Abstract Lipofuscin is a membrane-bound cellular waste that can be neither degraded nor ejected f... more Abstract Lipofuscin is a membrane-bound cellular waste that can be neither degraded nor ejected from the cell but can only be diluted through cell division and subsequent growth. The fate of postmitotic (non-dividing) cells such as neurons, cardiac myocytes, skeletal muscle fibers, and retinal pigment epithelial cells (RPE) is to accumulate lipofuscin, which as an “aging pigment” has been considered a reliable biomarker for the age of cells. Environmental stress can accelerate the accumulation of lipofuscin. For example, ...
Age-related macular degeneration (AMD) is the leading cause of blindness beyond the age of 50 yea... more Age-related macular degeneration (AMD) is the leading cause of blindness beyond the age of 50 years. The most common pathogenic mechanism that leads to AMD is choroidal neovascularization (CNV). CNV is produced by accumulation of residual material caused by aging of retinal pigment epithelium cells (RPE). The RPE is a phagocytic system that is essential for renewal of photoreceptors (rods and cones). With time, incompletely degraded membrane material builds up in the form of lipofuscin. Lipofuscin is made of free-radical- ...
Malignant melanoma is nowadays one of the most frequent type of skin cancer among white-skinned p... more Malignant melanoma is nowadays one of the most frequent type of skin cancer among white-skinned populations and one of the most malignant tumors. In this work, we investigate fractal properties of color images of dermal tissue microscopic samples as a basis for detection of malignant melanoma lesions. The enhancement image process is applied to hematoxylin-eosin stained tissue samples microscopic images. A segmented image based on a color model attribute is processed with a local Hurst transformation added with edge ...
Age-related macular degeneration (AMD) is the leading cause of blindness beyond the age of 50 yea... more Age-related macular degeneration (AMD) is the leading cause of blindness beyond the age of 50 years. The most common pathogenic mechanism that leads to AMD is choroidal neovascularization (CNV). CNV is produced by accumulation of residual material caused by aging of retinal pigment epithelium cells (RPE). With time, incompletely degraded membrane material builds up in the RPE in the form of lipofuscin. Lipofuscin is made of free-radical-damaged protein and fat, which forms not only in AMD, but also Alzheimer disease ...
Various models have been proposed in order to explain the experimental measured values for the ex... more Various models have been proposed in order to explain the experimental measured values for the exponents that characterize the interface [2—4]. Amaral et al. con-sidered in particular, the in6uence of a gradient in the density of pinning sites of the porous medium. None of the proposed models takes into account the viscosity of the invading Quid although recently, a nonsolid-on-solid (non-SOS) model has been presented and the characteristics of the interface are studied for different viscosity ratios [5]. We present here a SOS model ...
Abstract A random deposition model with a non-linear threshold-governed diffusivity is presented.... more Abstract A random deposition model with a non-linear threshold-governed diffusivity is presented. Although lhe asymptotic regime of the model is random deposition, for lhe intermediate regime the model shows a non-txivial scaling behaviour with a more rapid than random growth
Although geomagnetic forecasting is extremely important, geomagnetic predictions usually rely on ... more Although geomagnetic forecasting is extremely important, geomagnetic predictions usually rely on forecasters' experience in distinguishing events expected to be geoeffective. Initial investigations with powerful forecasting techniques such as neural networks have recently been applied to geomagnetic prediction, but these are based on the assumption that the phenomenon to be forecasted has only several degrees of freedom. Thus a basic question related to geomagnetic forecasting is whether the randomness associated with ...
Abstract Lipofuscin is a membrane-bound cellular waste that can be neither degraded nor ejected f... more Abstract Lipofuscin is a membrane-bound cellular waste that can be neither degraded nor ejected from the cell but can only be diluted through cell division and subsequent growth. The fate of postmitotic (non-dividing) cells such as neurons, cardiac myocytes, skeletal muscle fibers, and retinal pigment epithelial cells (RPE) is to accumulate lipofuscin, which as an “aging pigment” has been considered a reliable biomarker for the age of cells. Environmental stress can accelerate the accumulation of lipofuscin. For example, ...
Age-related macular degeneration (AMD) is the leading cause of blindness beyond the age of 50 yea... more Age-related macular degeneration (AMD) is the leading cause of blindness beyond the age of 50 years. The most common pathogenic mechanism that leads to AMD is choroidal neovascularization (CNV). CNV is produced by accumulation of residual material caused by aging of retinal pigment epithelium cells (RPE). The RPE is a phagocytic system that is essential for renewal of photoreceptors (rods and cones). With time, incompletely degraded membrane material builds up in the form of lipofuscin. Lipofuscin is made of free-radical- ...
Malignant melanoma is nowadays one of the most frequent type of skin cancer among white-skinned p... more Malignant melanoma is nowadays one of the most frequent type of skin cancer among white-skinned populations and one of the most malignant tumors. In this work, we investigate fractal properties of color images of dermal tissue microscopic samples as a basis for detection of malignant melanoma lesions. The enhancement image process is applied to hematoxylin-eosin stained tissue samples microscopic images. A segmented image based on a color model attribute is processed with a local Hurst transformation added with edge ...
Age-related macular degeneration (AMD) is the leading cause of blindness beyond the age of 50 yea... more Age-related macular degeneration (AMD) is the leading cause of blindness beyond the age of 50 years. The most common pathogenic mechanism that leads to AMD is choroidal neovascularization (CNV). CNV is produced by accumulation of residual material caused by aging of retinal pigment epithelium cells (RPE). With time, incompletely degraded membrane material builds up in the RPE in the form of lipofuscin. Lipofuscin is made of free-radical-damaged protein and fat, which forms not only in AMD, but also Alzheimer disease ...
Various models have been proposed in order to explain the experimental measured values for the ex... more Various models have been proposed in order to explain the experimental measured values for the exponents that characterize the interface [2—4]. Amaral et al. con-sidered in particular, the in6uence of a gradient in the density of pinning sites of the porous medium. None of the proposed models takes into account the viscosity of the invading Quid although recently, a nonsolid-on-solid (non-SOS) model has been presented and the characteristics of the interface are studied for different viscosity ratios [5]. We present here a SOS model ...
Abstract A random deposition model with a non-linear threshold-governed diffusivity is presented.... more Abstract A random deposition model with a non-linear threshold-governed diffusivity is presented. Although lhe asymptotic regime of the model is random deposition, for lhe intermediate regime the model shows a non-txivial scaling behaviour with a more rapid than random growth
Although geomagnetic forecasting is extremely important, geomagnetic predictions usually rely on ... more Although geomagnetic forecasting is extremely important, geomagnetic predictions usually rely on forecasters' experience in distinguishing events expected to be geoeffective. Initial investigations with powerful forecasting techniques such as neural networks have recently been applied to geomagnetic prediction, but these are based on the assumption that the phenomenon to be forecasted has only several degrees of freedom. Thus a basic question related to geomagnetic forecasting is whether the randomness associated with ...
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