Krummel et al., 1988 - Google Patents
Transforming growth factor beta (TGF-β) induces fibrosis in a fetal wound modelKrummel et al., 1988
- Document ID
- 2475412010840953513
- Author
- Krummel T
- Michna B
- Thomas B
- Sporn M
- Nelson J
- Salzberg A
- Cohen I
- Diegelmann R
- Publication year
- Publication venue
- Journal of pediatric surgery
External Links
Snippet
The adult cellular response to tissue injury is characterized by acute inflammation followed eventually by fibroblast proliferation and collagen synthesis. Fetal tissue responses to injury differ markedly from those of the adult; an early acute inflammatory response is absent, few …
- 230000001605 fetal 0 title abstract description 48
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Krummel et al. | Transforming growth factor beta (TGF-β) induces fibrosis in a fetal wound model | |
Clark et al. | Fibronectin is produced by blood vessels in response to injury. | |
Colwell et al. | Fetal wound healing | |
Desmoulière et al. | The role of the myofibroblast in wound healing and fibrocontractive diseases | |
Duncan et al. | Connective tissue growth factor mediates transforming growth factor β‐induced collagen synthesis: down‐regulation by cAMP | |
Harrison et al. | The mechanism of skin graft contraction: an update on current research and potential future therapies | |
Clark et al. | Fibronectin beneath reepithelializing epidermis in vivo: sources and significance. | |
CA2105652C (en) | Reducing wound scarring with antibodies to growth factors | |
JP4065846B2 (en) | Creation of tissue engineered female reproductive organs | |
JP3040815B2 (en) | Proliferative effect of leukemia inhibitory factor on associated cells | |
Geer et al. | Fibrin promotes migration in a three-dimensional in vitro model of wound regeneration | |
Depalma et al. | Characterization and quantitation of wound matrix in the fetal rabbit | |
Olutoye et al. | Lower cytokine release by fetal porcine platelets: a possible explanation for reduced inflammation after fetal wounding | |
Siebert et al. | Fetal wound healing: a biochemical study of scarless healing | |
EP3479831B1 (en) | Composition comprising thrombin-treated stem cell-derived exosome for use in treating skin wound | |
US5720981A (en) | Epidermal cell extracts and method to enhance wound healing and regenerate epidermis | |
US20070154529A1 (en) | Uses of dna binding proteins | |
Lemaire et al. | Alveolar macrophage stimulation of lung fibroblast growth in asbestos-induced pulmonary fibrosis. | |
US6503504B1 (en) | Delivery of bioactive compounds to an organism | |
JP2001506268A (en) | Use of peptides to improve uptake of skin grafts | |
JP2000508922A (en) | Skin regeneration using mesenchymal stem cells | |
WO1991010424A1 (en) | Method of inhibiting angiogenesis of tumors | |
Sawai et al. | Hyaluronic acid of wound fluid in adult and fetal rabbits | |
Kurita et al. | Immunohistochemical localization of basic fibroblast growth factor in wound healing sites of mouse skin | |
EP0437281B1 (en) | Composition comprising acidic fibroblast growth factor (aFGF) |