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558 Result(s)
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Article
Open AccessGingipain from Porphyromonas gingivalis causes insulin resistance by degrading insulin receptors through direct proteolytic effects
Periodontitis is a critical risk factor for the occurrence and development of diabetes. Porphyromonas gingivalis may participate in insulin resistance (IR) caused by periodontal inflammation, but the functional r...
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Open AccessTGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra (SN). Activation of the neuroinflammatory response has a pivotal role ...
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Open AccessDivergent evolution of male-determining loci on proto-Y chromosomes of the housefly
Houseflies provide a good experimental model to study the initial evolutionary stages of a primary sex-determining locus because they possess different recently evolved proto-Y chromosomes that contain male-de...
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Open AccessBoosting Electrochemical Urea Synthesis via Constructing Ordered Pd–Zn Active Pair
Ordered intermetallic pallium-zinc (PdZn) electrocatalyst comprising a high density of PdZn pairs is synthesized for achieving co-adsorption and co-activation carbon dioxide an...
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Emission of greenhouse gases from sewer networks: field assessment and isotopic characterization
Sewer networks play a vital role in sewage collection and transportation, and they are being rapidly expanded. However, the microbial processes occurring within these networks have emerged as significant contr...
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LncRNA BBOX1-AS1 Contributes to Laryngeal Carcinoma Progression by Recruiting SRSF1 to Maintain EFNB2 mRNA Stability
Laryngeal cancer is a common malignancy of the larynx with a generally poor prognosis. This study systematically assessed the functional role of lncRNA BBOX1-AS1 in laryngeal carcinoma progression and associat...
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Photonics joint radar and communication system using dual-band LFM-based signals with opposite chirp polarities
A photonics joint radar and communication (JRC) system using dual-band linear frequency modulation (LFM)-based waveforms is proposed and demonstrated. In the scheme, four optical chirp sidebands are generated ...
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Characterization and utilization potential of typical molybdenum tailings in Shaanxi Province, China
Shaanxi Province is located in the most important molybdenum ore district in the world, but a lot of molybdenum tailings have been released, polluting the environment and wasting resources seriously. Taking el...
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mRNA vaccine technology for infectious diseases and beyond
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Prescribed Performance Control for the Lower Limb Exoskeleton With Time-varying State Constraints and Input Saturation
This paper studies the problem of prescribed performance tracking control for the lower limb exoskeleton under time-varying state constraints and input saturation. A prescribed performance control method is pr...
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Nonlinear passive magnetorheological damping characteristics of the scissor-like isolation platform
Scissor-like isolation platform (SIP) with magnetorheological damper (MRD) has been commonly studied and applied successfully in vehicle vibration isolation. This paper concerns passive nonlinear magnetorheolo...
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Open AccessBioinformatics analysis of signature genes related to cell death in keratoconus
Keratoconus is corneal disease in which the progression of conical dilation of cornea leads to reduced visual acuity and even corneal perforation. However, the etiology mechanism of keratoconus is still unclea...
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Open AccessExpanding the targeting scope of CRISPR/Cas9-mediated genome editing by Cas9 variants in Brassica
CRISPR/Cas9, presently the most widely used genome editing technology, has provided great potential for functional studies and plant breeding. However, the strict requirement for a protospacer adjacent motif (...
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A Heterogeneous Quasi-solid-State Hybrid Electrolyte Constructed from Electrospun Nanofibers Enables Robust Electrode/Electrolyte Interfaces for Stable Lithium Metal Batteries
Quasi-solid-state electrolytes that possess high ionic conductivity, excellent interface stability, and low interfacial resistance, are required for practical solid-state batteries. Herein, a heterogeneous qua...
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Cascade genetic testing for hereditary cancer syndromes: a review of barriers and breakthroughs
Germline genetic sequencing is now at the forefront of cancer treatment and preventative medicine. Cascade genetic testing, or the testing of at-risk relatives, is extremely promising as it offers genetic test...
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Open AccessA simplified herbal decoction attenuates myocardial infarction by regulating macrophage metabolic reprogramming and phenotypic differentiation via modulation of the HIF-1α/PDK1 axis
Myocardial infarction (MI) poses a global public health challenge, often associated with elevated mortality rates and a grim prognosis. A crucial aspect of the inflammatory injury and healing process post-MI i...
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Open AccessLag effect of ambient temperature on respiratory emergency department visits in Beijing: a time series and pooled analysis
Although the association between ambient temperature and mortality of respiratory diseases was numerously documented, the association between various ambient temperature levels and respiratory emergency depart...
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Preliminary Analysis of the End Friction Effect on Dynamic Compressive Strength of Rocks
Accurate measurement of dynamic behaviors of rocks under complex static stress conditions can provide valuable insight into the design of underground rock engineering. The end friction between the specimen and...
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Rethinking group activity recognition under the open set condition
In real-world scenarios, the recognition of unknown activities poses a significant challenge for group activity recognition. Existing methods primarily focus on closed sets, leaving the task of open set group ...
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Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries