Iranian Journal of Pharmaceutical Research Ijpr, 2012
The objective of the present investigation was to develop and evaluate a contraceptive vagino-adh... more The objective of the present investigation was to develop and evaluate a contraceptive vagino-adhesive propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including guar gum (1-4% w/w), sodium alginate (4-7% w/w), xanthan gum (2-5% w/w ), HPMC 4000 (3-5% w/w), Na CMC (4-7% w/w), carbomer 934 and carbomer 940 both in the range of 0.5-2.0% w/w, were dispersed in an aqueous-based solution containing the drug (1.6% w/w). The mucoadhesive properties of the gels were assessed on sheep vaginal mucosa (as model mucosa) in pH 4.5 citrate-phosphate buffer at 37°C. Formulations containing charged functional groups in their polymeric structure, showed higher mucoadhesive strengths in comparison to those composed of neutral polymers. In-vitro drug release profiles of the gels were determined in pH 4.5 citrate-phosphate buffer. Results indicated that, only formulation F13 (containing sodium alginate 6.5% w/w), could release its drug over 12 h, with a burst release at the initial phase followed by a sustained release pattern. This formulation, which showed a good mucoadhesive strength (386.97 ± 9.31 mN), was considered as the final formulation and underwent complementary tests including determination of drug content and duration of mucoadhesion. Its drug content was found to be 101.05 ± 0.106% (n = 3) and it attached to the model mucosa for more than 10 h. In conclusion, formulation F13 was considered as the most desirable formulation as it exhibited appropriate mucoadhesive properties while having the potential of providing an immediate contraceptive effect, followed by a prolonged drug release which is assumed to render longer contraceptive efficacy.
This research was done in order to stu dy the effect of different packaging films on the physioch... more This research was done in order to stu dy the effect of different packaging films on the physiochemical properties of three Iranian date varieties (Kabkab. Piarome and Sayer) during storage. These dates were packed at coatings such as polyethylene, polypropylene and cellophane. These dates were stored for six month at three different temperatures (25, 5 and -18 degrees centigrade) and
In this work attempt is made to study the effects of the level of the addition of two dopant syst... more In this work attempt is made to study the effects of the level of the addition of two dopant systems, that is, Nb2O5/Co2O3 and Ba(Nb2/3Co1/3)O3 on the structure, microstructure, and dielectric properties of BaTiO3(BT) prepared by ceramic route. For the BT samples doped with 2 and 3 at % Nb2O5/Co2O3 a broad maxima for er–T variations was observed. Higher levels
Iranian journal of pharmaceutical research : IJPR, 2012
The objective of the present investigation was to develop and evaluate a contraceptive vagino-adh... more The objective of the present investigation was to develop and evaluate a contraceptive vagino-adhesive propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including guar gum (1-4% w/w), sodium alginate (4-7% w/w), xanthan gum (2-5% w/w ), HPMC 4000 (3-5% w/w), Na CMC (4-7% w/w), carbomer 934 and carbomer 940 both in the range of 0.5-2.0% w/w, were dispersed in an aqueous-based solution containing the drug (1.6% w/w). The mucoadhesive properties of the gels were assessed on sheep vaginal mucosa (as model mucosa) in pH 4.5 citrate-phosphate buffer at 37°C. Formulations containing charged functional groups in their polymeric structure, showed higher mucoadhesive strengths in comparison to those composed of neutral polymers. In-vitro drug release profiles of the gels were determined in pH 4.5 citrate-phosphate buffer. Results indicated that, only formulation F13 (containing sodium alginate 6.5% w/w), could release its drug over 12 h, with a burst release at the...
Iranian journal of pharmaceutical research : IJPR, 2015
Diclofenac sodium as ophthalmic dosage form is used for the treatment of the pain, swelling and r... more Diclofenac sodium as ophthalmic dosage form is used for the treatment of the pain, swelling and redness of patients' eyes recovering from cataract surgery; however, it faces the bioavailability limitation of eye drops due to effective protective mechanisms and corneal barrier functions in the eyes. Therefore, this investigation was aimed to develop ocular film formulations to achieve controlled drug release. Drug films were prepared using polymers, namely hydroxypropyl methylcellulose (HPMC) and polyvinyl pyrrolidone (PVP), Eudragit RL PO, and Eudragit RS PO by solvent casting method considering parameters such as drug: polymer ratio, different polymer combinations as well as plasticizer effect. Ocular films were evaluated for various physicochemical parameters such as physical characters, film thickness, uniformity of weight, drug content, swelling index, mucoadhesion time and in-vitro release study. Ocular films complied with all physicochemical parameters underwent in-vitro r...
This study was performed to achieve sustained-release Ibuprofen matrix tablets with a zero-order ... more This study was performed to achieve sustained-release Ibuprofen matrix tablets with a zero-order release kinetic while most of the previous formulations have shown Higuchi release kinetic. Considering the results from previous studies, ethyl cellulose, Carbopol 934P, Carbopol 974P, and Pemulen TR-1 were used at different amounts for preparation of the tablets by direct compression. The release profiles were studied in a two-stage release test using non-linear regression analysis. Carbopols 934P and 974P could not sustain the release adequately while Pemulen TR-1 had too strong sustaining effect. Therefore, combination formulations were considered and studied. The release profiles of ethyl cellulose formulation and the combination formulation consisting Carbopol 934P and Pemulen TR-1 best fitted in Higuchi model, although the zero-order model was not completely rejected. However, the kinetic model of release from the combination formulation consisting Carbopol 974P and Pemulen TR-1 c...
This study details the process of coating theophylline with ethylcellulose using the coacervation... more This study details the process of coating theophylline with ethylcellulose using the coacervation technique of microencapsulation. Microencapsulation of theophylline not only renders it sustained-release, but also decreases its gastric irritation and masks the bitter taste (Lin and Yang 1987). The non-solvent addition method was chosen through a literature survey to ascertain various phases of the coacervate (Robinson 1989, Nixon and Wong 1990). A three-phase diagram was used to determine the optimum quantity of each component required. Steps were then carried out to optimize the production. Drug release rates of the prepared microcapsules were determined over 12-h cycles using the U.S.P. dissolution apparatus and the results obtained were compared with those of Knoll's (Germany) sustained-release theophylline capsules. Significant control over the rate of drug released from the developed dosage form was achieved during the experiment time (12 h). It is concluded that the method employed in this study could be effectively used in the preparation of sustained-release theophylline microcapsules capable of releasing their drug content for an extended period of time. Kinetic studies suggested that both the prepared microcapsules and Knoll's product followed Higuchi's model for drug release. Particle size and release data analysis from five consecutive batches prepared in the laboratory indicated suitable reproducibility of the coacervation process.
A sustained-release tablet formulation should ideally have a proper release profile insensitive t... more A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. In this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose ( ...
... Pump Spray Formulations Nooshin Mehravaran, Hamidreza Moghimi and Seyed AlirezaMortazavi* Dep... more ... Pump Spray Formulations Nooshin Mehravaran, Hamidreza Moghimi and Seyed AlirezaMortazavi* Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Beheshti University (MC), Tehran, Iran. Abstract ...
... of AZG Containing Silicone-Based Gels Seyed Alireza Mortazavi* and Hosseinali Tabandeh Depart... more ... of AZG Containing Silicone-Based Gels Seyed Alireza Mortazavi* and Hosseinali Tabandeh Department of Pharmaceutics, School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Iran. ...
Iranian Journal of Pharmaceutical Research Ijpr, 2012
The objective of the present investigation was to develop and evaluate a contraceptive vagino-adh... more The objective of the present investigation was to develop and evaluate a contraceptive vagino-adhesive propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including guar gum (1-4% w/w), sodium alginate (4-7% w/w), xanthan gum (2-5% w/w ), HPMC 4000 (3-5% w/w), Na CMC (4-7% w/w), carbomer 934 and carbomer 940 both in the range of 0.5-2.0% w/w, were dispersed in an aqueous-based solution containing the drug (1.6% w/w). The mucoadhesive properties of the gels were assessed on sheep vaginal mucosa (as model mucosa) in pH 4.5 citrate-phosphate buffer at 37°C. Formulations containing charged functional groups in their polymeric structure, showed higher mucoadhesive strengths in comparison to those composed of neutral polymers. In-vitro drug release profiles of the gels were determined in pH 4.5 citrate-phosphate buffer. Results indicated that, only formulation F13 (containing sodium alginate 6.5% w/w), could release its drug over 12 h, with a burst release at the initial phase followed by a sustained release pattern. This formulation, which showed a good mucoadhesive strength (386.97 ± 9.31 mN), was considered as the final formulation and underwent complementary tests including determination of drug content and duration of mucoadhesion. Its drug content was found to be 101.05 ± 0.106% (n = 3) and it attached to the model mucosa for more than 10 h. In conclusion, formulation F13 was considered as the most desirable formulation as it exhibited appropriate mucoadhesive properties while having the potential of providing an immediate contraceptive effect, followed by a prolonged drug release which is assumed to render longer contraceptive efficacy.
This research was done in order to stu dy the effect of different packaging films on the physioch... more This research was done in order to stu dy the effect of different packaging films on the physiochemical properties of three Iranian date varieties (Kabkab. Piarome and Sayer) during storage. These dates were packed at coatings such as polyethylene, polypropylene and cellophane. These dates were stored for six month at three different temperatures (25, 5 and -18 degrees centigrade) and
In this work attempt is made to study the effects of the level of the addition of two dopant syst... more In this work attempt is made to study the effects of the level of the addition of two dopant systems, that is, Nb2O5/Co2O3 and Ba(Nb2/3Co1/3)O3 on the structure, microstructure, and dielectric properties of BaTiO3(BT) prepared by ceramic route. For the BT samples doped with 2 and 3 at % Nb2O5/Co2O3 a broad maxima for er–T variations was observed. Higher levels
Iranian journal of pharmaceutical research : IJPR, 2012
The objective of the present investigation was to develop and evaluate a contraceptive vagino-adh... more The objective of the present investigation was to develop and evaluate a contraceptive vagino-adhesive propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including guar gum (1-4% w/w), sodium alginate (4-7% w/w), xanthan gum (2-5% w/w ), HPMC 4000 (3-5% w/w), Na CMC (4-7% w/w), carbomer 934 and carbomer 940 both in the range of 0.5-2.0% w/w, were dispersed in an aqueous-based solution containing the drug (1.6% w/w). The mucoadhesive properties of the gels were assessed on sheep vaginal mucosa (as model mucosa) in pH 4.5 citrate-phosphate buffer at 37°C. Formulations containing charged functional groups in their polymeric structure, showed higher mucoadhesive strengths in comparison to those composed of neutral polymers. In-vitro drug release profiles of the gels were determined in pH 4.5 citrate-phosphate buffer. Results indicated that, only formulation F13 (containing sodium alginate 6.5% w/w), could release its drug over 12 h, with a burst release at the...
Iranian journal of pharmaceutical research : IJPR, 2015
Diclofenac sodium as ophthalmic dosage form is used for the treatment of the pain, swelling and r... more Diclofenac sodium as ophthalmic dosage form is used for the treatment of the pain, swelling and redness of patients' eyes recovering from cataract surgery; however, it faces the bioavailability limitation of eye drops due to effective protective mechanisms and corneal barrier functions in the eyes. Therefore, this investigation was aimed to develop ocular film formulations to achieve controlled drug release. Drug films were prepared using polymers, namely hydroxypropyl methylcellulose (HPMC) and polyvinyl pyrrolidone (PVP), Eudragit RL PO, and Eudragit RS PO by solvent casting method considering parameters such as drug: polymer ratio, different polymer combinations as well as plasticizer effect. Ocular films were evaluated for various physicochemical parameters such as physical characters, film thickness, uniformity of weight, drug content, swelling index, mucoadhesion time and in-vitro release study. Ocular films complied with all physicochemical parameters underwent in-vitro r...
This study was performed to achieve sustained-release Ibuprofen matrix tablets with a zero-order ... more This study was performed to achieve sustained-release Ibuprofen matrix tablets with a zero-order release kinetic while most of the previous formulations have shown Higuchi release kinetic. Considering the results from previous studies, ethyl cellulose, Carbopol 934P, Carbopol 974P, and Pemulen TR-1 were used at different amounts for preparation of the tablets by direct compression. The release profiles were studied in a two-stage release test using non-linear regression analysis. Carbopols 934P and 974P could not sustain the release adequately while Pemulen TR-1 had too strong sustaining effect. Therefore, combination formulations were considered and studied. The release profiles of ethyl cellulose formulation and the combination formulation consisting Carbopol 934P and Pemulen TR-1 best fitted in Higuchi model, although the zero-order model was not completely rejected. However, the kinetic model of release from the combination formulation consisting Carbopol 974P and Pemulen TR-1 c...
This study details the process of coating theophylline with ethylcellulose using the coacervation... more This study details the process of coating theophylline with ethylcellulose using the coacervation technique of microencapsulation. Microencapsulation of theophylline not only renders it sustained-release, but also decreases its gastric irritation and masks the bitter taste (Lin and Yang 1987). The non-solvent addition method was chosen through a literature survey to ascertain various phases of the coacervate (Robinson 1989, Nixon and Wong 1990). A three-phase diagram was used to determine the optimum quantity of each component required. Steps were then carried out to optimize the production. Drug release rates of the prepared microcapsules were determined over 12-h cycles using the U.S.P. dissolution apparatus and the results obtained were compared with those of Knoll's (Germany) sustained-release theophylline capsules. Significant control over the rate of drug released from the developed dosage form was achieved during the experiment time (12 h). It is concluded that the method employed in this study could be effectively used in the preparation of sustained-release theophylline microcapsules capable of releasing their drug content for an extended period of time. Kinetic studies suggested that both the prepared microcapsules and Knoll's product followed Higuchi's model for drug release. Particle size and release data analysis from five consecutive batches prepared in the laboratory indicated suitable reproducibility of the coacervation process.
A sustained-release tablet formulation should ideally have a proper release profile insensitive t... more A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. In this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose ( ...
... Pump Spray Formulations Nooshin Mehravaran, Hamidreza Moghimi and Seyed AlirezaMortazavi* Dep... more ... Pump Spray Formulations Nooshin Mehravaran, Hamidreza Moghimi and Seyed AlirezaMortazavi* Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Beheshti University (MC), Tehran, Iran. Abstract ...
... of AZG Containing Silicone-Based Gels Seyed Alireza Mortazavi* and Hosseinali Tabandeh Depart... more ... of AZG Containing Silicone-Based Gels Seyed Alireza Mortazavi* and Hosseinali Tabandeh Department of Pharmaceutics, School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Iran. ...
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