Rhinophyma is a slowly progressive, disfiguring disorder of the nose seen almost exclusively in m... more Rhinophyma is a slowly progressive, disfiguring disorder of the nose seen almost exclusively in men. It consists of large nodular masses of hypertrophic and hyperemic connective tissue and sebaceous glands. We present an 89-year-old white man with an unusual cystic variant of rhinophyma. While rhinophyma has 2 different presentations, our case contains not only both spectrums of histologic findings but also multiple cysts. These cysts were present on gross pathologic and microscopic examination and contained both squamous and mucinous epithelium.
Skeletal (striated) muscle is one of the four basic tissue types, together with the epithelium, c... more Skeletal (striated) muscle is one of the four basic tissue types, together with the epithelium, connective and nervous tissues. Lungs, on the other hand, develop from the foregut and among various cell types contain smooth, but not skeletal muscle. Therefore, during earlier stages of development, it is unlikely that skeletal muscle and lung depend on each other. However, during the later stages of development, respiratory muscle, primarily the diaphragm and the intercostal muscles, execute so called fetal breathing-like movements (FBMs), that are essential for lung growth and cell differentiation. In fact, the absence of FBMs results in pulmonary hypoplasia, the most common cause of death in the first week of human neonatal life. Most knowledge on this topic arises from in vivo experiments on larger animals and from various in vitro experiments. In the current era of mouse mutagenesis and functional genomics, it was our goal to develop a mouse model for pulmonary hypoplasia. We empl...
Array-based comparative genomic hybridization (a-CGH) is a promising tool for clinical genomic st... more Array-based comparative genomic hybridization (a-CGH) is a promising tool for clinical genomic studies. However, pre-analytical sample preparation methods have not been fully evaluated for this purpose. Parallel sections of normal male human skin biopsy samples were collected and immediately immersed in saline, formalin and a molecular fixative for 8, 12 and 24 h. Genomic DNA was isolated from the samples and
Rhinophyma is a slowly progressive, disfiguring disorder of the nose seen almost exclusively in m... more Rhinophyma is a slowly progressive, disfiguring disorder of the nose seen almost exclusively in men. It consists of large nodular masses of hypertrophic and hyperemic connective tissue and sebaceous glands. We present an 89-year-old white man with an unusual cystic variant of rhinophyma. While rhinophyma has 2 different presentations, our case contains not only both spectrums of histologic findings but also multiple cysts. These cysts were present on gross pathologic and microscopic examination and contained both squamous and mucinous epithelium.
Skeletal (striated) muscle is one of the four basic tissue types, together with the epithelium, c... more Skeletal (striated) muscle is one of the four basic tissue types, together with the epithelium, connective and nervous tissues. Lungs, on the other hand, develop from the foregut and among various cell types contain smooth, but not skeletal muscle. Therefore, during earlier stages of development, it is unlikely that skeletal muscle and lung depend on each other. However, during the later stages of development, respiratory muscle, primarily the diaphragm and the intercostal muscles, execute so called fetal breathing-like movements (FBMs), that are essential for lung growth and cell differentiation. In fact, the absence of FBMs results in pulmonary hypoplasia, the most common cause of death in the first week of human neonatal life. Most knowledge on this topic arises from in vivo experiments on larger animals and from various in vitro experiments. In the current era of mouse mutagenesis and functional genomics, it was our goal to develop a mouse model for pulmonary hypoplasia. We empl...
Array-based comparative genomic hybridization (a-CGH) is a promising tool for clinical genomic st... more Array-based comparative genomic hybridization (a-CGH) is a promising tool for clinical genomic studies. However, pre-analytical sample preparation methods have not been fully evaluated for this purpose. Parallel sections of normal male human skin biopsy samples were collected and immediately immersed in saline, formalin and a molecular fixative for 8, 12 and 24 h. Genomic DNA was isolated from the samples and
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Papers by Dijana Gugic Bokun