CYP3A5

citocromo P450, família 3, subfamília A, polipeptídeo 5
Identificadores
Símbolos	CYP3A5; CP35; CYPIIIA5; P450PCN3; PCN3
IDs externos	OMIM: 605325 MGI: 88609 HomoloGene: 121493 ChEMBL: 3019 GeneCards: CYP3A5 Gene
Número EC	1.14.14.1
Ontologia do gene
Função molecular	•monooxygenase activity; •iron ion binding; •electron carrier activity; •oxidoreductase activity; •oxygen binding; •heme binding; •aromatase activity;
Componente celular	•endoplasmic reticulum membrane; •intracellular membrane-bounded organelle;
Processo biológico	•xenobiotic metabolic process; •steroid metabolic process; •alkaloid catabolic process; •drug catabolic process; •small molecule metabolic process; •oxidative demethylation;
	Sources: Amigo / QuickGO
Padrões de expressão do ARN
	Mais dados de expressão
Ortólogos
	v; d; e;

Citocromo P450 3A5 é uma proteína que em humanos é codificada pelo gene CYP3A5.

Descrição

Este gene codifica um membro da superfamília citocromo P450, que são enzimas que catalisam as reações envolvidas no metabolismo de muitas drogas e da síntese de colesterol, esteróides e outros lipídeos. A CYP3A5 se localiza no retículo endoplasmático e a sua expressão é induzida por glucocorticóides e por alguns agentes farmacológicos. Ela metaboliza drogas, tais como a nifedipina e a ciclosporina, bem como os esteróides progesterona, testosterona e androstenediona. O gene CYP3A5 é parte de um conjunto de genes do citocromo P450 localizado no cromossomo 7q21.1 e este conjunto inclui um pseudogene, o CYP3A5P1, que é muito semelhante ao CYP3A5. Esta semelhança tem causado alguma dificuldade em determinar se as sequências clonadas representam o gene ou o pseudogene. ^[1]

Referências

↑ «Entrez Gene: CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5»

Artigos científicos

Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). «Molecular genetics of the human cytochrome P450 monooxygenase superfamily.». Xenobiotica. 28 (12): 1129–65. PMID 9890157. doi:10.1080/004982598238868
Lee SJ, Goldstein JA (2006). «Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests.». Pharmacogenomics. 6 (4): 357–71. PMID 16004554. doi:10.1517/14622416.6.4.357
Aoyama T, Yamano S, Waxman DJ,; et al. (1989). «Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.». J. Biol. Chem. 264 (18): 10388–95. PMID 2732228
Schuetz JD, Molowa DT, Guzelian PS (1989). «Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver.». Arch. Biochem. Biophys. 274 (2): 355–65. PMID 2802615. doi:10.1016/0003-9861(89)90449-9
Murray GI, Pritchard S, Melvin WT, Burke MD (1995). «Cytochrome P450 CYP3A5 in the human anterior pituitary gland.». FEBS Lett. 364 (1): 79–82. PMID 7750548. doi:10.1016/0014-5793(95)00367-I
Jounaïdi Y, Guzelian PS, Maurel P, Vilarem MJ (1995). «Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.». Biochem. Biophys. Res. Commun. 205 (3): 1741–7. PMID 7811260. doi:10.1006/bbrc.1994.2870
McKinnon RA, Burgess WM, Hall PM,; et al. (1995). «Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues.». Gut. 36 (2): 259–67. PMC 1382414. PMID 7883227. doi:10.1136/gut.36.2.259
Kolars JC, Lown KS, Schmiedlin-Ren P,; et al. (1995). «CYP3A gene expression in human gut epithelium.». Pharmacogenetics. 4 (5): 247–59. PMID 7894497. doi:10.1097/00008571-199410000-00003
Lown KS, Kolars JC, Thummel KE,; et al. (1995). «Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test.». Drug Metab. Dispos. 22 (6): 947–55. PMID 7895614
Schuetz JD, Beach DL, Guzelian PS (1994). «Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver.». Pharmacogenetics. 4 (1): 11–20. PMID 8004129. doi:10.1097/00008571-199402000-00002
Maruyama K, Sugano S (1994). «Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.». Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8
Schuetz JD, Schuetz EG, Thottassery JV,; et al. (1996). «Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.». Mol. Pharmacol. 49 (1): 63–72. PMID 8569713
Jounaïdi Y, Hyrailles V, Gervot L, Maurel P (1996). «Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?». Biochem. Biophys. Res. Commun. 221 (2): 466–70. PMID 8619878. doi:10.1006/bbrc.1996.0618
Hakkola J, Pasanen M, Hukkanen J,; et al. (1996). «Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta.». Biochem. Pharmacol. 51 (4): 403–11. PMID 8619884. doi:10.1016/0006-2952(95)02184-1
Hakkola J, Raunio H, Purkunen R,; et al. (1996). «Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy.». Biochem. Pharmacol. 52 (2): 379–83. PMID 8694864. doi:10.1016/0006-2952(96)00216-X
Huang Z, Fasco MJ, Figge HL,; et al. (1997). «Expression of cytochromes P450 in human breast tissue and tumors.». Drug Metab. Dispos. 24 (8): 899–905. PMID 8869826
Kivistö KT, Bookjans G, Fromm MF,; et al. (1997). «Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue.». British Journal of Clinical Pharmacology. 42 (3): 387–9. PMC 2042681. PMID 8877031. doi:10.1046/j.1365-2125.1996.42615.x
Janardan SK, Lown KS, Schmiedlin-Ren P,; et al. (1997). «Selective expression of CYP3A5 and not CYP3A4 in human blood.». Pharmacogenetics. 6 (5): 379–85. PMID 8946469. doi:10.1097/00008571-199610000-00001
Anttila S, Hukkanen J, Hakkola J,; et al. (1997). «Expression and localization of CYP3A4 and CYP3A5 in human lung.». Am. J. Respir. Cell Mol. Biol. 16 (3): 242–9. PMID 9070608
Hukkanen J, Hakkola J, Anttila S,; et al. (1997). «Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes.». Mol. Carcinog. 20 (2): 224–30. PMID 9364212. doi:10.1002/(SICI)1098-2744(199710)20:2<224::AID-MC9>3.0.CO;2-M

[1] «Entrez Gene: CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5»

[1]