The multidomain protein kinase BubR1 is a central component of the mitotic spindle assembly check... more The multidomain protein kinase BubR1 is a central component of the mitotic spindle assembly checkpoint (SAC), an essential self-monitoring system of the eukaryotic cell cycle that ensures the high fidelity of chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bi-oriented on the mitotic spindle. We discuss the roles of BubR1 in the SAC and the implications of BubR1-mediated interactions that protect against aneuploidy. We also describe the emerging roles of BubR1 in cellular processes that extend beyond the SAC, discuss how mice models have revealed unanticipated functions for BubR1 in the regulation of normal aging, and the potential role of BubR1 as therapeutic target for the development of innovative anticancer therapies.
The spindle assembly checkpoint (SAC) is an essential control system of the eukaryotic cell cycle... more The spindle assembly checkpoint (SAC) is an essential control system of the eukaryotic cell cycle that ensures genome stability. The essence of this evolutionarily conserved mechanism is to delay mitosis progression until proper chromosome bi-orientation and attachment is achieved. Mutations in the genes encoding for diverse checkpoint proteins lead to the impairment of the mitotic checkpoint mechanism, thus resulting in the premature separation of sister chromatids and aneuploidy, a condition that is associated with various classes of cancer. The understanding of the organisation, structure and function of SAC components is essential for the molecular understanding of the process and to identify and evaluate new targets for cancer drug therapy.
The multidomain protein kinase BubR1 is a central component of the mitotic spindle assembly check... more The multidomain protein kinase BubR1 is a central component of the mitotic spindle assembly checkpoint (SAC), an essential self-monitoring system of the eukaryotic cell cycle that ensures the high fidelity of chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bi-oriented on the mitotic spindle. We discuss the roles of BubR1 in the SAC and the implications of BubR1-mediated interactions that protect against aneuploidy. We also describe the emerging roles of BubR1 in cellular processes that extend beyond the SAC, discuss how mice models have revealed unanticipated functions for BubR1 in the regulation of normal aging, and the potential role of BubR1 as therapeutic target for the development of innovative anticancer therapies.
The spindle assembly checkpoint (SAC) is an essential control system of the eukaryotic cell cycle... more The spindle assembly checkpoint (SAC) is an essential control system of the eukaryotic cell cycle that ensures genome stability. The essence of this evolutionarily conserved mechanism is to delay mitosis progression until proper chromosome bi-orientation and attachment is achieved. Mutations in the genes encoding for diverse checkpoint proteins lead to the impairment of the mitotic checkpoint mechanism, thus resulting in the premature separation of sister chromatids and aneuploidy, a condition that is associated with various classes of cancer. The understanding of the organisation, structure and function of SAC components is essential for the molecular understanding of the process and to identify and evaluate new targets for cancer drug therapy.
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Papers by Maria Kapanidou