One of the founders of population genetics, Sewall Wright was an American geneticist who contribu... more One of the founders of population genetics, Sewall Wright was an American geneticist who contributed extensively in the area of inbreeding and evolution of allele frequencies which laid a foundation for future researchers. Wright talked about the effect of inbreeding in small populations known as the Sewall Wright Effect. This is commonly referred to as genetic drift. Wright said that small populations with individuals that carry rare genes may not transmit them to the next generation and these genes would eventually disappear and a new species would emerge. This random process results in the elimination of genetic variance and results in what we call today, inbreeding depression. Sewall Wright is most famous for Evolution in Mendelian Populations and his work on allele frequency evolution where he proposed a mathematical analysis to explain the changes in allele frequencies in response to evolutionary forces. Basically, allele frequencies change in response to natural selection, mutation, genetic drift and migration. Allele frequencies are affected by random chance or by selective pressures which are passed to offspring and can result in various outcomes such as increased or decreased fitness. Genetic drift is the change of allele frequencies in a population due to random chance. This effect is greatest seen in a smaller population size because it has a higher chance of fixation of alleles, thereby reducing the genetic variability present within the population. Genetic drift removes infrequent alleles which leads to fixation of alleles or genotypes in a population. This fixation of alleles within a population and subsequent mating leads to something known as inbreeding depression.
One of the founders of population genetics, Sewall Wright was an American geneticist who contribu... more One of the founders of population genetics, Sewall Wright was an American geneticist who contributed extensively in the area of inbreeding and evolution of allele frequencies which laid a foundation for future researchers. Wright talked about the effect of inbreeding in small populations known as the Sewall Wright Effect. This is commonly referred to as genetic drift. Wright said that small populations with individuals that carry rare genes may not transmit them to the next generation and these genes would eventually disappear and a new species would emerge. This random process results in the elimination of genetic variance and results in what we call today, inbreeding depression. Sewall Wright is most famous for Evolution in Mendelian Populations and his work on allele frequency evolution where he proposed a mathematical analysis to explain the changes in allele frequencies in response to evolutionary forces. Basically, allele frequencies change in response to natural selection, mutation, genetic drift and migration. Allele frequencies are affected by random chance or by selective pressures which are passed to offspring and can result in various outcomes such as increased or decreased fitness. Genetic drift is the change of allele frequencies in a population due to random chance. This effect is greatest seen in a smaller population size because it has a higher chance of fixation of alleles, thereby reducing the genetic variability present within the population. Genetic drift removes infrequent alleles which leads to fixation of alleles or genotypes in a population. This fixation of alleles within a population and subsequent mating leads to something known as inbreeding depression.
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