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Article
Open AccessRelationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia
Increasing evidence suggested that immune abnormalities involved in the pathophysiology of schizophrenia. However, the relationship between immunity and clinical features has not been clarified. The aim of thi...
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Article
Open AccessHistory of suicidal behavior and clozapine prescribing among people with schizophrenia in China: a cohort study
Clozapine is an off-label drug used in most countries to prevent suicide in individuals with schizophrenia. However, few studies have reported real-world prescription practices. This study aimed to explore the...
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Article
Sphingomyelin-derived epacadostat nanovesicle enhances IDO1 inhibition for improved melanoma combination immunotherapy
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Article
Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia
Several studies have reported compromised white matter integrity, and that some inflammatory mediators may underlie this functional dysconnectivity in the brain of patients with schizophrenia. The immune-infla...
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Article
Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence
Alcohol dependence is a disorder with a high recurrence rate that leads to a considerable public health burden. The risk of relapse appears to be related to a complex interplay of multiple factors. Herein, we ...
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Article
Open AccessCholesterol-modified sphingomyelin chimeric lipid bilayer for improved therapeutic delivery
Cholesterol (Chol) fortifies packing and reduces fluidity and permeability of the lipid bilayer in vesicles (liposomes)-mediated drug delivery. However, under the physiological environment, Chol is rapidly ext...
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Article
Quantitative equidistribution and the local statistics of the spectrum of a flat torus
We show that a pair correlation function for the spectrum of a flat 2-dimensional torus satisfying an explicit Diophantine condition agrees with those of a Poisson process with a polynomial error rate.
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Article
Quantitative Almost Reducibility and Möbius Disjointness for Analytic Quasiperiodic Schrödinger Cocycles
Sarnak’s Möbius disjointness conjecture states that Möbius function is disjoint to any zero entropy dynamics. We prove that Möbius disjointness conjecture holds for one-frequency analytic quasi-periodic cocycl...
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Article
Open AccessSphingomyelin-derived nanovesicles for the delivery of the IDO1 inhibitor epacadostat enhance metastatic and post-surgical melanoma immunotherapy
Epacadostat (EPA), the most advanced IDO1 inhibitor, in combination with PD-1 checkpoint inhibitor, has failed in a recent Phase III clinical trial for treating metastatic melanoma. Here we report an EPA nanov...
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Article
An improved joint modeling method for multipath mitigation of GPS, BDS-3, and Galileo overlapping frequency signals in typical environments
The new generation of BDS-3 broadcasted open service signals B1C and B2a, which are compatible and interoperable with GPS and Galileo overlapping frequency signals, are suitable for multi-constellation global ...
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Article
Open AccessCSF1R regulates schizophrenia-related stress response and vascular association of microglia/macrophages
Microglia are known to regulate stress and anxiety in both humans and animal models. Psychosocial stress is the most common risk factor for the development of schizophrenia. However, how microglia/brain macrop...
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Article
History of suicide attempt associated with amygdala and hippocampus changes among individuals with schizophrenia
Abnormalities in subcortical brain structures may reflect higher suicide risk in mood disorders, but less is known about its associations for schizophrenia. This cross-sectional imaging study aimed to explore ...
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Article
The age of onset and cognitive impairment at the early stage of schizophrenia
In schizophrenia, the age of first episode onset can reflect genetic loading and predict prognosis. Little is known about the association between the age of onset and cognition among individuals with early-sta...
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Article
Open AccessMale-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain
Attention deficit hyperactivity disorder (ADHD) is associated with reduction of cortical and subcortical gray matter volumes (GMVs). The kinectin 1 gene (KTN1) has recently been reported to significantly regulate...
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Article
Open AccessAltered DNA methylation of CYP2E1 gene in schizophrenia patients with tardive dyskinesia
About 20–30% of patients with schizophrenia develop tardive dyskinesia (TD). Oxidative stress is one potential causes of TD. CYP2E1 is considered as an oxidative stress-related gene, however, no study has been re...
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Article
Open AccessAbnormal cortisol profile during psychosocial stress among patients with schizophrenia in a Chinese population
Accumulating evidence suggests that hypothalamic-pituitary-adrenal axis dysfunction might play an important role in the pathophysiology of schizophrenia. The aim of this study was to explore the cortisol respo...
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Article
Open AccessThe effect of transcranial direct current stimulation combined with working memory training on working memory deficits in schizophrenic patients: study protocol for a randomized controlled trial
Working memory deficits are one of the core and most characteristic clinical features of cognitive impairment in schizophrenia. Cognitive training can improve the cognitive function of patients with schizophre...
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Article
History of suicide attempts associated with the thinning right superior temporal gyrus among individuals with schizophrenia
Individuals with schizophrenia have higher rates of suicide attempts than the general population. Specific cortical abnormalities (e.g., the cortical surface area and thickness) may be associated with a histor...
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Article
Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy
Despite the enormous therapeutic potential of immune checkpoint blockade (ICB), it benefits only a small subset of patients. Some chemotherapeutics can switch ‘immune-cold’ tumours to ‘immune-hot’ to synergize...
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Article
Multipath mitigation in GNSS precise point positioning based on trend-surface analysis and multipath hemispherical map
The multipath effect reduces the accuracy of pseudorange and carrier phase observations and significantly affects the convergence of precise point positioning (PPP) in an urban high-obstruction environment. Th...