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Open AccessHMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway
Esophageal squamous cell carcinoma (ESCC) possesses a poor prognosis and treatment outcome. Dysregulated metabolism contributes to unrestricted growth of multiple cancers. However, abnormal metabolism, such as...
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Article
Open AccessMi-2β promotes immune evasion in melanoma by activating EZH2 methylation
Recent development of new immune checkpoint inhibitors has been particularly successfully in cancer treatment, but still the majority patients fail to benefit. Converting resistant tumors to immunotherapy sens...
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Open AccessO-GlcNAc of STING mediates antiviral innate immunity
O-GlcNAcylation modification affects multiple physiological and pathophysiolocal functions of cells. Altered O-GlcNAcylation was reported to participate in antivirus response. Stimulator of interferon genes (S...
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Open AccessHMGA1 drives chemoresistance in esophageal squamous cell carcinoma by suppressing ferroptosis
Chemotherapy is a primary treatment for esophageal squamous cell carcinoma (ESCC). Resistance to chemotherapeutic drugs is an important hurdle to effective treatment. Understanding the mechanisms underlying ch...
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Open AccessLactylation stabilizes DCBLD1 activating the pentose phosphate pathway to promote cervical cancer progression
Discoidin, CUB, and LCCL domain-containing type I (DCBLD1) is identified as an oncogene involved in multiple regulation of tumor progression, but specific mechanisms remain unclear in cervical cancer. Lactate-...
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Open AccessThe regulations of telomerase reverse transcriptase (TERT) in cancer
Abnormal activation of telomerase occurs in most cancer types, which facilitates escaping from cell senescence. As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by vario...
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Open AccessTargeted changes in blood lipids improves fibrosis in renal allografts
Chronic interstitial fibrosis is the primary barrier against the long-term survival of transplanted kidneys. Extending the lifespan of allografts is vital for ensuring the long-term health of patients undergoi...
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Open AccessShort-chain fatty acids in diseases
Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate transporters, such a...
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Open AccessThe protective role of MC1R in chromosome stability and centromeric integrity in melanocytes
Variants in the melanocortin-1 receptor (MC1R) gene, encoding a trimeric G-protein-coupled receptor and activated by α-melanocyte-stimulating hormone (α-MSH), are frequently associated with red or blonde hair, fa...
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Open AccessElevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
Mutations that inactivate negative translation regulators cause autism spectrum disorders (ASD), which predominantly affect males and exhibit social interaction and communication deficits and repetitive behavi...
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Open AccessCaspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
Caspase-2 is the most evolutionarily conserved member in the caspase family of proteases and is constitutively expressed in most cell types including neurons; however, its physiological function remains largel...
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The influence of dissociation reaction on ammonium nitrate thermal decomposition reaction
In order to investigate the influence of dissociation reaction on thermal decomposition of ammonium nitrate (AN), biochar was selected as an adsorbent to interfere with the dissociation of AN. The TG-DSC resul...
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Epidemiological trends and virological traits of hepatitis B virus infection in pregnant women and neonates
In infants, hepatitis B virus (HBV) infections are mainly acquired by mother-to-child transmission (MTCT). Current tests for the presence of HBV markers at birth can neither confirm nor exclude MTCT. The aim o...
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Open AccessTargeting MC1R depalmitoylation to prevent melanomagenesis in redheads
Some genetic melanocortin-1 receptor (MC1R) variants responsible for human red hair color (RHC-variants) are consequently associated with increased melanoma risk. Although MC1R signaling is critically dependen...
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Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy
Programmed cell death ligand 1 (PD-L1) interacts with programmed cell death protein-1 (PD-1) as an immune checkpoint. Reactivating the immune response by inhibiting PD-L1 using therapeutic antibodies provides sub...
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Piperlongumine and p53-reactivator APR-246 selectively induce cell death in HNSCC by targeting GSTP1
TP53 mutations frequently occur in head and neck squamous cell carcinoma (HNSCC) patients without human papillomavirus infection. The recurrence rate for these patients is distinctly high. It has been actively...
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Open AccessThe protective role of DOT1L in UV-induced melanomagenesis
The DOT1L histone H3 lysine 79 (H3K79) methyltransferase plays an oncogenic role in MLL-rearranged leukemogenesis. Here, we demonstrate that, in contrast to MLL-rearranged leukemia, DOT1L plays a protective ro...
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Thermal stability of ammonium nitrate in high-temperature coal seam
In order to investigate safety of blasting process in high-temperature coal seam, thermal decomposition characteristic of ammonium nitrate (AN) with coal was studied. The characteristic of HTCS was investigate...
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Palmitoylation-dependent activation of MC1R prevents melanomagenesis
The protein modification palmitoylation increases the ability of variant forms of the melanocortin-1 receptor (MC1R) to induce pigmentation, and this is linked to reduced development of melanomas.
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Open AccessFocal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis
Understanding the underlying molecular mechanisms of liver fibrosis is important to develop effective therapy. Herein, we show that focal-adhesion-kinse (FAK) plays a key role in promoting hepatic stellate cel...