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Article
Open AccessTowards a conceptual design framework for bee botanic gardens: integrating perceptions on urban biodiversity into landscape design processes
Botanic gardens, valued for their live plant collections, have evolved into scientific institutions with roles in conservation, education, research, and public recreation. This study repositions botanic garden...
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Article
Open AccessHemophagocytic lymphohistiocytosis: current treatment advances, emerging targeted therapy and underlying mechanisms
Hemophagocytic lymphohistiocytosis (HLH) is a rapidly progressing, life-threatening syndrome characterized by excessive immune activation, often presenting as a complex cytokine storm. This hyperactive immune ...
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Article
Mutation spectrum and genotype-phenotype correlation of pediatric patients with methylmalonic acidemia
MMA incidence is significantly greater in China than in the rest of the world, but the mutation spectrum of MMA in China has not yet been mapped.
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Article
Open AccessThe U-shaped association between serum direct bilirubin and incident mild cognitive impairment in hemodialysis patients: a multicenter study
Previous studies have suggested an association between low serum bilirubin concentrations and increased risk of cognitive impairment. This study aimed to explore the association and dose-response relationship ...
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Article
Transformation risk and associated survival outcome of marginal zone lymphoma: A nationwide study
Histological transformation into an aggressive B-cell lymphoma indicates a poor survival outcome for patients with indolent marginal zone lymphoma (MZL), which has been less studied. Large-scale data with long...
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Article
Episodic memory impairment and its influencing factors in individuals with autism spectrum disorder: systematic review and meta-analysis
Individuals with autism spectrum disorders (ASD) are considered to experience difficulties with episodic memory (EM), while studies on EM in ASD have shown inconsistent results. A meta-analysis of 65 episodic ...
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Article
Integrating Large Language Models in Bioinformatics Education for Medical Students: Opportunities and Challenges
Large language models (LLMs) offer transformative opportunities in bioinformatics education for medical students by creating interactive experiences. The integration of LLMs enhances educational outcomes throu...
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Article
Emission of greenhouse gases from sewer networks: field assessment and isotopic characterization
Sewer networks play a vital role in sewage collection and transportation, and they are being rapidly expanded. However, the microbial processes occurring within these networks have emerged as significant contr...
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Article
Model predictive control for a bending pneumatic muscle based on an online modified generalized Prandtl–Ishlinskii model
Pneumatic actuators exhibit significant potential across various applications owing to their compliance, yet achieving precise motion control remains challenging due to rate-dependent and asymmetric hysteresis...
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Article
Open AccessTrajectory of mid-arm subcutaneous fat, muscle mass predicts mortality in hemodialysis patients independent of body mass index
Although decreasing body mass index (BMI) is associated with higher mortality risk in patients undergoing hemodialysis (HD), BMI neither differentiates muscle and fat mass nor provides information about the va...
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Article
Open AccessRegulatory effects of Trichinella spiralis serpin-type serine protease inhibitor on endoplasmic reticulum stress and oxidative stress in host intestinal epithelial cells
Endoplasmic reticulum stress (ERS) and oxidative stress (OS) are adaptive responses of the body to stressor stimulation. Although it has been verified that Trichinella spiralis (T. spiralis) can induce ERS and OS...
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Article
Open AccessOff-Axis Co-Optical Path Large-Range Line Scanning Chromatic Confocal Sensor
This article proposes a line scanning chromatic confocal sensor to solve the problem of limited chromatic confocal measurement due to the small measurement range and low measurement efficiency in the industria...
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Article
Open AccessTubulin alpha-1b chain was identified as a prognosis and immune biomarker in pan-cancer combing with experimental validation in breast cancer
The α-tubulin subtype, Tubulin α-1b chain (TUBA1B), has been shown to influence immune cell infiltration, cancer growth, and survival across various malignancies. However, a comprehensive study has not yet bee...
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Article
Open AccessAbnormal biochemical indicators of neonatal inherited metabolic disease in carriers
Traditional biochemical screening for neonatal inherited metabolic diseases has high false-positive rates and low positive predictive values, which are not conducive to early diagnosis and increase parents’ an...
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Article
Open AccessA redeemed strategy for molecular autopsy in unexplained infant deaths
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Open AccessComparative genomic analysis of the Growth-Regulating Factors-Interacting Factors (GIFs) in six Salicaceae species and functional analysis of PeGIF3 reveals their regulatory role in Populus heteromorphic leaves
The growth-regulating factor-interacting factor (GIF) gene family plays a vital role in regulating plant growth and development, particularly in controlling leaf, seed, and root meristem homeostasis. However, the...
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Article
Open AccessDevelopment and validation of a model for predicting the risk of cardiovascular events in maintenance hemodialysis patients
The mortality rates for patients undergoing hemodialysis (HD) remain unacceptably high compared to the general population, and more specific information about the causes of death is not known. The study aimed ...
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Article
Effects of the Glucocorticoid-Mediated Mitochondrial Translocation of Glucocorticoid Receptors on Oxidative Stress and Pyroptosis in BV-2 Microglia
Microglia are resident macrophages within the central nervous system, serving as the first responders to neuroinflammation. Glucocorticoids (GCs) may cause damage to brain tissue, but the specific mechanism re...
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Article
Open AccessTumorous IRE1α facilitates CD8+T cells-dependent anti-tumor immunity and improves immunotherapy efficacy in melanoma
Tumor cells frequently suffer from endoplasmic reticulum (ER) stress. Previous studies have extensively elucidated the role of tumorous unfolded protein response in melanoma cells, whereas the effect on tumor ...
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Article
Molecular pathway of mitochondrial preprotein import through the TOM–TIM23 supercomplex
Over half of mitochondrial proteins are imported from the cytosol via the pre-sequence pathway, controlled by the TOM complex in the outer membrane and the TIM23 complex in the inner membrane. The mechanisms t...
