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Article
MKI67 with arterial hypertension predict a poor survival for prostate cancer patients, a real-life investigation
Prostate cancer is a common urology malignant in males, ranking second globally. The disease is especially severe when diagnosed alongside hypertension. MKI67 is an established marker of neoplastic cell prolif...
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Article
Succession of bacterial community during microbially driven cyanobacterial organic matter degradation and its relationship to water quality in Taihu Lake, China
Anthropogenic eutrophication continuously degrades aquatic ecosystems and has led to a high frequency of massive cyanobacterial blooms in Taihu Lake since 1980. After bloom-forming cyanobacteria begin to disap...
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Article
Effects of discharge current and discharge duration on the crater morphology in single-pulse arc machining of Ti6Al4V
Electrical arc machining (EAM) technology offers a competitive and efficient method for removing material from Ti6Al4V alloys. This study investigates the crater morphology and efficient material removal chara...
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Article
Open AccessRecalcitrant dissolved organic matter in lakes: a critical but neglected carbon sink
Lakes are hotspots for the biogeochemical processing of carbon, including dissolved organic matter (DOM). A less degradable fraction of DOM, preserved for a long time, can be categorized as recalcitrant DOM (R...
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Article
Open AccessThe m6A reader IGF2BP2 regulates glycolytic metabolism and mediates histone lactylation to enhance hepatic stellate cell activation and liver fibrosis
Evidence for the involvement of N6-Methyladenosine (m6A) modification in the etiology and progression of liver fibrosis has emerged and holds promise as a therapeutic target. Insulin-like growth factor 2 (IGF2) m...
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Article
Construction and assessment of an indicator system of stream conditions in a typical mountain landscape in Northeast China
Stream ecosystem health assessments are crucial for the effective management of aquatic ecosystem service functions and the assessment of anthropogenic and climatic impacts on aquatic ecosystems. However, ther...
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Article
The difference between the dynamic deformation properties of rock material under seismic load and cyclic loading: a case study on Kobe wave
To study the dynamic mechanical properties of rock materials under seismic loads, seismic loads are generally simplified to constant amplitude cyclic loads due to the limitations of test equipment and conditio...
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Article
Open AccessTumor cell density dependent IL-8 secretion induces the fluctuation of tregs/CD8 + T cells infiltration in hepatocellular carcinoma: one prompt for the existence of density checkpoint
Tumor cell density is a basic pathological feature of solid tumors. Chemotherapy, radiotherapy, and targeted therapy reduce tumor cell density, whereas unrestricted tumor cell proliferation promotes this featu...
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Article
Post-failure analysis of landslide blocking river using the two-phase double-point material point method: a case of western Hubei, China
Due to the typical topography and hydrological characteristics in western Hubei's mountain and gorge areas, the landslide-surge-barrier dam disaster chain is the prevalent geological disasters. This research ...
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Article
Open AccessNK cells are never alone: crosstalk and communication in tumour microenvironments
Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) cell-based immunotherapy, which beco...
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Article
Stability evaluation of the high fill deposit slope subjected to rainfall considering water deterioration
In this study, three various types of rainfall with the measured rainfall events and data are used to analyze the stability of the high-fill deposit slope taking the influence of water deterioration into accou...
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Article
Influence of cyanobacterial bloom accumulation and dissipation on underwater light attenuation in a large and shallow lake
Cyanobacterial bloom accumulation and dissipation frequently occur in Lake Taihu, a typically shallow, eutrophic lake due to wind wave disturbance. However, knowledge of the driving mechanisms of cyanobacteria...
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Article
Open AccessScreening saikosaponin d (SSd)-producing endophytic fungi from Bupleurum scorzonerifolium Willd
Saikosaponin d (SSd) is an important bioactive compound of traditional Chinese medicinal plant Bupleurum scorzonerifolium Willd. and exhibits many effects, such as anti-tumor, anti-inflammation and immunomodulato...
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Article
Open AccessUrban and agricultural land use regulates the molecular composition and bio-lability of fluvial dissolved organic matter in human-impacted southeastern China
Urbanization and agricultural land use can increase the transport of nutrients to fluvial ecosystems; yet, the overall impact of urban and nonpoint agricultural inputs on the composition, bio-lability, and the...
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Article
The Dynamic Deformation Properties of Rock Materials Under Different Types of Seismic Load
The dynamic behaviors of rock under different seismic loads are numerically simulated.
The proper...
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Article
The Dynamic Mechanical Properties of a Hard Rock Under True Triaxial Damage-Controlled Dynamic Cyclic Loading with Different Loading Rates: A Case Study
A dynamic constitutive model for rock materials suited to dynamic cyclic loading was established.
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Article
The failure mode of transmission tower foundation on the landslide under heavy rainfall: a case study on a 500-kV transmission tower foundation on the Yanzi landslide in Badong, China
Due to topographical restrictions, transmission towers will inevitably be erected in areas prone to frequent geological disasters such as steep slope failure. Taking the Yanzi tower foundation landslide as the...
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Article
Open AccessGly-tRF enhances LCSC-like properties and promotes HCC cells migration by targeting NDFIP2
Accumulating evidence demonstrates that tRFs (tRNA-derived small RNA fragments) and tiRNAs (tRNA-derived stress-induced RNA), an emerging category of regulatory RNA molecules derived from transfer RNAs (tRNAs)...
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Article
The relationship between dynamic strength and strain rate and damage to rock materials subjected to dynamic cyclic loading
Induced and natural earthquakes will put the rock underground engineering in a state of dangerous destruction during the mining of resources, such as oil and gas. The form of seismic load is regarded as a dyna...
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Article
Experimental study for the effect of joint surface characteristics on stress wave propagation
Induced seismicity might occur during underground energy and resource exploitation. Seismic waves usually attenuate during propagation across rock joints. Joint surface configuration parameters such as the joi...
