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Article
Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank
Suicide is a global public health challenge, yet considerable uncertainty remains regarding the associations of both behaviour-related and physiological factors with suicide attempts (SA). Here we first estima...
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Article
Open AccessDDAH-1 maintains endoplasmic reticulum-mitochondria contacts and protects dopaminergic neurons in Parkinson’s disease
The loss of dopaminergic neurons in the substantia nigra is a hallmark of pathology in Parkinson’s disease (PD). Dimethylarginine dimethylaminohydrolase-1 (DDAH-1) is the critical enzyme responsible for the de...
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Article
Open AccessExpanding the targeting scope of CRISPR/Cas9-mediated genome editing by Cas9 variants in Brassica
CRISPR/Cas9, presently the most widely used genome editing technology, has provided great potential for functional studies and plant breeding. However, the strict requirement for a protospacer adjacent motif (...
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Article
Open AccessPeripheral immunity and risk of incident brain disorders: a prospective cohort study of 161,968 participants
Whether peripheral immunity prospectively influences brain health remains controversial. This study aims to investigate the longitudinal associations between peripheral immunity markers with incident brain dis...
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Article
Open AccessAuthor Correction: The brain structure, immunometabolic and genetic mechanisms underlying the association between lifestyle and depression
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Article
Open AccessThe brain structure, immunometabolic and genetic mechanisms underlying the association between lifestyle and depression
Lifestyle factors have been acknowledged to be modifiable targets that can be used to counter the increasing prevalence of depression. This study aims to investigate combining an extensive range of lifestyle f...
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Article
Open AccessSleep patterns correlates with the efficacy of tDCS on post-stroke patients with prolonged disorders of consciousness
The subclassification of prolonged disorders of consciousness (DoC) based on sleep patterns is important for the evaluation and treatment of the disease. This study evaluates the correlation between polysomnog...
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Article
Author Correction: The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health
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Article
The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health
Sleep duration, psychiatric disorders and dementias are closely interconnected in older adults. However, the underlying genetic mechanisms and brain structural changes are unknown. Using data from the UK Bioba...
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Article
Open AccessRecommendations for the diagnosis and treatment of paroxysmal kinesigenic dyskinesia: an expert consensus in China
Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes. Paroxysmal kinesigenic dyskinesia (PKD) is the most common typ...
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Article
Open AccessIndividual brain metabolic connectome indicator based on Kullback-Leibler Divergence Similarity Estimation predicts progression from mild cognitive impairment to Alzheimer’s dementia
Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) reveals altered cerebral metabolism in individuals with mild cognitive impairment (MCI) and Alzheimer’s dementia (AD). Previous metabolic conne...
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Article
Meta-analysis of the association between the dietary inflammatory index (DII) and breast cancer risk
Recent studies have reported mixed results on the association between the pro-inflammatory dietary index and risk of breast cancer. We perform this comprehensive meta-analysis to figure out whether high dietar...
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Article
Open AccessGenome-wide association study identified ATP6V1H locus influencing cerebrospinal fluid BACE activity
The activity of cerebrospinal fluid (CSF) β-site APP cleaving enzyme (BACE) is a potential diagnostic biomarker for Alzheimer disease (AD).
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Chapter and Conference Paper
Identifying Genetic Associations with MRI-derived Measures via Tree-Guided Sparse Learning
In recent imaging genetic studies, much work has been focused on regression analysis that treats large-scale single nucleotide polymorphisms (SNPs) and quantitative traits (QTs) as association variables. To de...