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Chapter and Conference Paper
Document-Level Relation Extraction with Relation Correlation Enhancement
Document-level relation extraction (DocRE) is a task that focuses on identifying relations between entities within a document. However, existing DocRE models often overlook the correlation between relations an...
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Article
Open AccessXinyang tablet ameliorates sepsis-induced myocardial dysfunction by regulating Beclin-1 to mediate macrophage autophagy and M2 polarization through LncSICRNT1 targeting E3 ubiquitin ligase TRAF6
Xinyang Tablet (XYT) has emerged as a potential intervention to counter sepsis-induced myocardial dysfunction (SMID) by influencing macrophage autophagy and M2 polarization. This study aimed to unravel the und...
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Article
Open AccessMolecular mechanism of lncRNA SNHG12 in immune escape of non-small cell lung cancer through the HuR/PD-L1/USP8 axis
The pivotal role of long noncoding RNAs (lncRNAs) in cancer immune responses has been well established. This study was conducted with the aim of exploring the molecular mechanism of lncRNA small nucleolar RNA ...
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Article
First-line treatment options for advanced non-small cell lung cancer patients with PD-L1 ≥ 50%: a systematic review and network meta-analysis
Single-agent immune checkpoint inhibitors (ICIs) like pembrolizumab or atezolizumab have been approved as first-line monotherapy for advanced non-small cell lung cancer (NSCLC) patients with PD-L1 ≥ 50%. Howev...
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Article
Successful management of lung adenocarcinoma with ALK/EGFR co-alterations and PD-L1 over-expression by bevacizumab combined with chemotherapy
Anaplastic lymphoma kinase (ALK)/epidermal growth factor receptor (EGFR) co-alterations in adenocarcinomas are rare and no therapeutic consensus is reached. The potentially negative prognostic effects of progr...
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Article
Open AccessAge-related accumulation of advanced oxidation protein products promotes osteoclastogenesis through disruption of redox homeostasis
Enhanced osteoclastogenesis is one of the major causes of age-related bone loss. Aging is accompanied by accumulation of advanced oxidation protein products (AOPPs). However, whether AOPPs accumulation contrib...
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Article
Open AccessKnockout RAGE alleviates cardiac fibrosis through repressing endothelial-to-mesenchymal transition (EndMT) mediated by autophagy
Endothelial-to-mesenchymal transition (EndMT) has been shown to contribute to cardiac fibrosis and heart failure (HF). Recent studies have demonstrated that EndMT is regulated by autophagy, and we previously s...
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Article
Open AccessIdentification of LINC00665-miR-let-7b-CCNA2 competing endogenous RNA network associated with prognosis of lung adenocarcinoma
Prognosis of patients with lung cancer remains extremely poor; thus, we sought to unearth novel competing endogenous RNA (ceRNA) networks associated with the prognosis of lung adenocarcinoma (LUAD). Aberrant m...
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Article
Open AccessConstruction of an 11-microRNA-based signature and a prognostic nomogram to predict the overall survival of head and neck squamous cell carcinoma patients
Head and neck squamous cell carcinoma (HNSCC) is a fatal malignancy owing to the lack of effective tools to predict overall survival (OS). MicroRNAs (miRNAs) play an important role in HNSCC occurrence, develop...
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Article
Open AccessPyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload
Chronic heart failure (CHF) is the final outcome of many cardiovascular diseases, and is a severe health issue faced by the elderly population. Mixed lineage kinase 3 (MLK3), a member of MAP3K family, is assoc...
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Chapter and Conference Paper
Attention-Based Aggregation Graph Networks for Knowledge Graph Information Transfer
Knowledge graph completion (KGC) aims to predict missing information in a knowledge graph. Many existing embedding-based KGC models solve the Out-of-knowledge-graph (OOKG) entity problem (also known as zero-sh...
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Article
Research on multi-kilowatts level tapered fiber bundle N×1 pumping combiner for high power fiber laser
Pumping combiner is a kernel component of high power fiber laser (HPFL). We demonstrate two types of tapered fiber bundle (TFB) end-pumping combiner able to combining multi-kilowatts of pumping laser. After th...
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Article
TSSC3 overexpression reduces stemness and induces apoptosis of osteosarcoma tumor-initiating cells
Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents, typically presenting with poor prognosis. Recent studies suggested that tumor initiating cells (T-ICs) drive tumor formation...
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Article
The several transformation formula in several complex variables and its applications
In this paper, by the method of global analysis, the authors give a new global integral transformation formula and obtain the Plemelj formula with Hadamard principal value of higher-order partial derivatives f...
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Chapter and Conference Paper
Effect Assessment of Low Temperature Water in Reservior on the Growth of Wheat
In China, the ecologic impacts of hydropower development have drawn the society’s great attention, especially, the impact assessment of low-temperature water for huge reservoir is the necessary chapter in the ...