Saheed Adekola
Brief Profile of Saheed Adekola
Saheed Adekola born December 8, 1980s. Saheed Adekola is a highly accomplished biomedical scientist, dedicated researcher, and esteemed lecturer currently positioned at the Department of Medical Laboratory Science within the Faculty of Nursing and Allied Health Sciences at the University of Abuja. Saheed earned his Bachelor's degree in Medical Laboratory Science from Ladoke Akintola University of Technology (LAUTECH) in 2009, showcasing his commitment to excellence in the field. His insatiable quest for knowledge led him to further his education, obtaining a Master's degree in Chemical Pathology and Immunology from the prestigious University of Ibadan in 2014. Currently, he is pursuing a Ph.D. in Medical Laboratory Science with a focus on Chemical Pathology, displaying a continuous dedication to advancing his expertise. Saheed is a registered Medical Laboratory Scientist with the Medical Laboratory Science Council of Nigeria, demonstrating his adherence to professional standards in the field. Additionally, his recognition extends globally, being a certified Biomedical Scientist with the Health Care Professional Council in the United Kingdom and a member of the American Society of Clinical Pathology. With over five years of teaching experience in both public and private universities, Saheed has become a respected figure in academia. His passion for shaping the next generation of medical laboratory professionals is evident in his engaging and insightful teaching methodologies. As a prolific researcher, Saheed has accumulated a wealth of experience, contributing significantly to the scientific community. His research endeavors span both clinical and research laboratories, within and outside Nigeria. With a track record of over ten years as a certified Medical Laboratory Scientist, Saheed has garnered a profound understanding of the intricacies of laboratory practice. Saheed's scholarly impact is reflected in his extensive list of publications, showcasing his commitment to advancing knowledge in the field. His contributions to more than 10 publications underscore his role as a thought leader in medical laboratory science. With an impressive blend of academic, research, and professional accomplishments, Saheed Adekola stands as a prominent figure in the field of biomedical science, contributing significantly to the advancement of medical laboratory science education and research.
Supervisors: Prof. Oparinde, , Prof Olaniyan, and Dr. Charles-Davies
Phone: 2348037797127
Address: C/O Department of Chemical Pathology, Medical Laboratory Science Program,
Faculty of Nursing & Allied Health Sciences
University of Abuja Teaching Hospital,
Saheed Adekola born December 8, 1980s. Saheed Adekola is a highly accomplished biomedical scientist, dedicated researcher, and esteemed lecturer currently positioned at the Department of Medical Laboratory Science within the Faculty of Nursing and Allied Health Sciences at the University of Abuja. Saheed earned his Bachelor's degree in Medical Laboratory Science from Ladoke Akintola University of Technology (LAUTECH) in 2009, showcasing his commitment to excellence in the field. His insatiable quest for knowledge led him to further his education, obtaining a Master's degree in Chemical Pathology and Immunology from the prestigious University of Ibadan in 2014. Currently, he is pursuing a Ph.D. in Medical Laboratory Science with a focus on Chemical Pathology, displaying a continuous dedication to advancing his expertise. Saheed is a registered Medical Laboratory Scientist with the Medical Laboratory Science Council of Nigeria, demonstrating his adherence to professional standards in the field. Additionally, his recognition extends globally, being a certified Biomedical Scientist with the Health Care Professional Council in the United Kingdom and a member of the American Society of Clinical Pathology. With over five years of teaching experience in both public and private universities, Saheed has become a respected figure in academia. His passion for shaping the next generation of medical laboratory professionals is evident in his engaging and insightful teaching methodologies. As a prolific researcher, Saheed has accumulated a wealth of experience, contributing significantly to the scientific community. His research endeavors span both clinical and research laboratories, within and outside Nigeria. With a track record of over ten years as a certified Medical Laboratory Scientist, Saheed has garnered a profound understanding of the intricacies of laboratory practice. Saheed's scholarly impact is reflected in his extensive list of publications, showcasing his commitment to advancing knowledge in the field. His contributions to more than 10 publications underscore his role as a thought leader in medical laboratory science. With an impressive blend of academic, research, and professional accomplishments, Saheed Adekola stands as a prominent figure in the field of biomedical science, contributing significantly to the advancement of medical laboratory science education and research.
Supervisors: Prof. Oparinde, , Prof Olaniyan, and Dr. Charles-Davies
Phone: 2348037797127
Address: C/O Department of Chemical Pathology, Medical Laboratory Science Program,
Faculty of Nursing & Allied Health Sciences
University of Abuja Teaching Hospital,
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selected and pre-test questionnaire administered. 18% had been transfused before while 82% had not been transfused. 80% of the respondents are ready to accept blood transfusion while 20% will refuse blood transfusion. 86% can encourage their relatives to accept blood transfusion while 14% will not encourage their relatives. Out of 500 participants, 190(41.3%) have adequate understanding of blood transfusion. 50% of the
respondents in this study would refuse blood transfusion due to fear of infections. In conclusion, the attitude of the respondents in this study is generally satisfactory. However, knowledge regarding blood transfusion is insufficient, and the low readiness for blood transfusion is a cause for concern. Therefore, educational programs on blood transfusion should be expanded through various media such as the social media (Facebook, Twitter etc). This program should be used to spread the idea that blood transfusion does not pose significant health risks. The public should also be informed that all measures are implemented by Medical Laboratory Professionals working in the blood bank to ensure the donated blood is safe for recipients.
Eighty-three males participated in this prospective cross sectional study after informed consent.
Forty-three were male auto-mechanics, occupationally exposed to mixed chemicals in the mechanic community, Bodija, Ibadan (cases). Their mean (SEM) age and body mass index (BMI) were 42.5 (1.7) years and 23.8 (0.5) Kg/m2 respectively. They were age and BMI matched with 40 unexposed, apparently healthy males from the University College Hospital and environs (controls). Demography, social habits, anthropometry and gonadal status were obtained by standard methods. Serum obtained from blood (10 ml) collected from the participants was used for biochemical analyses. Testosterone levels were determined by enzyme immunoassay method (Immunometrics
UK Ltd). Levels of total antioxidant capacity, total plasma peroxide (TPP), malondialdehyde (MDA), hydrogen peroxide (H2O2), glutathione peroxidase (GPX), superoxide dismutase (SOD), glutathione-S-transferase (GST), and reduced glutathione (GSH) were determined using spectrophotometric methods while oxidative stress index (OSI) was calculated. P<0.05 was
regarded as significant.
TPP, MDA, OSI, H2O2 and GST `levels were significantly higher (P<0.001) in eugonadal cases compared with controls. All these biomarkers levels were similar in hypogonadal compared with
eugonadal cases. (P>0.05) Testosterone related negatively with SOD in the controls only but positively with MDA and negatively with GST in cases only (P<0.05).
Occupationally exposed auto mechanics appear to have oxidative stress and may benefit improvement in antioxidant status. Testosterone may contribute to and enhance total antioxidant status, which may be important in gonadal function.
Forty-three males, auto mechanics aged 18-60 years occupationally exposed to mixed chemicals (MCG) at their work place in Bodija mechanic village with mean±SEM duration of 21.2±1.9 years were age matched with 40 unexposed males (controls) from the University College Hospital, Ibadan and environs. Demography, anthropometry, blood pressure and sexual history were obtained by standard methods. Blood (10 ml) was obtained from each participant for estimation of reproductive hormones by enzyme linked immunosorbent assay while total antioxidant capacity (TAC) was determined spectrophotometrically. Testosterone/oestradiol ratio (TE ratio) was calculated. The MCG were classified based on their reproductive hormone levels into 4 subgroupsas eugonadic, hypogonadotrophic hypogonadism, sub-optimal hypogonadism and compensated hypogonadism. P<0.05 was regarded as significant. There were significantly raised oestradiol levels, diastolic blood pressure, waist circumference and waist to hip ratio and significantly lower TAC and TE ratio in the MCG than the controls (P<0.01).
Exposed hypogonadic males exhibited significantly lower LH, FSH, testosterone, prolactin, TAC
levels and TE ratio than exposed eugonadic males (P<0.05).
Hypogonadism in the males exposed to mixed chemicals may be associated with reduced TE ratio
resulting from increased adipose mass as well as oxidative stress associated with the mixed
chemical exposure.
Africa has great intensity of chemical exposure and high level of infertility. Functional disorders of the male germ cell and endocrinopathies have been attributed to exposure to mixed chemicals. Data on the mixed chemical exposure on reproductive hormones are sparse in Nigeria. This study was designed to evaluate male reproductive hormones and determinants of occupational exposure to mixed chemicals in a mechanic village in Ibadan. Forty-three males, auto mechanics aged 18-60 years occupationally exposed to mixed chemicals
(MCG) at their work place in Bodija mechanic village with mean±SEM duration of 21.2±1.9 years were age matched with 40 unexposed males (controls) from the University College Hospital, Ibadan and environs. Demography, anthropometry, blood pressure and sexual history were obtained by standard methods. Blood (10 ml) was obtained from each participant for estimation of reproductive hormones by enzyme linked immunosorbent assay while total antioxidant capacity (TAC) was determined spectrophotometrically. Testosterone/oestradiol ratio (TE ratio) was calculated. The MCG were classified based on their reproductive hormone levels into 4 subgroups as eugonadic, hypogonadotrophic hypogonadism, sub-optimal hypogonadism and compensated
hypogonadism. P<0.05 was regarded as significant.
There were significantly raised oestradiol levels, diastolic blood pressure, waist circumference and
waist to hip ratio and significantly lower TAC and TE ratio in the MCG than the controls (P<0.01). Exposed hypogonadic males exhibited significantly lower LH, FSH, testosterone, prolactin, TAC levels and TE ratio than exposed eugonadic males (P<0.05).
Hypogonadism in the males exposed to mixed chemicals may be associated with reduced TE ratio resulting from increased adipose mass as well as oxidative stress associated with the mixed chemical exposure.
Hepatitis B and C viruses’ infections are one of the world’s most common infectious diseases infecting two billion people including an estimated 400 million with the chronic infection cases. This present study was performed to determine the prevalence of hepatitis B and C viruses among intending blood donors at Mother and Child Hospital, Akure, Ondo State, Nigeria. 2920 intending blood donors were screened between the periods of March 2010 to April 2011 using Enzyme Linked Immunosorbent Assay (ELISA) tests. The prevalence of Hepatitis infections among the intending blood donors was 290(9.9%). HBsAg and anti-HCV were reactive in 7.4% and 2.1% of the study population respectively while co-infection was recorded in 0.4% of the intending donors. In conclusion, this study confirmed the presence of hepatitis B surface antigen and HCV among intending blood donors and that these infections can be transmitted through blood donors in Akure, Nigeria.
Keyword- Hepatitis B, hepatitis C, Blood donors, Nigeria, Akure
Methods: This present study was carried out to establish the rifampicin resistant profiles among the patients attending chest clinic, state specialist hospital, Akure. We enrolled clinical samples submitted between January 2013 and December 2013 for this study. The sputum samples were analyzed using GeneXpert.
Results: Of the 135 sputum processed by GeneXpert, 48 (35.6%) contained Mycobacteria tuberculosis (MTB) and 9 (18.8%) were rifampicin resistant Mycobacteria tuberculosis. Patients within the age group of 24-32 years showed the highest resistant to RIF 6 (12.5%).
Conclusion: This study has helped to establish that there is presence of rifampicin resistant Mycobacterium tuberculosis in Akure, Ondo state, Nigeria and most of them were observed among patients who default treatment. This is considered as a threat to TB control programme in Akure, Nigeria and it is recommended that strategies should be put in place in order to ensure patients’ compliance and monitoring of patients’ response to TB treatment.
Keywords: Rifampicin resistant, Mycobacterium tuberculosis, GeneXpert, Akure
selected and pre-test questionnaire administered. 18% had been transfused before while 82% had not been transfused. 80% of the respondents are ready to accept blood transfusion while 20% will refuse blood transfusion. 86% can encourage their relatives to accept blood transfusion while 14% will not encourage their relatives. Out of 500 participants, 190(41.3%) have adequate understanding of blood transfusion. 50% of the
respondents in this study would refuse blood transfusion due to fear of infections. In conclusion, the attitude of the respondents in this study is generally satisfactory. However, knowledge regarding blood transfusion is insufficient, and the low readiness for blood transfusion is a cause for concern. Therefore, educational programs on blood transfusion should be expanded through various media such as the social media (Facebook, Twitter etc). This program should be used to spread the idea that blood transfusion does not pose significant health risks. The public should also be informed that all measures are implemented by Medical Laboratory Professionals working in the blood bank to ensure the donated blood is safe for recipients.
Eighty-three males participated in this prospective cross sectional study after informed consent.
Forty-three were male auto-mechanics, occupationally exposed to mixed chemicals in the mechanic community, Bodija, Ibadan (cases). Their mean (SEM) age and body mass index (BMI) were 42.5 (1.7) years and 23.8 (0.5) Kg/m2 respectively. They were age and BMI matched with 40 unexposed, apparently healthy males from the University College Hospital and environs (controls). Demography, social habits, anthropometry and gonadal status were obtained by standard methods. Serum obtained from blood (10 ml) collected from the participants was used for biochemical analyses. Testosterone levels were determined by enzyme immunoassay method (Immunometrics
UK Ltd). Levels of total antioxidant capacity, total plasma peroxide (TPP), malondialdehyde (MDA), hydrogen peroxide (H2O2), glutathione peroxidase (GPX), superoxide dismutase (SOD), glutathione-S-transferase (GST), and reduced glutathione (GSH) were determined using spectrophotometric methods while oxidative stress index (OSI) was calculated. P<0.05 was
regarded as significant.
TPP, MDA, OSI, H2O2 and GST `levels were significantly higher (P<0.001) in eugonadal cases compared with controls. All these biomarkers levels were similar in hypogonadal compared with
eugonadal cases. (P>0.05) Testosterone related negatively with SOD in the controls only but positively with MDA and negatively with GST in cases only (P<0.05).
Occupationally exposed auto mechanics appear to have oxidative stress and may benefit improvement in antioxidant status. Testosterone may contribute to and enhance total antioxidant status, which may be important in gonadal function.
Forty-three males, auto mechanics aged 18-60 years occupationally exposed to mixed chemicals (MCG) at their work place in Bodija mechanic village with mean±SEM duration of 21.2±1.9 years were age matched with 40 unexposed males (controls) from the University College Hospital, Ibadan and environs. Demography, anthropometry, blood pressure and sexual history were obtained by standard methods. Blood (10 ml) was obtained from each participant for estimation of reproductive hormones by enzyme linked immunosorbent assay while total antioxidant capacity (TAC) was determined spectrophotometrically. Testosterone/oestradiol ratio (TE ratio) was calculated. The MCG were classified based on their reproductive hormone levels into 4 subgroupsas eugonadic, hypogonadotrophic hypogonadism, sub-optimal hypogonadism and compensated hypogonadism. P<0.05 was regarded as significant. There were significantly raised oestradiol levels, diastolic blood pressure, waist circumference and waist to hip ratio and significantly lower TAC and TE ratio in the MCG than the controls (P<0.01).
Exposed hypogonadic males exhibited significantly lower LH, FSH, testosterone, prolactin, TAC
levels and TE ratio than exposed eugonadic males (P<0.05).
Hypogonadism in the males exposed to mixed chemicals may be associated with reduced TE ratio
resulting from increased adipose mass as well as oxidative stress associated with the mixed
chemical exposure.
Africa has great intensity of chemical exposure and high level of infertility. Functional disorders of the male germ cell and endocrinopathies have been attributed to exposure to mixed chemicals. Data on the mixed chemical exposure on reproductive hormones are sparse in Nigeria. This study was designed to evaluate male reproductive hormones and determinants of occupational exposure to mixed chemicals in a mechanic village in Ibadan. Forty-three males, auto mechanics aged 18-60 years occupationally exposed to mixed chemicals
(MCG) at their work place in Bodija mechanic village with mean±SEM duration of 21.2±1.9 years were age matched with 40 unexposed males (controls) from the University College Hospital, Ibadan and environs. Demography, anthropometry, blood pressure and sexual history were obtained by standard methods. Blood (10 ml) was obtained from each participant for estimation of reproductive hormones by enzyme linked immunosorbent assay while total antioxidant capacity (TAC) was determined spectrophotometrically. Testosterone/oestradiol ratio (TE ratio) was calculated. The MCG were classified based on their reproductive hormone levels into 4 subgroups as eugonadic, hypogonadotrophic hypogonadism, sub-optimal hypogonadism and compensated
hypogonadism. P<0.05 was regarded as significant.
There were significantly raised oestradiol levels, diastolic blood pressure, waist circumference and
waist to hip ratio and significantly lower TAC and TE ratio in the MCG than the controls (P<0.01). Exposed hypogonadic males exhibited significantly lower LH, FSH, testosterone, prolactin, TAC levels and TE ratio than exposed eugonadic males (P<0.05).
Hypogonadism in the males exposed to mixed chemicals may be associated with reduced TE ratio resulting from increased adipose mass as well as oxidative stress associated with the mixed chemical exposure.
Hepatitis B and C viruses’ infections are one of the world’s most common infectious diseases infecting two billion people including an estimated 400 million with the chronic infection cases. This present study was performed to determine the prevalence of hepatitis B and C viruses among intending blood donors at Mother and Child Hospital, Akure, Ondo State, Nigeria. 2920 intending blood donors were screened between the periods of March 2010 to April 2011 using Enzyme Linked Immunosorbent Assay (ELISA) tests. The prevalence of Hepatitis infections among the intending blood donors was 290(9.9%). HBsAg and anti-HCV were reactive in 7.4% and 2.1% of the study population respectively while co-infection was recorded in 0.4% of the intending donors. In conclusion, this study confirmed the presence of hepatitis B surface antigen and HCV among intending blood donors and that these infections can be transmitted through blood donors in Akure, Nigeria.
Keyword- Hepatitis B, hepatitis C, Blood donors, Nigeria, Akure
Methods: This present study was carried out to establish the rifampicin resistant profiles among the patients attending chest clinic, state specialist hospital, Akure. We enrolled clinical samples submitted between January 2013 and December 2013 for this study. The sputum samples were analyzed using GeneXpert.
Results: Of the 135 sputum processed by GeneXpert, 48 (35.6%) contained Mycobacteria tuberculosis (MTB) and 9 (18.8%) were rifampicin resistant Mycobacteria tuberculosis. Patients within the age group of 24-32 years showed the highest resistant to RIF 6 (12.5%).
Conclusion: This study has helped to establish that there is presence of rifampicin resistant Mycobacterium tuberculosis in Akure, Ondo state, Nigeria and most of them were observed among patients who default treatment. This is considered as a threat to TB control programme in Akure, Nigeria and it is recommended that strategies should be put in place in order to ensure patients’ compliance and monitoring of patients’ response to TB treatment.
Keywords: Rifampicin resistant, Mycobacterium tuberculosis, GeneXpert, Akure