distantly without regional progression, namely metastatic NMIBC (mNMIBC), which is...
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Article
Long-term sexual dysfunction and hypotensive shock in a patient with a pheochromocytoma