Papers by Elena Fedorova
Scientifica, 2016
The paper focuses on the assessment of the spectrum of biological activities (antineoplastic, ant... more The paper focuses on the assessment of the spectrum of biological activities (antineoplastic, anti-inflammatory, antifungal, and antibacterial) with PASS (Prediction of Activity Spectra for Substances) for the major components of three macrophytes widespread in the Holarctic species of freshwater, emergent macrophyte with floating leaves,Nuphar lutea(L.) Sm., and two species of submergent macrophyte groups,Ceratophyllum demersumL. andPotamogeton obtusifolius(Mert. et Koch), for the discovery of their ecological and pharmacological potential. The predicted probability of anti-inflammatory or antineoplastic activities above 0.8 was observed for twenty compounds. The same compounds were also characterized by high probability of antifungal and antibacterial activity. Six metabolites, namely, hexanal, pentadecanal, tetradecanoic acid, dibutyl phthalate, hexadecanoic acid, and manool, were a part of the major components of all three studied plants, indicating their high ecological signifi...
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Six amidrazone derivatives were synthesized. Their structure was determined using modern analytic... more Six amidrazone derivatives were synthesized. Their structure was determined using modern analytical methods (TLC, mass spectrometry, elemental analysis, 1H NMR spectrometry and infrared spectroscopy). As starting compounds for the preparation of substituted amidrazones hydrazonoyl chlorides commercially available compounds were used. Computer program PASS (Prediction of Activity Spectra for Substances) has been applied for prediction of biological activity spectra of synthetic substances with the aim to discover their pharmacological potential. Computer-aided prediction of interaction amidrazone derivatives with protein targets was carried out with specialized version of the computer program PASS - PASS Targets. Open- source program AutoDock Vina was used for docking of amidrazones to crystal structures of targets: Candida albicans glucan 1,3-β-glucosidase (PDB code 2PB1), Candida albicans ATP-dependent molecular chaperone HSP82 (PDB code 2IWX), Staphylococcus aureus dehydrosqualene synthase (PDB code 3ACX), Bacillus subtillis 4'-phosphopantetheinyl transferase sfp (PDB code 1QR0) and Escherichia coli cystathioninebeta-lyase metC (PDB code 1CL2). Antimicrobial activity was studied by two-fold serial dilutions of the sample in the meat-broth and Sabouraud medium. As a test cultures microorganisms were used: Staphylococcus aureus АТСС 6538-Р, Bacillus cereus ATCC 6633, Escherichia coli АТСС 25922, Candida albicans NCTC 885-653, Aspirgillus niger ATCC 9642. The resulting compounds showed a potation antimicrobial activity.
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Conference Presentations by Elena Fedorova
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Review by Elena Fedorova
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Papers by Elena Fedorova
Conference Presentations by Elena Fedorova
Review by Elena Fedorova
Personal web page by Elena Fedorova